Nipun U. Jayatissa
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View article: Downloadable Tool for Modeling of Salt, Urea and Water Transport in a Renal Tubule Segment: Application to the DCT
Downloadable Tool for Modeling of Salt, Urea and Water Transport in a Renal Tubule Segment: Application to the DCT Open
We have devised a user-friendly downloadable, standalone application that solves a set of ordinary differential equations describing steady-state mass balance for salt (NaCl), urea and water in a single renal tubule with axial flow. The mo…
View article: A brief history of the cortical thick ascending limb: a systems-biology perspective
A brief history of the cortical thick ascending limb: a systems-biology perspective Open
Here, we review key events in the accrual of knowledge about the cortical thick ascending limb (CTAL) of the kidney, starting with its initial characterization by Maurice Burg in 1973, and culminating with the application of systems biolog…
View article: Phosphoproteomic response to epidermal growth factor in native rat inner medullary collecting duct
Phosphoproteomic response to epidermal growth factor in native rat inner medullary collecting duct Open
EGF negatively regulates transepithelial water and salt transport across the kidney collecting duct. This study identified phosphoproteins affected by EGF stimulation in normal rat collecting ducts, providing insights into global cell sign…
View article: Bayesian mapping of protein kinases to vasopressin-regulated phosphorylation sites in renal collecting duct
Bayesian mapping of protein kinases to vasopressin-regulated phosphorylation sites in renal collecting duct Open
Vasopressin regulates water transport in the renal collecting duct in part through phosphorylation or dephosphorylation of proteins that regulate aquaporin-2. Prior studies have identified 51 vasopressin-regulated phosphorylation sites in …
View article: A resource database for protein kinase substrate sequence-preference motifs based on large-scale mass spectrometry data
A resource database for protein kinase substrate sequence-preference motifs based on large-scale mass spectrometry data Open
Background Protein phosphorylation is one of the most prevalent posttranslational modifications involved in molecular control of cellular processes, and is mediated by over 520 protein kinases in humans and other mammals. Identification of…