Ningxin Qin
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View article: Constructing a nomogram for ICSI-ET assisted reproductive outcomes in infertile men based on lifestyle and sperm quality: a multicenter retrospective survey
Constructing a nomogram for ICSI-ET assisted reproductive outcomes in infertile men based on lifestyle and sperm quality: a multicenter retrospective survey Open
Objective To identify risk factors influencing clinical pregnancy outcomes in infertile men undergoing intracytoplasmic sperm injection (lCSl) and to establish and validate a nomogram prediction model. Methods A total of 1,037 infertile me…
View article: Predictive model of sperm DNA fragmentation in infertile men based on lifestyle factors
Predictive model of sperm DNA fragmentation in infertile men based on lifestyle factors Open
Objective This study aimed to investigate the influence of lifestyle factors on the sperm DNA fragmentation index (DFI) in infertile men, and to develop and validate a predictive model for identifying individuals at risk of abnormal DFI. M…
View article: Development and validation of a nomogram model for sleep disorders in patients with recurrent implantation failure based on physiological and lifestyle factors
Development and validation of a nomogram model for sleep disorders in patients with recurrent implantation failure based on physiological and lifestyle factors Open
Objective To establish and validate a nomogram model for the quality of sleep in patients with recurrent implantation failure (RIF) and to evaluate its performance. Methods From January 2023 to June 2023, 484 RIF patients who underwent ART…
View article: Construction of a Prediction Model for Sleep Quality in Embryo Repeated Implantation Failure Patients Undergoing Assisted Reproductive Technology Based on Machine Learning: A Single-Center Retrospective Study
Construction of a Prediction Model for Sleep Quality in Embryo Repeated Implantation Failure Patients Undergoing Assisted Reproductive Technology Based on Machine Learning: A Single-Center Retrospective Study Open
The RF model is the optimal model for predicting the sleep quality of RIF patients. Its sleep quality is not only affected by physiological factors, but also by psychological and lifestyle factors. Medical personnel should implement interv…
View article: Effect of Donor Sperm on Quality of Life in Patients with Severe Oligoasthenosperm After ICSI Failure
Effect of Donor Sperm on Quality of Life in Patients with Severe Oligoasthenosperm After ICSI Failure Open
The use of donor sperm for pregnancy after ICSI failure in patients with severe oligoasthenospermia has a great impact on their reproductive life, sleep quality and erectile function. Medical staff should pay attention to the quality of li…
View article: Correlation between cardiometabolic index and female infertility: a cross-sectional analysis
Correlation between cardiometabolic index and female infertility: a cross-sectional analysis Open
View article: Advanced paternal age exacerbates neuroinflammation in offspring via m6A modification-mediated intergenerational inheritance
Advanced paternal age exacerbates neuroinflammation in offspring via m6A modification-mediated intergenerational inheritance Open
View article: Association between cardiometabolic index and female infertility: a cross-sectional analysis
Association between cardiometabolic index and female infertility: a cross-sectional analysis Open
Background Adverse lipid profile leads to female infertility. The correlation between the cardiometabolic index (CMI) and female infertility merits further investigation. Methods The data for this study were acquired from the 2013–2020 Nat…
View article: Novel Loss-of-Function SYCP2 Variants in Infertile Males Upgrade the Gene–Disease Clinical Validity Classification for SYCP2 and Male Infertility to Strong
Novel Loss-of-Function SYCP2 Variants in Infertile Males Upgrade the Gene–Disease Clinical Validity Classification for SYCP2 and Male Infertility to Strong Open
Male infertility affects approximately 7% of the male population, and about 15% of these cases are predicted to have a genetic etiology. One gene implicated in autosomal dominant male infertility, SYCP2, encodes a protein critical for the …
View article: Analysis of risk factors related to assisted reproduction and assisted pregnancy outcomes in infertile men
Analysis of risk factors related to assisted reproduction and assisted pregnancy outcomes in infertile men Open
Objective This study investigated the risk factors of assisted pregnancy outcomes in infertile men receiving assisted reproductive treatment and established a risk prediction model. Methods A cross-sectional survey was conducted on 1037 in…
View article: Analysis of influencing factors of assisted reproduction and assisted pregnancy outcome of infertile male based on Logistic Regression and Decision Tree Model
Analysis of influencing factors of assisted reproduction and assisted pregnancy outcome of infertile male based on Logistic Regression and Decision Tree Model Open
Objective: To study the influencing factors of assisted pregnancy outcome in infertile men receiving assisted reproduction. Design: From January 2023 to June 2023, a total of 1037 infertile men who planned to undergo IVF/ICSI-ET assisted p…
View article: Sperm morphological abnormalities in autosomal dominant polycystic kidney disease are associated with the Hippo signaling pathway via PC1
Sperm morphological abnormalities in autosomal dominant polycystic kidney disease are associated with the Hippo signaling pathway via PC1 Open
Background Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary kidney disorder mostly caused by mutations in PKD1 or PKD2 genes. Here, we report thirteen ADPKD males with infertility and investigated the sperm morphologica…
View article: Effect of frozen-thawed embryo transfer on metabolism of children in early childhood
Effect of frozen-thawed embryo transfer on metabolism of children in early childhood Open
Background: As a routine procedure in assisted reproductive technology (ART), it is crucial to assess the safety of frozen and thawed embryo transfer (FET). We aimed to investigate the metabolic profile of children conceived through FET be…
View article: Associations of Sperm mtDNA Copy Number, DNA Fragmentation Index, and Reactive Oxygen Species With Clinical Outcomes in ART Treatments
Associations of Sperm mtDNA Copy Number, DNA Fragmentation Index, and Reactive Oxygen Species With Clinical Outcomes in ART Treatments Open
Recent studies have suggested that sperm mitochondrial DNA copy number (mtDNA-CN), DNA fragmentation index (DFI), and reactive oxygen species (ROS) content are crucial to sperm function. However, the associations between these measurements…
View article: Circulating Innate Lymphoid Cells Exhibit Distinctive Distribution During Normal Pregnancy
Circulating Innate Lymphoid Cells Exhibit Distinctive Distribution During Normal Pregnancy Open
Over the past decades, the investigation of innate lymphoid cells (ILCs) has revealed their significance in successful pregnancy. Sex hormones, such as estradiol and progesterone, show specific changes during pregnancy and modulate both ad…
View article: Anxiety and depression-like behaviours are more frequent in aged male mice conceived by ART compared with natural conception
Anxiety and depression-like behaviours are more frequent in aged male mice conceived by ART compared with natural conception Open
The number of children born after assisted reproductive technology (ART) is accumulating rapidly, and the health problems of the children are extensively concerned. This study aims to evaluate whether ART procedures alter behaviours in mal…
View article: Different Strategies of Preimplantation Genetic Testing for Aneuploidies in Women of Advanced Maternal Age: A Systematic Review and Meta-Analysis
Different Strategies of Preimplantation Genetic Testing for Aneuploidies in Women of Advanced Maternal Age: A Systematic Review and Meta-Analysis Open
Background: Preimplantation genetic testing for aneuploidies (PGT-A) is widely used in women of advanced maternal age (AMA). However, the effectiveness remains controversial. Method: We conducted a comprehensive literature review comparing…
View article: Associations of Sperm mtDNA copy number, DNA fragmentation index, and reactive oxygen species with clinical outcomes in ART treatments
Associations of Sperm mtDNA copy number, DNA fragmentation index, and reactive oxygen species with clinical outcomes in ART treatments Open
Background Except for sperm parameters (sperm concentration, motility, and morphology), sperm mitochondria DNA copy number (mtDNA-CN), DNA fragmentation index (DFI), and reactive oxygen species (ROS) content are essential characteristics f…
View article: Case Report: Preimplantation Genetic Testing and Pregnancy Outcomes in Women With Alport Syndrome
Case Report: Preimplantation Genetic Testing and Pregnancy Outcomes in Women With Alport Syndrome Open
Background Alport syndrome, a monogenic kidney disease, is characterized by progressive hemorrhagic nephritis, sensorineural hearing loss, and ocular abnormalities. Mutations in COL4A5 at Xq22 accounts for 80–85% of X-linked Alport syndrom…
View article: Abnormal Glucose Metabolism in Male Mice Offspring Conceived by in vitro Fertilization and Frozen-Thawed Embryo Transfer
Abnormal Glucose Metabolism in Male Mice Offspring Conceived by in vitro Fertilization and Frozen-Thawed Embryo Transfer Open
Frozen and thawed embryo transfer (FET) is currently widely applied in routine assisted reproductive technology (ART) procedure. It is of great necessity to assess the safety of FET and investigate the long-term effect including glucose me…
View article: Novel PGK1 determines SKP2-dependent AR stability and reprograms granular cell glucose metabolism facilitating ovulation dysfunction
Novel PGK1 determines SKP2-dependent AR stability and reprograms granular cell glucose metabolism facilitating ovulation dysfunction Open