Explanipedia

HER2 and HLA-A*02 dual CAR-T cells utilize LOH in a NOT logic gate to address on-target off-tumor toxicity Open

David Bassan, Leehee Weinberger, Jason Yi, Tanya Kim, Michael R. Weist , et al. · 2023

Background One of the major challenges in chimeric antigen receptor (CAR)-T cell therapy for solid tumors is the potential for on-target off-tumor toxicity due to the expression of CAR tumor antigens in essential tissues and organs. Here, …

Molecular Mechanisms in Murine Syngeneic Leukemia Stem Cells Open

Michael Chamo, Omri Koren, Oron Goldstein, Nir Bujanover, Nurit Keinan , et al. · 2023

Acute Myeloid Leukemia (AML) is a severe disease with a very high relapse rate. AML relapse may be attributable to leukemic stem cells (LSC). Notably, the “cancer stem cell” theory, which relates to LSCs, is controversial and criticized du…

<span>FLU‐LISA (</span>fluorescence‐linked immunosorbent assay<span>)</span>: high‐throughput antibody profiling using antigen microarrays Open

Shlomia Levy, Marwa Abd Alhadi, A. Azulay, Amit Kahana, Nir Bujanover , et al. · 2022

Vaccination and natural infection both elicit potent humoral responses that provide protection from subsequent infections. The immune history of an individual following such exposures is in part encoded by antibodies. While there are multi…

316 Next generation CAR-T incorporating an inhibitory CAR (iCAR) for increased safety in solid tumors Open

David Bassan, Michael R. Weist, Leehee Weinberger, Jason Yi, Gregor B. Adams , et al. · 2022

Background Chimeric antigen receptor (CAR)-T cell therapy has shown incredible clinical success for hematopoietic malignancies, but for solid tumors is limited by "on-target off-tumor" toxicity to vital organs due to lack of target specifi…

ELISA–on-Chip: High throughput antibody profiling using antigen microarrays Open

Shlomia Levy, Marwa Abd Alhadi, A. Azulay, Amit Kahana, Nir Bujanover , et al. · 2022

Vaccination and natural infection both elicit potent humoral responses that provide protection from subsequent infections. The immune-history of an individual following such exposures is in part encoded by antibodies. While there are multi…

Hypersensitivity response has negligible impact on Hematopoietic Stem Cells Open

Nir Bujanover, Roshina Thapa, Oron Goldstein, Leonid Olender, Omri Sharabi , et al. · 2021

Cyclosporine H Improves the Multi-Vector Lentiviral Transduction of Murine Haematopoietic Progenitors and Stem Cells Open

Leonid Olender, Nir Bujanover, Omri Sharabi, Oron Goldstein, Roi Gazit · 2020

Haematopoietic stem cells (HSCs) have the potential for lifetime production of blood and immune cells. The introduction of transgenes into HSCs is important for basic research, as well as for multiple clinical applications, because HSC tra…

Identification of immune-activated hematopoietic stem cells Open

Nir Bujanover, Oron Goldstein, Yariv Greenshpan, Hodaya Turgeman, Amit Klainberger , et al. · 2018

Mapping Whole-Transcriptome Splicing in Mouse Hematopoietic Stem Cells Open

Oron Goldstein, Karin Meyer, Yariv Greenshpan, Nir Bujanover, Mili Feigin , et al. · 2016

Hematopoietic stem cells (HSCs) are rare cells that generate all the various types of blood and immune cells. High-quality transcriptome data have enabled the identification of significant genes for HSCs. However, most genes are expressed …

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