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View article: Phototactic Decision-Making by Microalgae
Phototactic Decision-Making by Microalgae Open
We study how simple eukaryotic organisms make decisions in response to competing stimuli in the context of phototaxis by the unicellular alga . While negatively phototactic cells swim directly away from a collimated light beam, when presen…
View article: Integrated Ising model with global inhibition for decision-making
Integrated Ising model with global inhibition for decision-making Open
Humans and other organisms make decisions choosing between different options, with the aim of maximizing the reward and minimizing the cost. The main theoretical framework for modeling the decision-making process has been based on the high…
View article: Corrections in single-cell migration path in vivo are controlled by pulses in polar Rac1 activation
Corrections in single-cell migration path in vivo are controlled by pulses in polar Rac1 activation Open
Directed migration of single cells is central to a large number of processes in development and adult life. Corrections to the migration path of cells are often characterized by periodic loss of polarity that is followed by the generation …
View article: Phototactic Decision-Making by Micro-Algae
Phototactic Decision-Making by Micro-Algae Open
We study how simple eukaryotic organisms make decisions in response to competing stimuli in the context of phototaxis by the unicellular alga Chlamydomonas reinhardtii . While negatively phototactic cells swim directly away from a collimat…
View article: Maximal response to a mechanical leader at critical group size in ant collectives
Maximal response to a mechanical leader at critical group size in ant collectives Open
It is widely recognized that biological collectives operate near criticality to amplify their capability of collective response. The peak in susceptibility near criticality renders these groups highly responsive to external stimuli. While …
View article: Coupling Anisotropic Curvature and Nematic Order: Mechanisms of Membrane Shape Remodeling
Coupling Anisotropic Curvature and Nematic Order: Mechanisms of Membrane Shape Remodeling Open
This study theoretically investigates how anisotropic curved membrane components (CMCs) control vesicle morphology through curvature sensing, nematic alignment, topological defects, and volume constraints. By comparing arc-shaped and saddl…
View article: Confinement in fibrous environments positions and orients mitotic spindles
Confinement in fibrous environments positions and orients mitotic spindles Open
Accurate positioning of the mitotic spindle within the rounded cell body is critical to physiological maintenance. Mitotic cells encounter confinement from neighboring cells or the extracellular matrix (ECM), which can cause rotation of mi…
View article: Maximal response to a mechanical leader at critical group size in ant collectives
Maximal response to a mechanical leader at critical group size in ant collectives Open
It is widely recognized that biological collectives operate near criticality to amplify their capability of collective response. The peak in susceptibility near criticality renders these groups highly responsive to external stimuli. While …
View article: Chemotaxis-Driven Instabilities Govern Size, Shape and Migration Efficiency of Multicellular Clusters
Chemotaxis-Driven Instabilities Govern Size, Shape and Migration Efficiency of Multicellular Clusters Open
The collective chemotaxis of multicellular clusters is an important phenomenon in various physiological contexts, ranging from embryonic development to cancer metastasis. Such clusters often display interesting shape dynamics and instabili…
View article: Chemotaxis of branched cells in complex environments
Chemotaxis of branched cells in complex environments Open
Cell migration in vivo is often guided by chemical signals. Such chemotaxis, such as performed by immune cells migrating to a wound site, is complicated by the complex geometry inside living tissues. In this study, we extend our theoretica…
View article: Photometric decision making during the dawn choruses of cicadas
Photometric decision making during the dawn choruses of cicadas Open
We report a quantitative study of the onset of dawn choruses of cicadas in several natural habitats. A time-frequency analysis of the acoustical signals is used to define an order parameter for the development of collective singing. The en…
View article: Chemotaxis of branched cells in complex environments
Chemotaxis of branched cells in complex environments Open
Cell migration in vivo is often guided by chemical signals. Such chemotaxis, such as performed by immune cells migrating to a wound site, is complicated by the complex geometry inside living tissues. In this study, we extend our theoretica…
View article: Modeling how lamellipodia-driven cells maintain persistent migration and interact with external barriers
Modeling how lamellipodia-driven cells maintain persistent migration and interact with external barriers Open
Cell motility is fundamental to many biological processes, and cells exhibit a variety of migration patterns. Many motile cell types follow a universal law that connects their speed and persistency, a property that can originate from the i…
View article: Photometric Decision-Making During the Dawn Choruses of Cicadas
Photometric Decision-Making During the Dawn Choruses of Cicadas Open
We report the first quantitative study of the onset of dawn choruses of cicadas in several natural habitats. A time-frequency analysis of the acoustical signals is used to define an order parameter for the development of collective singing…
View article: Corrections in single cell migration path in vivo are controlled by pulses in polar Rac1 activation
Corrections in single cell migration path in vivo are controlled by pulses in polar Rac1 activation Open
Summary Directed migration of single cells is central to a large number of processes in development and adult life. Corrections to the migration path of cells are often characterized by periodic loss of polarity that is followed by the gen…
View article: Coupling anisotropic curvature and nematic order: mechanisms of membrane shape remodeling
Coupling anisotropic curvature and nematic order: mechanisms of membrane shape remodeling Open
This study theoretically investigates how anisotropic curved membrane components (CMCs) control vesicle morphology through curvature sensing, nematic alignment, topological defects and volume constraints.
View article: Comparing cooperative geometric puzzle solving in ants versus humans
Comparing cooperative geometric puzzle solving in ants versus humans Open
Biological ensembles use collective intelligence to tackle challenges together, but suboptimal coordination can undermine the effectiveness of group cognition. Testing whether collective cognition exceeds that of the individual is often im…
View article: Integrated Ising Model with global inhibition for decision making
Integrated Ising Model with global inhibition for decision making Open
Humans and other organisms make decisions choosing between different options, with the aim to maximize the reward and minimize the cost. The main theoretical framework for modeling the decision-making process has been based on the highly s…
View article: Integrated Ising Model with global inhibition for decision making
Integrated Ising Model with global inhibition for decision making Open
Humans and other organisms make decisions choosing between different options, with the aim to maximize the reward and minimize the cost. The main theoretical framework for modeling the decision-making process has been based on the highly s…
View article: Uncovering the Emergent Robustness and Treadmilling in a Cell-Mimicking Actin Cortex: Mechanistic insights from basic components
Uncovering the Emergent Robustness and Treadmilling in a Cell-Mimicking Actin Cortex: Mechanistic insights from basic components Open
Cell shape deformation in eukaryotes, is primarily determined by the actin cortex, a thin network of actin filaments and myosin motors. This network is attached to the plasma membrane endowing cells with their mechanical stability and stru…
View article: Modelling how lamellipodia-driven cells maintain persistent migration and interact with external barriers
Modelling how lamellipodia-driven cells maintain persistent migration and interact with external barriers Open
Cell motility is fundamental to many biological processes, and cells exhibit a variety of migration patterns. Many motile cell types follow a universal law that connects their speed and persistency, a property that can originate from the i…
View article: Confinement in fibrous environments positions and orients mitotic spindles
Confinement in fibrous environments positions and orients mitotic spindles Open
Accurate positioning of the mitotic spindle within the rounded cell body is critical to physiological maintenance. Adherent mitotic cells encounter confinement from neighboring cells or the extracellular matrix (ECM), which can cause rotat…
View article: Trade-off between branching and polarity controls decision-making during cell migration
Trade-off between branching and polarity controls decision-making during cell migration Open
Migrating cells often face microenvironmental constraints that force them to extend multiple, often highly dynamic, protrusions, that compete to choose the new direction. However, the analysis of how cells coordinate shape dynamics during …
View article: Shape dynamics and migration of branched cells on complex networks
Shape dynamics and migration of branched cells on complex networks Open
Migratory and tissue resident cells exhibit highly branched morphologies to perform their function and to adapt to the microenvironment. Immune cells, for example, display transient branched shapes while exploring the surrounding tissues. …
View article: A minimal physical model for curvotaxis driven by curved protein complexes at the cell’s leading edge
A minimal physical model for curvotaxis driven by curved protein complexes at the cell’s leading edge Open
Cells often migrate on curved surfaces inside the body, such as curved tissues, blood vessels, or highly curved protrusions of other cells. Recent in vitro experiments provide clear evidence that motile cells are affected by the curvature …
View article: How motility drives the glassy dynamics in confluent epithelial monolayers?
How motility drives the glassy dynamics in confluent epithelial monolayers? Open
As wounds heal, embryos develop, cancer spreads, or asthma progresses, the cellular monolayer undergoes glass transition between solid-like jammed and fluid-like flowing states. During some of these processes, the cells undergo an epitheli…
View article: Numerical studies of triangulated vesicles with anisotropic membrane inclusions
Numerical studies of triangulated vesicles with anisotropic membrane inclusions Open
In this study, we implement the deviatoric curvature model to examine dynamically triangulated surfaces with anisotropic membrane inclusions. The Monte-Carlo numerical scheme is devised to not only minimize the total bending energy of the …
View article: Geometrical Structure of Bifurcations during Spatial Decision-Making
Geometrical Structure of Bifurcations during Spatial Decision-Making Open
Animals must constantly make decisions on the move, such as when choosing among multiple options, or “targets,” in space. Recent evidence suggests that this results from a recursive feedback between the (vectorial) neural representation of…
View article: Models of Animal Behavior as Active Particle Systems with Nonreciprocal Interactions
Models of Animal Behavior as Active Particle Systems with Nonreciprocal Interactions Open
Active particle systems of interacting self-propelled particles offer a versatile framework for modeling complex systems. When employed to describe aspects of animal behavior, the complexity of animal movement and decision-making often req…
View article: Emergent seesaw oscillations during cellular directional decision-making
Emergent seesaw oscillations during cellular directional decision-making Open
Motile cells inside living tissues often encounter junctions, where their path branches into several alternative directions of migration. We present a theoretical model of cellular polarization for a cell migrating along a one-dimensional …