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View article: Long-term Hyperbaric Oxygen Treatment Enhances Nerve Regeneration and Remyelination in a Rat Sciatic Nerve Graft Model
Long-term Hyperbaric Oxygen Treatment Enhances Nerve Regeneration and Remyelination in a Rat Sciatic Nerve Graft Model Open
Background: Peripheral nerve injuries often lead to inconsistent outcomes due to the complexity of nerve regeneration. Hyperbaric oxygen therapy (HBOT) has been proposed to enhance regeneration by improving oxygenation, promoting angiogene…
View article: A Closed-system Technology for Mechanical Isolation of High Quantities of Stromal Vascular Fraction from Fat for Immediate Clinical Use
A Closed-system Technology for Mechanical Isolation of High Quantities of Stromal Vascular Fraction from Fat for Immediate Clinical Use Open
Background: Adipose tissue stromal vascular fraction (SVF) is increasingly used in the clinic. SVF separation from fat by enzymatic disruption is currently the gold standard for SVF isolation. However, enzymatic SVF isolation is time-consu…
View article: Supplementary Figure 8 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity
Supplementary Figure 8 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity Open
PDF file - 72K, Artificial tetraploidization of diploid MSCs
View article: Supplementary Figure 2 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity
Supplementary Figure 2 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity Open
PDF file - 329K, Gene expression analysis comparing diploid and tetraploid MSCs
View article: Supplementary Tables 2-3 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity
Supplementary Tables 2-3 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity Open
PDF file - 55K, Cytogenetic profile of cells used in the study and details of their tumorigenic properties
View article: Supplementary Figure 3 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity
Supplementary Figure 3 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity Open
PDF file - 162K, Gating of diploid and polyploid hepatocytes for sorting
View article: Supplementary Figure 8 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity
Supplementary Figure 8 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity Open
PDF file - 72K, Artificial tetraploidization of diploid MSCs
View article: Supplementary Figure 1 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity
Supplementary Figure 1 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity Open
PDF file - 205K, Spectral karyotype analysis of tumor cells originating from MSC injections
View article: Supplementary Legends for Figures 1-8, Tables 1-5 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity
Supplementary Legends for Figures 1-8, Tables 1-5 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity Open
PDF file - 89K
View article: Data from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity
Data from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity Open
Mesenchymal stromal cells (MSC) are used extensively in clinical trials; however, the possibility that MSCs have a potential for malignant transformation was raised. We examined the genomic stability versus the tumor-forming capacity of mu…
View article: Supplementary Figure 1 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity
Supplementary Figure 1 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity Open
PDF file - 205K, Spectral karyotype analysis of tumor cells originating from MSC injections
View article: Supplementary Legends for Figures 1-8, Tables 1-5 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity
Supplementary Legends for Figures 1-8, Tables 1-5 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity Open
PDF file - 89K
View article: Supplementary Tables 4-5 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity
Supplementary Tables 4-5 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity Open
PDF file - 38K, Lists of MSC populations and clones used in the study, their origin, ploidy and tumorigenic incidence
View article: Data from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity
Data from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity Open
Mesenchymal stromal cells (MSC) are used extensively in clinical trials; however, the possibility that MSCs have a potential for malignant transformation was raised. We examined the genomic stability versus the tumor-forming capacity of mu…
View article: Supplementary Table 1, Figures 4-7 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity
Supplementary Table 1, Figures 4-7 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity Open
PDF file - 176K, Supplementary figures describing the molecular analysis performed on 2N and 4N cells as well as on tumor derived cells. Includes a table listing the primers used in the study
View article: Supplementary Tables 4-5 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity
Supplementary Tables 4-5 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity Open
PDF file - 38K, Lists of MSC populations and clones used in the study, their origin, ploidy and tumorigenic incidence
View article: Supplementary Figure 3 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity
Supplementary Figure 3 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity Open
PDF file - 162K, Gating of diploid and polyploid hepatocytes for sorting
View article: Supplementary Table 1, Figures 4-7 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity
Supplementary Table 1, Figures 4-7 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity Open
PDF file - 176K, Supplementary figures describing the molecular analysis performed on 2N and 4N cells as well as on tumor derived cells. Includes a table listing the primers used in the study
View article: Supplementary Tables 2-3 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity
Supplementary Tables 2-3 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity Open
PDF file - 55K, Cytogenetic profile of cells used in the study and details of their tumorigenic properties
View article: Supplementary Figure 2 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity
Supplementary Figure 2 from Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity Open
PDF file - 329K, Gene expression analysis comparing diploid and tetraploid MSCs
View article: Comparing Efficacy of Common Pocket Irrigation Protocols in an Infected Breast Implant Model
Comparing Efficacy of Common Pocket Irrigation Protocols in an Infected Breast Implant Model Open
INTRODUCTION: Infection of breast implants is a leading cause for explantation. Contamination of implants may persist over time in the form of biofilm and is extremely difficult to eradicate. This has prompted the development of various pe…
View article: Cryopreservation of Stromal Vascular Fraction Cells Reduces Their Counts but Not Their Stem Cell Potency
Cryopreservation of Stromal Vascular Fraction Cells Reduces Their Counts but Not Their Stem Cell Potency Open
Background: Adipose-derived stem cells are derived from the nonfat component of adipose tissue termed the stromal vascular fraction (SVF). The use of freshly isolated autologous SVF cells as an alternative to adult stem cells is becoming m…
View article: Immunological and inflammatory mapping of vascularized composite allograft rejection processes in a rat model
Immunological and inflammatory mapping of vascularized composite allograft rejection processes in a rat model Open
High resemblance between the cues governing VCA and solid organ rejection was observed. Despite this high resemblance we describe also, for the first time, a damage induced inflammatory component in VCA rejection as immune cell infiltratio…
View article: Aging leads to impaired epicutaneous sensitization that causes attenuated allergy and pulmonary inflammation in mice
Aging leads to impaired epicutaneous sensitization that causes attenuated allergy and pulmonary inflammation in mice Open
Summary Aging is associated with altered decreased barrier function in the skin, which can lead to different types of immunoglobulin E (IgE)‐mediated sensitization to environmental allergens. Yet, allergen‐specific respiratory sensitizatio…
View article: Power-Assisted Liposuction Versus Tissue Resection for the Isolation of Adipose Tissue–Derived Mesenchymal Stem Cells: Phenotype, Senescence, and Multipotency at Advanced Passages
Power-Assisted Liposuction Versus Tissue Resection for the Isolation of Adipose Tissue–Derived Mesenchymal Stem Cells: Phenotype, Senescence, and Multipotency at Advanced Passages Open
Fat harvested by PAL or tissue resection yielded uniform cultures of ASCs with high division rates, low senescence ratios, and multipotency preserved into passages 3 and 4. Because PAL is less invasive, it may be preferable for the isolati…
View article: The tissue specific nature of mesenchymal stem/stromal cells: gaining better understanding for improved clinical outcomes
The tissue specific nature of mesenchymal stem/stromal cells: gaining better understanding for improved clinical outcomes Open
Mesenchymal stem/stromal cells (MSCs) are multipotent progenitors that are derived from most adult tissue as well as cord blood and placenta. MSCs are defined by their adherent nature, ability to propagate in culture and capacity to differ…