Nina M. Wolf
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View article: Structure-Based Analysis of Semisynthetic Anti-TB Rufomycin Analogues
Structure-Based Analysis of Semisynthetic Anti-TB Rufomycin Analogues Open
This study employed structural information from cocrystals of rufomycin 4 (1a) and caseinolytic protein C1 (ClpC1)-NTD-wt to guide design and semisynthesis of rufomycin analogues, evaluate their antituberculosis (TB) biological profiles, a…
View article: New Rufomycins from <i>Streptomyces atratus</i> MJM3502 Expand Anti-<i>Mycobacterium tuberculosis</i> Structure–Activity Relationships
New Rufomycins from <i>Streptomyces atratus</i> MJM3502 Expand Anti-<i>Mycobacterium tuberculosis</i> Structure–Activity Relationships Open
Four new rufomycins, compounds 1-4, named rufomycins 56, 57, 58, and 61, respectively, exhibiting new skeletal features, were obtained from Streptomyces atratus strain MJM3502 and were fully characterized. Compounds 1 and 2 possess a 4-imi…
Structural and biochemical characterization of the class II fructose-1,6-bisphosphatase from <i>Francisella tularensis</i> Open
The crystal structure of the class II fructose-1,6-bisphosphatase (FBPaseII) from the important pathogen Francisella tularensis is presented at 2.4 Å resolution. Its structural and functional relationships to the closely related phosphatas…
Structure of the N-terminal domain of ClpC1 in complex with the antituberculosis natural product ecumicin reveals unique binding interactions Open
The biological processes related to protein homeostasis in Mycobacterium tuberculosis , the etiologic agent of tuberculosis, have recently been established as critical pathways for therapeutic intervention. Proteins of particular interest …
Rv0100, a proposed acyl carrier protein in <i>Mycobacterium tuberculosis</i>: expression, purification and crystallization. Corrigendum Open
The true identity of the protein found in the crystals reported by Bondoc et al. [(2019), Acta Cryst. F 75 , 646–651] is given.
CCDC 1957302: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
Antimycobacterial Rufomycin Analogues from <i>Streptomyces atratus</i> Strain MJM3502 Open
This study represents a systematic chemical and biological study of the rufomycin (RUF) class of cyclic heptapeptides, which our anti-TB drug discovery efforts have identified as potentially promising anti-TB agents that newly target the c…
Rv0100, a proposed acyl carrier protein in <i>Mycobacterium tuberculosis</i>: expression, purification and crystallization Open
Acyl carrier proteins (ACPs) are important components in fatty-acid biosynthesis in prokaryotes. Rv0100 is predicted to be an essential ACP in Mycobacterium tuberculosis , the pathogen that is the causative agent of tuberculosis, and there…
Structures of ClpC1-NTD with potent anti-TB cyclic peptides Rufomycin and Ecumicin: implications for the mechanism of action and design of therapeutic agents Open
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High-Resolution Structure of ClpC1-Rufomycin and Ligand Binding Studies Provide a Framework to Design and Optimize Anti-Tuberculosis Leads Open
Addressing the urgent need to develop novel drugs against drug-resistant Mycobacterium tuberculosis ( M. tb) strains, ecumicin (ECU) and rufomycin I (RUFI) are being explored as promising new leads targeting cellular proteostasis via the c…
Rufomycin Targets ClpC1 Proteolysis in Mycobacterium tuberculosis and M. abscessus Open
ClpC1 is an emerging new target for the treatment of Mycobacterium tuberculosis infections, and several cyclic peptides (ecumicin, cyclomarin A, and lassomycin) are known to act on this target. This study identified another group of peptid…
Structures of the<i>Mycobacterium tuberculosis</i>GlpX protein (class II fructose-1,6-bisphosphatase): implications for the active oligomeric state, catalytic mechanism and citrate inhibition Open
The crystal structures of native class II fructose-1,6-bisphosphatase (FBPaseII) from Mycobacterium tuberculosis at 2.6 Å resolution and two active-site protein variants are presented. The variants were complexed with the reaction product …