Explanipedia

Diurnal Light Exposure and Rest-Activity Rhythms in Relation to MASLD: Insights From 2 Nationwide Cohort Studies Open

Hanzhang Wu, Wei Wang, Bingtao Weng, Jiahe Wei, Ningjian Wang , et al. · 2025

Context Circadian rhythms may influence metabolic dysfunction–associated steatotic liver disease (MASLD), but the effect of personal light exposure and rest-activity rhythms on MASLD risk remain unclear. Objective To examine the associatio…

The role of circadian rest-activity rhythm for the link between 25-hydroxyvitamin D and type 2 diabetes: a cohort study Open

Hanzhang Wu, Hongliang Feng, Jiahe Wei, Shuai Wang, Liangkai Chen , et al. · 2025

Background Temporal distribution and amplitude of physical activity/inactivity in 24 h known as circadian rest-activity rhythm may predict the risk of various metabolic diseases, including type 2 diabetes (T2D), yet the mechanisms behind t…

Integrative proteomic analysis provides novel therapeutic insights for etiological subtypes of diabetes Open

Jiahe Wei, Hanzhang Wu, Ningjian Wang, Jiahao Zhu, Ranjit Mohan Anjana , et al. · 2025

Aims Type 2 diabetes (T2D) is a highly heterogeneous disease characterised by subtypes with variations in aetiology, disease progression, and risk of complications. However, potential drug targets for these subtypes have not been explored.…

The hepatic metabolism pattern of MASLD in rats with double burden of malnutrition Open

Yuying Wang, Heng Wan, Xinying Gu, Kun Zhang, Bin Wang , et al. · 2025

Association between total and regional body fat measured by dual-energy X-ray absorptiometry and apolipoprotein B Open

Chi Chen, Yan Gu, Junfei Xu, Yanyan Xiao, Chao Wang , et al. · 2025

Proteomic Signatures Underlying Sleep, Circadian Activity Patterns, and Major Chronic Diseases Open

Jiahe Wei, Hanzhang Wu, Ying Zheng, Bingtao Weng, Yao Xiao , et al. · 2025

Rest‐activity rhythm and sleep may serve as potential intervention targets for a variety of diseases. However, the underlying biological mechanisms of rest‐activity rhythm, sleep, and their proteomic associations with multiple diseases rem…

L-Phenylalanine promotes liver steatosis by inhibiting BNIP3-mediated mitophagy Open

Ying Sun, Lingli Cai, Bowei Yu, Haojie Zhang, Ziteng Zhang , et al. · 2025

Highlights of the current issue Open

Ningjian Wang, Anoop Misra · 2025

Frailty, genetic predisposition, and incident chronic kidney disease Open

Shanshan Zou, Ying Sun, Yinuo Zhou, Bowei Yu, Jiang Li , et al. · 2025

Frailty is common among individuals with chronic kidney disease (CKD), whereas its impact on incident CKD risk remains unknown. This study aimed to prospectively evaluate the association between frailty and incident CKD risk, exploring the…

The Identification of Biomarkers and Therapeutic Targets for Diabetic Kidney Disease by Integrating the Proteome with the Genome Open

Yuefeng Yu, Jiang Li, Bowei Yu, Yuetian Yu, Ying Sun , et al. · 2025

Background: The blood proteome is a major source of biomarkers and therapeutic targets. We conducted a proteome-wide Mendelian randomization (MR) study to identify cardiometabolic protein markers for diabetic kidney disease (DKD). Methods:…

Association of iodized salt intake with the risk of physical frailty in patients with type 2 diabetes Open

Jiang Li, Jie Li, Ying Sun, Yanqi Fu, Wenqi Shen , et al. · 2025

Non-iodized salt consumed and low UIC were associated with an increased risk of frailty in diabetes, particularly in those with high TSH and low FT4. Maintaining adequate iodine intake is critically important for preventing frailty in diab…

Domestic water hardness, genetic risk, and distinct phenotypes of cardiovascular disease Open

Feng Tian, Genfeng Yu, Mengyuan Yang, Ying Sun, Zihao Gui , et al. · 2025

Potential U-shaped associations between domestic water hardness and incident AF across varying levels of genetic risk were found. Hard water (121-180 mg/L) may offer the most benefits compared to soft water when considering overall cardiov…

Clonal hematopoiesis of indeterminate potential and the risk of autoimmune diseases Open

Hanzhang Wu, Jiahe Wei, Yuefeng Yu, Ningjian Wang, Xiao Tan · 2025

Background Clonal hematopoiesis of indeterminate potential (CHIP), characterized by the age‐related expansion of blood cells carrying preleukemic mutations, is associated with immune aging. This study aimed to investigate the association b…

Association of polysocial risk score, cardiovascular health status, and the risk of premature mortality: Findings from the UK Biobank Open

Wenqi Shen, Lingli Cai, Bin Wang, Li Jiang, Ying Sun , et al. · 2025

Clonal hematopoiesis of indeterminate potential, health indicators, and risk of cardiovascular diseases among patients with diabetes: a prospective cohort study Open

Ying Sun, Yuefeng Yu, Lingli Cai, Bowei Yu, Wenying Xiao , et al. · 2025

Genetic and Plasma Proteomic Approaches to Identify Therapeutic Targets for Graves’ Disease and Graves’ Ophthalmopathy Open

Chao Ke, Yuefeng Yu, Jiang Li, Yuetian Yu, Ying Sun , et al. · 2025

By synthesizing proteomic and genetic data, we identified several protein biomarkers for GD, with one linked to both GD and GO and two other protein biomarkers specific to GO onset, which provides valuable insights into the etiology and po…

Clonal haematopoiesis of indeterminate potential and risk of microvascular complications among individuals with type 2 diabetes: a cohort study Open

Jiahe Wei, Yuefeng Yu, Hanzhang Wu, Yingjun Li, Ningjian Wang , et al. · 2025

Clonal haematopoiesis of indeterminate potential (CHIP) is associated with macrovascular diseases, including coronary artery disease and stroke. However, the effects of CHIP on microvascular complication have not been evaluated in individu…

Clonal haematopoiesis of indeterminate potential and risk of microvascular complications among individuals with type 2 diabetes: a cohort study Open

Jiahe Wei, Yuefeng Yu, Hanzhang Wu, Yingjun Li, Ningjian Wang , et al. · 2025

Clonal haematopoiesis of indeterminate potential (CHIP) is associated with macrovascular diseases, including coronary artery disease and stroke. However, the effects of CHIP on microvascular complication have not been evaluated in individu…

Pancreatic Fat Infiltration and Diabetic Kidney Disease: CT Imaging and Genetic Analysis Open

Yuefeng Yu, Yuetian Yu, Man Li, Yuying Wang, Bin Wang , et al. · 2025

High Prevalence of CKM Syndrome in the US and Chinese Population with MASLD Open

Dongmei Wang, Qingtao Yu, Shze Jer HU, Nanfang Yao, Ying Sun , et al. · 2025

Choline Metabolites, Genetic Susceptibility, and Incident Heart Failure Open

Jie Jack Li, Jiang Li, Ying Sun, Yanqi Fu, Xiao Tan , et al. · 2024

Early-life famine exposure, genetic susceptibility and risk of MAFLD in adulthood Open

Yuying Wang, Kun Zhang, Bin Wang, Bing Yu, Ziteng Zhang , et al. · 2024

Adequate sleep duration accentuates the effect of glucagon-like peptide-1 receptor variant on HbA1c: A gene-environment interaction study Open

Jiahe Wei, Hanzhang Wu, Ying Zheng, Ningjian Wang, Christian Benedict , et al. · 2024

Combining GLP1R agonists with adequate sleep may provide additional benefits for glycemic control in clinical practice.

Nuclear magnetic resonance-based metabolomics with machine learning for predicting progression from prediabetes to diabetes Open