Ning Zhao
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View article: Interpretable Multiomics Models for Predicting Surgical Interventions and Blood Transfusion Requirements in Traumatic Brain Injury
Interpretable Multiomics Models for Predicting Surgical Interventions and Blood Transfusion Requirements in Traumatic Brain Injury Open
Accurately predicting surgical and transfusion needs in traumatic brain injury (TBI) patients remains challenging in emergency settings. We developed multiomics data fusion (MDF) models integrating clinical biomarkers, neural radiological …
View article: Case Report: Use of submental artery perforator flap for reconstructing defects following sinonasal tumor resection
Case Report: Use of submental artery perforator flap for reconstructing defects following sinonasal tumor resection Open
Background Sinonasal malignancies (SNMs) invading orbital and maxillofacial structures require complex reconstructive techniques. The submental artery perforator flap (SMAPF) provides a promising reconstructive option due to its vascular r…
View article: How does regional financial development affect the investment and financing behaviors of low-altitude economy enterprises? An empirical study based on the expansion of city commercial banks
How does regional financial development affect the investment and financing behaviors of low-altitude economy enterprises? An empirical study based on the expansion of city commercial banks Open
View article: Artificial intelligence-assisted psychological intervention mechanisms for university students in the context of new media technologies: an analysis based on data from the national institute of mental health
Artificial intelligence-assisted psychological intervention mechanisms for university students in the context of new media technologies: an analysis based on data from the national institute of mental health Open
Introduction With the pervasive influence of new media, mental health issues among college students have become increasingly prominent, manifested in high rates of emotional disorders, delayed interventions, uneven resource allocation, and…
View article: Astragaloside IV combined with quercetin attenuates silica-induced pulmonary fibrosis by promoting autophagy and suppressing pyroptosis
Astragaloside IV combined with quercetin attenuates silica-induced pulmonary fibrosis by promoting autophagy and suppressing pyroptosis Open
ASV combined with QUE could alleviate silica-induced pulmonary inflammation and fibrosis in rats, with the protective mechanism potentially mediated through enhanced autophagy activation and suppressed pyroptosis pathway.
View article: Prediction of the Effects of Pulsating Hydraulic Fracturing on the Porous Structure and Permeability of Coal Based on NMR and AE Spectra
Prediction of the Effects of Pulsating Hydraulic Fracturing on the Porous Structure and Permeability of Coal Based on NMR and AE Spectra Open
Pulsating hydraulic fracturing has been an environmentally friendly method to improve the permeability of rock formations to stimulate gas production and reduce hazard risks. It has the advantage of fracturing the reservoir with lower crac…
View article: iRGD mediated pH-responsive mesoporous silica enhances drug accumulation in tumors
iRGD mediated pH-responsive mesoporous silica enhances drug accumulation in tumors Open
The limited penetration of nanocarriers into tumors and the slow release of drugs from these carriers to tumor cells are significant challenges in cancer therapy. In this study, we developed a novel drug delivery carrier derived from mesop…
View article: Health Economics Disparities, Inequality and Inequity In Healthcare Services: Today's Reality and Tomorrow's Challenges
Health Economics Disparities, Inequality and Inequity In Healthcare Services: Today's Reality and Tomorrow's Challenges Open
it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed.The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge.Front…
View article: In-depth exploration on the effects of organic nitrogen addition during different fermentation periods on the quality of cider
In-depth exploration on the effects of organic nitrogen addition during different fermentation periods on the quality of cider Open
Nitrogen is an essential element for the growth and metabolism of Saccharomyces cerevisiae, and has a great impact on the quality of cider. In this study, the effects of organic nitrogen addition at different stages of fermentation process…
View article: Exploring the growth characteristics of Alicyclobacillus acidoterrestris for controlling juice spoilage with zero additives
Exploring the growth characteristics of Alicyclobacillus acidoterrestris for controlling juice spoilage with zero additives Open
Fruit juice spoilage that caused by contaminated Alicyclobacillus has brought huge losses to beverage industry worldwide. Thus, it is very essential to understand the growth and metabolism processing of Alicyclobacillus acidoterr…
View article: Structural analysis, nutritional evaluation, and flavor characterization of parched rice made from proso millet
Structural analysis, nutritional evaluation, and flavor characterization of parched rice made from proso millet Open
This study investigated the structure and quality characteristics of hard and crispy parched rice obtained from raw proso millet through steaming, roasting, and milling. Results showed that thermal treatment disrupted the structure of samp…
View article: Transcriptomic and Metabolomic Profiling Uncovers Response Mechanisms of Alicyclobacillus acidoterrestris DSM 3922 <sup>T</sup> to Acid Stress
Transcriptomic and Metabolomic Profiling Uncovers Response Mechanisms of Alicyclobacillus acidoterrestris DSM 3922 <sup>T</sup> to Acid Stress Open
Fruit juice spoilage caused by A. acidoterrestris contamination has become a major concern and challenge in the food industry, and this bacterium has been suggested as a target microbe in the design of the pasteurization process. However, …
View article: TXNIP inhibition in the treatment of type 2 diabetes mellitus: design, synthesis, and biological evaluation of quinazoline derivatives
TXNIP inhibition in the treatment of type 2 diabetes mellitus: design, synthesis, and biological evaluation of quinazoline derivatives Open
Thioredoxin interacting protein (TXNIP) is a potential drug target for type 2 diabetes mellitus (T2DM) treatment. A series of quinazoline derivatives were designed, synthesised, and evaluated to inhibit TXNIP expression and protect from pa…
View article: Density Functional Theory Study on the Coordination of Phenanthroline with Fe
Density Functional Theory Study on the Coordination of Phenanthroline with Fe Open
View article: Functional Morphology of the Antennae and Sensilla of Coeloides qinlingensis Dang et Yang (Hymenoptera: Braconidae)
Functional Morphology of the Antennae and Sensilla of Coeloides qinlingensis Dang et Yang (Hymenoptera: Braconidae) Open
Coeloides qinlingensis Dang et Yang, 1989 (Hymenoptera: Braconidae) is a biocontrol agent of several scolytid pine pests in Southwest China. We examined the fine morphology of the antennae of adult C. qinlingensis, as well as the type, sha…
View article: Stress-induced epinephrine promotes epithelial-to-mesenchymal transition and stemness of CRC through the CEBPB/TRIM2/P53 axis
Stress-induced epinephrine promotes epithelial-to-mesenchymal transition and stemness of CRC through the CEBPB/TRIM2/P53 axis Open
View article: The Mechanism of Action of Nanomaterials Loaded with Clarithromycin after Sinusitis Surgery under the Guidance of Dynamic Enhanced Scanning
The Mechanism of Action of Nanomaterials Loaded with Clarithromycin after Sinusitis Surgery under the Guidance of Dynamic Enhanced Scanning Open
This study was to explore the mechanism of action of nanomaterial-loaded clarithromycin (CLA) after sinusitis surgery. Under the guidance of dynamic enhanced scanning (DES). 120 patients with sinusitis admitted to the First Affiliated Hosp…
View article: Efficacy of intravitreal conbercept combined with panretinal photocoagulation for severe nonproliferative diabetic retinopathy without macular edema
Efficacy of intravitreal conbercept combined with panretinal photocoagulation for severe nonproliferative diabetic retinopathy without macular edema Open
AIM: To assess efficacy of intravitreal conbercept (IVC) injection in combination with panretinal photocoagulation (PRP) vs PRP alone in patients with severe nonproliferative diabetic retinopathy (SNPDR) without macular edema (ME). METHODS…
View article: Transcriptome-Based Selection and Validation of Reference Genes for Gene Expression Analysis of Alicyclobacillus acidoterrestris Under Acid Stress
Transcriptome-Based Selection and Validation of Reference Genes for Gene Expression Analysis of Alicyclobacillus acidoterrestris Under Acid Stress Open
Alicyclobacillus acidoterrestris is a major concern in fruit juice industry due to its spoilage potential of acidic fruit juice. Quantifying the expression levels of functional genes by real-time quantitative polymerase chain reaction (RT-…
View article: CUB domain containing protein 1 (CDPC1) is a target for radioligand therapy in castration resistant prostate cancer
CUB domain containing protein 1 (CDPC1) is a target for radioligand therapy in castration resistant prostate cancer Open
Purpose Radioligand therapy (RLT) is relatively unexplored in metastatic castration resistant prostate cancer (mCRPC), with much of the focus having been on bone seeking radionuclides and PSMA-directed RLT. Herein, we evaluated if CUB doma…
View article: Nitric oxide regulates perylenequinones biosynthesis in Shiraia bambusicola S4201 induced by hydrogen peroxide
Nitric oxide regulates perylenequinones biosynthesis in Shiraia bambusicola S4201 induced by hydrogen peroxide Open
Shiraia bambusicola has been used as a traditional Chinese medicine for a long history. Its major medicinal active metabolites are perylenequinones, including hypocrellin A, elsinochrome A and so on. At present, the fermentation yield of p…
View article: Ratiometric fluorescence probe of Cu<sup>2+</sup> and biothiols by using carbon dots and copper nanoclusters
Ratiometric fluorescence probe of Cu<sup>2+</sup> and biothiols by using carbon dots and copper nanoclusters Open
A dual-mechanism ratiometric fluorescent probe based on N-doped yellow fluorescent carbon dots (y-CDs) and blue fluorescent copper nanoclusters (CuNCs) was established for the first simultaneous determination of Cu 2+ and biothiols.
View article: Comprehensive RNA-Seq profiling of the lung transcriptome of Bashbay sheep in response to experimental Mycoplasma ovipneumoniae infection
Comprehensive RNA-Seq profiling of the lung transcriptome of Bashbay sheep in response to experimental Mycoplasma ovipneumoniae infection Open
The Bashbay sheep (Ovis aries), an indigenous breed of Xinjiang, China, has many excellent characteristics. It is resistant to Mycoplasma ovipneumoniae infection, the causative agent of mycoplasma ovipneumonia, a chronic respiratory diseas…
View article: Reactive oxygen species and enzyme dual-responsive biocompatible drug delivery system for targeted tumor therapy
Reactive oxygen species and enzyme dual-responsive biocompatible drug delivery system for targeted tumor therapy Open
View article: Comprehensive RNA-Seq profiling of the lung transcriptome of Argali hybrid sheep in response to experimental Mycoplasma ovipneumoniae infection
Comprehensive RNA-Seq profiling of the lung transcriptome of Argali hybrid sheep in response to experimental Mycoplasma ovipneumoniae infection Open
The situation that ciliary movement is significantly inhibited and B cells in immunodeficiency are possibly the most important reason why Argali hybrid sheep are susceptible to MO.
View article: Genome Sequencing and Analysis of the Hypocrellin-Producing Fungus Shiraia bambusicola S4201
Genome Sequencing and Analysis of the Hypocrellin-Producing Fungus Shiraia bambusicola S4201 Open
Shiraia bambusicola has long been used as a traditional Chinese medicine and its major medicinal active metabolite is hypocrellin, which exhibits outstanding antiviral and antitumor properties. Here we report the 32 Mb draft genome …
View article: Unique Double Carbon Protection Structured Co&lt;sub&gt;3&lt;/sub&gt;O&lt;sub&gt;4&lt;/sub&gt; Anode for Lithium Ion Battery
Unique Double Carbon Protection Structured Co<sub>3</sub>O<sub>4</sub> Anode for Lithium Ion Battery Open
In this study, novel Carbon aerogel (CA)/Co3O4/Carbon (C) composites with a double protective structure are synthesized through a solvothermal method and in-situ polymerization. The morphology and structure are characterized by X-ray diffr…
View article: Anti-resorptive effects of cementocytes during orthodontic tooth movement
Anti-resorptive effects of cementocytes during orthodontic tooth movement Open
Purpose: To investigate the mechanism involved in the anti-resorptive effect of cementocytes during orthodontic tooth movement in mice and human specimens.Methods: The morphology, molecular structure and biological expression of cellular c…
View article: Theranostic nanoparticles enhance the response of glioblastomas to radiation
Theranostic nanoparticles enhance the response of glioblastomas to radiation Open
Despite considerable progress with our understanding of glioblastoma multiforme (GBM) and the precise delivery of radiotherapy, the prognosis for GBM patients is still unfavorable with tumor recurrence due to radioresistance being a major …
View article: Diallyl sulfide treatment protects against acetaminophen-/carbon tetrachloride-induced acute liver injury by inhibiting oxidative stress, inflammation and apoptosis in mice
Diallyl sulfide treatment protects against acetaminophen-/carbon tetrachloride-induced acute liver injury by inhibiting oxidative stress, inflammation and apoptosis in mice Open
The purpose of the present study was to investigate the effects and underlying mechanisms of diallyl sulfide (DAS), an organosulfur compound extracted from garlic, on drug-induced or chemical-induced liver injury caused by acetaminophen (A…