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View article: Unidirectional recruitment between MeCP2 and KSHV-encoded LANA revealed by CRISPR/Cas9 recruitment assay
Unidirectional recruitment between MeCP2 and KSHV-encoded LANA revealed by CRISPR/Cas9 recruitment assay Open
Kaposi’s sarcoma-associated herpesvirus (KSHV, HHV-8) is associated with several human malignancies. During latency, the viral genomes reside in the nucleus of infected cells as large non-integrated plasmids, known as episomes. To ensure e…
View article: Unidirectional protein recruitment is essential for viral latency
Unidirectional protein recruitment is essential for viral latency Open
Kaposi’s sarcoma associated herpesvirus (KSHV, HHV-8) is associated with several human malignancies. During latency the viral genomes reside in the nucleus of infected cells as large non-integrated plasmids, known as episomes. All KSHV inf…
View article: Abortive herpes simplex virus infection of nonneuronal cells results in quiescent viral genomes that can reactivate
Abortive herpes simplex virus infection of nonneuronal cells results in quiescent viral genomes that can reactivate Open
Significance Abortive viral infections are defined as cells that have been infected with a virus but did not produce any progeny virus as a result of the infection. Recent single-cell studies have shown that abortive infection is observed …
View article: Modulation of Cellular CpG DNA Methylation by Kaposi's Sarcoma-Associated Herpesvirus
Modulation of Cellular CpG DNA Methylation by Kaposi's Sarcoma-Associated Herpesvirus Open
In cancer cells, certain promoters become aberrantly methylated, contributing to the phenotype of the tumor. KSHV infection seems to modify cellular CpG methylation, but only a few methylated promoters have been identified in KSHV-infected…