Ninouk Akkerman
YOU?
Author Swipe
View article: Modeling host-microbe interactions in immunocompetent engineered human gut tissues
Modeling host-microbe interactions in immunocompetent engineered human gut tissues Open
The intestinal mucosal barrier contains microbial organisms within the lumen while preserving the ability to absorb nutrients. Dietary, microbial, and other exposures shaped human barrier evolution and continue to impact disease susceptibi…
View article: Lactate controls cancer stemness and plasticity through epigenetic regulation
Lactate controls cancer stemness and plasticity through epigenetic regulation Open
Tumors arise from uncontrolled cell proliferation driven by mutations in genes that regulate stem cell renewal and differentiation. Intestinal tumors, however, retain some hierarchical organization, maintaining both cancer stem cells (CSCs…
View article: Description and functional validation of human enteroendocrine cell sensors
Description and functional validation of human enteroendocrine cell sensors Open
Enteroendocrine cells (EECs) are gut epithelial cells that respond to intestinal contents by secreting hormones, including the incretins glucagon-like peptide 1 (GLP-1) and gastric inhibitory protein (GIP), which regulate multiple physiolo…
View article: Dawn of the organoid era
Dawn of the organoid era Open
Novel and updated approaches of culturing cells in 3D are rapidly advancing our understanding of development, health, and disease. As tissues have been found to behave more realistically in 3D than in 2D cultures, organoid technology in co…