Ninghan Yang
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View article: <i>Toxoplasma</i> GRA15 Activates the NF-κB Pathway through Interactions with TNF Receptor-Associated Factors
<i>Toxoplasma</i> GRA15 Activates the NF-κB Pathway through Interactions with TNF Receptor-Associated Factors Open
The parasite Toxoplasma can cause birth defects and severe disease in immunosuppressed patients. Strain differences in pathogenicity exist, and these differences are due to polymorphic effector proteins that Toxoplasma secretes into the ho…
View article: Use of Expression Profiles of HBV-DNA Integrated Into Genomes of Hepatocellular Carcinoma Cells to Select T Cells for Immunotherapy
Use of Expression Profiles of HBV-DNA Integrated Into Genomes of Hepatocellular Carcinoma Cells to Select T Cells for Immunotherapy Open
HCC cells contain short segments of integrated HBV-DNA that encodes epitopes that are recognized by and activate T cells. HBV transcriptomes of these cells could be used to engineer T cells for personalized immunotherapy. This approach mig…
View article: Spatiotemporal Differences in Presentation of CD8 T Cell Epitopes during Hepatitis B Virus Infection
Spatiotemporal Differences in Presentation of CD8 T Cell Epitopes during Hepatitis B Virus Infection Open
The inability of patients with chronic HBV infection to clear HBV is associated with defective HBV-specific CD8 + T cells. Hence, the majority of immunotherapy developments focus on HBV-specific T cell function restoration. However, knowle…
View article: Transcriptional Analysis of Murine Macrophages Infected with Different <i>Toxoplasma</i> Strains Identifies Novel Regulation of Host Signaling Pathways
Transcriptional Analysis of Murine Macrophages Infected with Different <i>Toxoplasma</i> Strains Identifies Novel Regulation of Host Signaling Pathways Open
Most isolates of Toxoplasma from Europe and North America fall into one of three genetically distinct clonal lineages, the type I, II and III lineages. However, in South America these strains are rarely isolated and instead a great variety…
View article: Identification and characterization of Toxoplasma gondii effectors that modulate innate immune pathways
Identification and characterization of Toxoplasma gondii effectors that modulate innate immune pathways Open
Thesis: Ph. D. in Microbiology, Massachusetts Institute of Technology, Department of Biology, 2015.