Ning Xu
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View article: Metabolic Engineering of Yeasts: A Key Cell Factory Platform for Advanced Biomanufacturing
Metabolic Engineering of Yeasts: A Key Cell Factory Platform for Advanced Biomanufacturing Open
With mounting concerns over finite fossil fuel reserves and climate change, increasing attention is being paid to an emerging bioeconomy [...]
View article: Investigation of the effects of Si-A/PUE@HA hydrogels on the osteochondral defect microenvironment based on single-cell RNA sequencing
Investigation of the effects of Si-A/PUE@HA hydrogels on the osteochondral defect microenvironment based on single-cell RNA sequencing Open
Osteochondral defects pose significant challenges in joint health, leading to pain, decreased mobility, and substantial healthcare costs due to surgical interventions. This study aimed to develop and evaluate Si-A/PUE@HA composite hydrogel…
View article: Single-cell atlas of reproductive endocrine organs reveals transcriptomic responses to type 1 diabetes mellitus in non-human primate
Single-cell atlas of reproductive endocrine organs reveals transcriptomic responses to type 1 diabetes mellitus in non-human primate Open
Type 1 diabetes mellitus characterized by insulin deficiency and hyperglycemia is associated with female subfertility. However, how hyperglycemia affects the hypothalamic-pituitary-ovarian-uterine axis remains poorly understood. In this st…
View article: Frontiers in Innovative Materials and Technologies for Oil–Water Separation
Frontiers in Innovative Materials and Technologies for Oil–Water Separation Open
Oil-contaminated wastewater represents a major source of industrial pollution, posing significant risks to both the environment and human health. Traditional oil–water separation methods, including gravity separation, centrifugal separatio…
View article: Gefitinib Facilitates Bone Fracture Healing <i>via</i> Inhibition of the EGFR Pathway and Counteracting SOX9-driven Bone Metabolic Reprogramming
Gefitinib Facilitates Bone Fracture Healing <i>via</i> Inhibition of the EGFR Pathway and Counteracting SOX9-driven Bone Metabolic Reprogramming Open
Gefitinib enhances bone fracture healing by modulating lipid metabolism through SOX9, suggesting its potential as a therapeutic agent for improving fracture outcomes.
View article: Assessment of Fish Species Biodiversity in the Yong River Basin Based on Environmental DNA Metabarcoding
Assessment of Fish Species Biodiversity in the Yong River Basin Based on Environmental DNA Metabarcoding Open
Fish in the Yong River basin have been significantly impacted by pollution, habitat modification and overfishing. In order to facilitate the recovery of freshwater biodiversity, a fishing ban has been implemented in the Yong River basin si…
View article: Sestrin2 balances mitophagy and apoptosis through the PINK1-Parkin pathway to attenuate severe acute pancreatitis
Sestrin2 balances mitophagy and apoptosis through the PINK1-Parkin pathway to attenuate severe acute pancreatitis Open
Mitophagy serves as a mitochondrial quality control mechanism to maintain the homeostasis of mitochondria and the intracellular environment. Studies have shown that there is a close relationship between mitophagy and apoptosis. Sestrin2 (S…
View article: Thermo-adaptive evolution of Corynebacterium glutamicum reveals the regulatory functions of fasR and hrcA in heat tolerance
Thermo-adaptive evolution of Corynebacterium glutamicum reveals the regulatory functions of fasR and hrcA in heat tolerance Open
This work systematically reveals the thermotolerance mechanisms of Corynebacterium glutamicum and opens a new avenue for revolutionizing the design of cell factories to boost fermentation efficiency.
View article: Clinical Outcomes of Full‐Endoscopic Visualized Foraminoplasty and Discectomy for Lumbar Disc Herniation with Bilateral Radiculopathy
Clinical Outcomes of Full‐Endoscopic Visualized Foraminoplasty and Discectomy for Lumbar Disc Herniation with Bilateral Radiculopathy Open
Objective The treatment of lumbar disc herniation (LDH) with bilateral radiculopathy using transforaminal endoscopic lumbar discectomy (TELD) remains challenging, especially at the L5/S1 level with narrow foramen or high iliac crest. Full‐…
View article: A passive temperature regulator
A passive temperature regulator Open
Maintaining stable temperatures is crucial for civilization, but it typically requires substantial energy consumption, contributing to significant carbon footprints. Despite advancements in passive heating/cooling technologies, achieving p…
View article: Pharmacokinetic/Pharmacodynamic modelling of Saxagliptin and its active metabolite, 5-hydroxy Saxagliptin in rats with Type 2 Diabetes Mellitus
Pharmacokinetic/Pharmacodynamic modelling of Saxagliptin and its active metabolite, 5-hydroxy Saxagliptin in rats with Type 2 Diabetes Mellitus Open
Background and purposes It is unclear whether the parent Saxagliptin (SAX) in vivo is the same as that in vitro, which is twice that of 5-hydroxy Saxagliptin (5-OH SAX). This study is to construct a Pharmacokinetic-Pharmacodynamic (PK-PD) …
View article: Relationship between circulating thrombospondin‐1 <scp>messenger ribonucleic acid</scp> and <scp>microribonucleic acid</scp>‐194 levels in Chinese patients with type 2 diabetic kidney disease: The outcomes of a case–control study
Relationship between circulating thrombospondin‐1 <span>messenger ribonucleic acid</span> and <span>microribonucleic acid</span>‐194 levels in Chinese patients with type 2 diabetic kidney disease: The outcomes of a case–control study Open
Aims/Introduction We investigated the relationship of circulating TSP‐1 mRNA and miR‐194 with diabetic kidney disease’s degree. Materials and Methods We enrolled 167 hospitalized type 2 diabetes patients in the endocrinology department. Pa…
View article: Knowledge, attitude and practice of poststroke depression among patients with poststroke depression and their family members in Heilongjiang Province, China: a cross-sectional study
Knowledge, attitude and practice of poststroke depression among patients with poststroke depression and their family members in Heilongjiang Province, China: a cross-sectional study Open
Objective This study aimed to investigate the knowledge, attitude and practice (KAP) of poststroke depression (PSD) among patients with PSD and their family members. Design Web-based cross-sectional study. Setting This study was conducted …
View article: Integrated micro/nano drug delivery system based on magnetically responsive phase-change droplets for ultrasound theranostics
Integrated micro/nano drug delivery system based on magnetically responsive phase-change droplets for ultrasound theranostics Open
Phase-change droplets (PCDs) are intelligent responsive micro and nanomaterials developed based on micro/nano bubbles. Subject to external energy inputs such as temperature and ultrasound, the core substance, perfluorocarbon (PFC), undergo…
View article: Comparative genomics of macaques and integrated insights into genetic variation and population history
Comparative genomics of macaques and integrated insights into genetic variation and population history Open
The crab-eating macaques ( Macaca fascicularis ) and rhesus macaques ( M. mulatta ) are widely studied nonhuman primates in biomedical and evolutionary research. Despite their significance, the current understanding of the complex genomic …
View article: Neck management in metastatic cutaneous squamous cell carcinoma of the head and neck
Neck management in metastatic cutaneous squamous cell carcinoma of the head and neck Open
Objective Optimal neck management remains unclear in head and neck cutaneous squamous cell carcinoma (HNcSCC) with parotid metastasis. Our goal was to compare the impact of different cervical treatments on HNcSCC with parotid metastasis. M…
View article: Longitudinal Distribution Map of the Active Components and Endophytic Fungi in Angelica sinensis (Oliv.) Diels Root and Their Potential Correlations
Longitudinal Distribution Map of the Active Components and Endophytic Fungi in Angelica sinensis (Oliv.) Diels Root and Their Potential Correlations Open
The three distinct medicinal parts of Angelica sinensis (Oliv.) Diels (Ang) roots are the head, body, and tail (ARH, ARB, and ART, respectively). How endophytic fungi shape the differences in metabolic components among these parts remains …
View article: Dynamics of microbial communities, flavor, and physicochemical properties of kombucha-fermented Sargassum fusiforme beverage during fermentation
Dynamics of microbial communities, flavor, and physicochemical properties of kombucha-fermented Sargassum fusiforme beverage during fermentation Open
In this study, a novel kombucha-fermented Sargassum fusiforme beverage was prepared, and physicochemical properties, volatile flavor compounds, and microbial communities during the beverage fermentation were investigated. The results indic…
View article: Comparative transcriptome analysis between rhesus macaques (<i>Macaca mulatta</i>) and crab-eating macaques (<i>M. fascicularis</i>)
Comparative transcriptome analysis between rhesus macaques (<i>Macaca mulatta</i>) and crab-eating macaques (<i>M. fascicularis</i>) Open
Understanding gene expression variations between species is pivotal for deciphering the evolutionary diversity in phenotypes. Rhesus macaques ( Macaca mulatta, MMU) and crab-eating macaques ( M. fascicularis, MFA) serve as crucial nonhuman…
View article: The sonic hedgehog pathway suppresses oxidative stress and senescence in nucleus pulposus cells to alleviate intervertebral disc degeneration via GPX4
The sonic hedgehog pathway suppresses oxidative stress and senescence in nucleus pulposus cells to alleviate intervertebral disc degeneration via GPX4 Open
Disruption of intervertebral disc (IVD) homeostasis caused by oxidative stress and nucleus pulposus cell (NPC) senescence is a main cause of intervertebral disc degeneration (IDD). The sonic hedgehog (Shh) pathway plays an important role i…
View article: Characterizing bacterial and fungal communities along the longitudinal axis of the intestine in cynomolgus monkeys
Characterizing bacterial and fungal communities along the longitudinal axis of the intestine in cynomolgus monkeys Open
The gut microbiota develops specialized local communities along the gastrointestinal (GI) tract of the host. Among these microbes, intestinal bacteria and fungi interact closely with the host and play vital roles in their health. However, …
View article: Fotagliptin monotherapy with alogliptin as an active comparator in patients with uncontrolled type 2 diabetes mellitus: a randomized, multicenter, double-blind, placebo-controlled, phase 3 trial
Fotagliptin monotherapy with alogliptin as an active comparator in patients with uncontrolled type 2 diabetes mellitus: a randomized, multicenter, double-blind, placebo-controlled, phase 3 trial Open
Background Dipeptidyl peptidase-4 inhibitors (DPP-4i) have become firmly established in treatment algorithms and national guidelines for improving glycemic control in type 2 diabetes mellitus (T2DM).To report the findings from a multicente…
View article: Targeted C-to-T and A-to-G dual mutagenesis system for RhtA transporter <i>in vivo</i> evolution
Targeted C-to-T and A-to-G dual mutagenesis system for RhtA transporter <i>in vivo</i> evolution Open
T7 RNA polymerase (T7RNAP) has been fused with cytosine or adenine deaminase individually, enabling in vivo C-to-T or A-to-G transitions on DNA sequence downstream of T7 promoter, and greatly accelerated directed protein evolution. However…
View article: Transcription factor OxyR regulates sulfane sulfur removal and L-cysteine biosynthesis in <i>Corynebacterium glutamicum</i>
Transcription factor OxyR regulates sulfane sulfur removal and L-cysteine biosynthesis in <i>Corynebacterium glutamicum</i> Open
Sulfane sulfur, a collective term for hydrogen polysulfide and organic persulfide, often damages cells at high concentrations. Cells can regulate intracellular sulfane sulfur levels through specific mechanisms, but these mechanisms are unc…
View article: Comparative transcriptome in rhesus macaques and crab-eating macaques
Comparative transcriptome in rhesus macaques and crab-eating macaques Open
Understanding the variations in gene expression between species is pivotal for deciphering the evolutionary diversity in phenotypes. Rhesus macaques and crab-eating macaques serve as crucial nonhuman primate biomedical models with differen…
View article: Effect of scalp acupuncture combined with low frequency repetitive transcranial magnetic stimulation on brain function of pediatric patients with spastic cerebral palsy
Effect of scalp acupuncture combined with low frequency repetitive transcranial magnetic stimulation on brain function of pediatric patients with spastic cerebral palsy Open
To observe the changes of Electroencephalogram (EEG) spectrum in children with spastic cerebral palsy before and after treatment, and to analyze the effects of scalp acupuncture combined with low-frequency repetitive transcranial magnetic …
View article: Transcriptome profiles of high-lysine adaptation reveal insights into osmotic stress response in Corynebacterium glutamicum
Transcriptome profiles of high-lysine adaptation reveal insights into osmotic stress response in Corynebacterium glutamicum Open
Corynebacterium glutamicum has been widely and effectively used for fermentative production of l -lysine on an industrial scale. However, high-level accumulation of end products inevitably leads to osmotic stress and hinders further increa…