Niraj M. Desai
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View article: Five Years Follow-up of Imlifidase Desensitized Kidney Transplant Recipients
Five Years Follow-up of Imlifidase Desensitized Kidney Transplant Recipients Open
In four phase 2 clinical trials, patients underwent imlifidase-enabled kidney transplantation, converting a positive crossmatch (+XM) to negative. Here, we present data from 39 patients enrolled in the 5-year follow-up extension trial. Pat…
View article: Low prevalence of glomerulonephritis in transplanted kidneys from deceased donors with active hepatitis C virus infection
Low prevalence of glomerulonephritis in transplanted kidneys from deceased donors with active hepatitis C virus infection Open
The mean age was 40.3 versus 40.7 years for HCV-RNA+ versus HCV-negative donors, respectively. Expert pathology reviews showed that glomerular disease and isolated immune complex deposition were rare in both groups. The primary …
View article: Inflammation among kidney transplant donors with and without HIV: Multicenter HOPE in Action Consortium
Inflammation among kidney transplant donors with and without HIV: Multicenter HOPE in Action Consortium Open
View article: Outcomes of SOT Recipients With COVID-19 in Different Eras of COVID-19 Therapeutics
Outcomes of SOT Recipients With COVID-19 in Different Eras of COVID-19 Therapeutics Open
BACKGROUND: Few reports have focused on newer coronavirus disease 2019 (COVID-19) therapies (remdesivir, dexamethasone, and convalescent plasma) in solid organ transplant recipients; concerns had been raised regarding possible adverse impa…
View article: Long-term outcomes at 5 years posttransplant in imlifidase-desensitized kidney transplant patients
Long-term outcomes at 5 years posttransplant in imlifidase-desensitized kidney transplant patients Open
View article: Safety of Kidney Transplantation from Donors with HIV
Safety of Kidney Transplantation from Donors with HIV Open
The primary objective of this study is to determine if an HIV-infected deceased kidney donor (HIVD+) transplant is safe with regard to major transplant-related and HIV-related complications.
View article: Patient Perspectives on Solid Organ Transplantation From Donors With Hepatitis C Viremia to Recipients Without Hepatitis C Viremia
Patient Perspectives on Solid Organ Transplantation From Donors With Hepatitis C Viremia to Recipients Without Hepatitis C Viremia Open
Background Organ transplantation from donors with hepatitis C viremia (HCV) to recipients without HCV (HCV D+/R−) has excellent medical outcomes. Less is known about the psychosocial impact and experiences of HCV D+/R− recipients, particul…
View article: Wait Time Advantage for Transplant Candidates With HIV Who Accept Kidneys From Donors With HIV Under the HOPE Act
Wait Time Advantage for Transplant Candidates With HIV Who Accept Kidneys From Donors With HIV Under the HOPE Act Open
Background. Kidney transplant (KT) candidates with HIV face higher mortality on the waitlist compared with candidates without HIV. Because the HIV Organ Policy Equity (HOPE) Act has expanded the donor pool to allow donors with HIV (D + ), …
View article: Kidney Donation After Circulatory Death Using Thoracoabdominal Normothermic Regional Perfusion: The Largest Report of the United States Experience
Kidney Donation After Circulatory Death Using Thoracoabdominal Normothermic Regional Perfusion: The Largest Report of the United States Experience Open
Background. Thoracoabdominal normothermic regional perfusion (TA-NRP) has been increasingly used for donation after circulatory death (DCD) procurements in the United States. We present the largest report of outcomes of kidney transplants …
View article: Living kidney donors with HIV: experience and outcomes from a case series by the HOPE in Action Consortium
Living kidney donors with HIV: experience and outcomes from a case series by the HOPE in Action Consortium Open
National Institute of Allergy and Infectious Diseases, National Institutes of Health.
View article: Longer-Term Clinical Outcomes From the THINKER and EXPANDER Trials of Transplantation of HCV-RNA+ Donor Kidneys Into Hepatitis C Virus-Negative Recipients
Longer-Term Clinical Outcomes From the THINKER and EXPANDER Trials of Transplantation of HCV-RNA+ Donor Kidneys Into Hepatitis C Virus-Negative Recipients Open
View article: Association between primary graft function and 5-year outcomes of islet allogeneic transplantation in type 1 diabetes: a retrospective, multicentre, observational cohort study in 1210 patients from the Collaborative Islet Transplant Registry
Association between primary graft function and 5-year outcomes of islet allogeneic transplantation in type 1 diabetes: a retrospective, multicentre, observational cohort study in 1210 patients from the Collaborative Islet Transplant Registry Open
View article: Quality of reproductive health care provided by community health centers of a district located in western India- a mixed method study
Quality of reproductive health care provided by community health centers of a district located in western India- a mixed method study Open
Background: Under National Rural Health Mission in 2007, Indian Public Health Standards (IPHS) were introduced to strengthen health care services. As majority of health infrastructure is in existence before introduction of IPHS, there was …
View article: The effect of induction immunosuppression for kidney transplant on the latent HIV reservoir
The effect of induction immunosuppression for kidney transplant on the latent HIV reservoir Open
The HIV latent viral reservoir (LVR) remains a major challenge in the effort to find a cure for HIV. There is interest in lymphocyte-depleting agents, used in solid organ and bone marrow transplantation to reduce the LVR. This study evalua…
View article: Patient and Graft Survival After A1/A2-incompatible Living Donor Kidney Transplantation
Patient and Graft Survival After A1/A2-incompatible Living Donor Kidney Transplantation Open
Background. ABO type B and O kidney transplant candidates have increased difficulty identifying a compatible donor for living donor kidney transplantation (LDKT) and are harder to match in kidney paired donation registries. A2-incompatible…
View article: Successful kidney transplantation from a deceased donor with severe COVID-19 respiratory illness with undetectable SARS-CoV-2 in donor kidney and aorta
Successful kidney transplantation from a deceased donor with severe COVID-19 respiratory illness with undetectable SARS-CoV-2 in donor kidney and aorta Open
View article: One-Year Outcomes of the Multi-Center StudY to Transplant Hepatitis C-InfeCted kidneys (MYTHIC) Trial
One-Year Outcomes of the Multi-Center StudY to Transplant Hepatitis C-InfeCted kidneys (MYTHIC) Trial Open
The 1-year findings from this multicenter trial suggest that opting-in for HCV-viremic KT offers can increase probability of KT with excellent 1-year outcomes. Trial Registration: NCT03781726.
View article: National Landscape of Human Immunodeficiency Virus–Positive Deceased Organ Donors in the United States
National Landscape of Human Immunodeficiency Virus–Positive Deceased Organ Donors in the United States Open
Background Organ transplantation from donors with human immunodeficiency virus (HIV) to recipients with HIV (HIV D+/R+) presents risks of donor-derived infections. Understanding clinical, immunologic, and virologic characteristics of HIV-p…
View article: Kidney Transplantation Confers Survival Benefit for Candidates With Pulmonary Hypertension
Kidney Transplantation Confers Survival Benefit for Candidates With Pulmonary Hypertension Open
Background. Kidney transplantation (KT) is controversial in patients with pretransplant pulmonary hypertension (PtPH). We aimed to quantify post-KT graft and patient survival as well as survival benefit in recipients with PtPH. Methods. Us…
View article: Outcomes at 3 years posttransplant in imlifidase-desensitized kidney transplant patients
Outcomes at 3 years posttransplant in imlifidase-desensitized kidney transplant patients Open
View article: Similar Frequency and Inducibility of Intact Human Immunodeficiency Virus-1 Proviruses in Blood and Lymph Nodes
Similar Frequency and Inducibility of Intact Human Immunodeficiency Virus-1 Proviruses in Blood and Lymph Nodes Open
Background The human immunodeficiency virus (HIV)-1 latent reservoir (LR) in resting CD4+ T cells is a barrier to cure. LR measurements are commonly performed on blood samples and therefore may miss latently infected cells residing in tiss…
View article: Imlifidase Desensitization in Crossmatch-positive, Highly Sensitized Kidney Transplant Recipients: Results of an International Phase 2 Trial (Highdes)
Imlifidase Desensitization in Crossmatch-positive, Highly Sensitized Kidney Transplant Recipients: Results of an International Phase 2 Trial (Highdes) Open
Background. Highly HLA sensitized patients have limited access to life-saving kidney transplantation because of a paucity of immunologically suitable donors. Imlifidase is a cysteine protease that cleaves IgG leading to a rapid decrease in…
View article: Quantifying infection risks in incompatible living donor kidney transplant recipients
Quantifying infection risks in incompatible living donor kidney transplant recipients Open
Desensitization has enabled incompatible living donor kidney transplantation (ILDKT) across HLA/ABO barriers, but added immunomodulation might put patients at increased risk of infections. We studied 475 recipients from our center from 201…
View article: Four-Week Direct-Acting Antiviral Prophylaxis for Kidney Transplantation From Hepatitis C–Viremic Donors to Hepatitis C–Negative Recipients: An Open-Label Nonrandomized Study
Four-Week Direct-Acting Antiviral Prophylaxis for Kidney Transplantation From Hepatitis C–Viremic Donors to Hepatitis C–Negative Recipients: An Open-Label Nonrandomized Study Open
LettersJanuary 2021Four-Week Direct-Acting Antiviral Prophylaxis for Kidney Transplantation From Hepatitis C–Viremic Donors to Hepatitis C–Negative Recipients: An Open-Label Nonrandomized StudyChristine M. Durand, MD, Brittany Barnaba, MS,…
View article: Multicenter Study to Transplant Hepatitis C–Infected Kidneys (MYTHIC): An Open-Label Study of Combined Glecaprevir and Pibrentasvir to Treat Recipients of Transplanted Kidneys from Deceased Donors with Hepatitis C Virus Infection
Multicenter Study to Transplant Hepatitis C–Infected Kidneys (MYTHIC): An Open-Label Study of Combined Glecaprevir and Pibrentasvir to Treat Recipients of Transplanted Kidneys from Deceased Donors with Hepatitis C Virus Infection Open
Significance Statement Single-center trials and retrospective case series have reported promising outcomes transplanting kidneys from donors with hepatitis C virus (HCV) infection into HCV-negative recipients, although concerns remain abou…
View article: Outcomes of donor-derived superinfection screening in HIV-positive to HIV-positive kidney and liver transplantation: a multicentre, prospective, observational study
Outcomes of donor-derived superinfection screening in HIV-positive to HIV-positive kidney and liver transplantation: a multicentre, prospective, observational study Open
View article: A prospective multicenter pilot study of HIV-positive deceased donor to HIV-positive recipient kidney transplantation: HOPE in action
A prospective multicenter pilot study of HIV-positive deceased donor to HIV-positive recipient kidney transplantation: HOPE in action Open
View article: Survival benefit of accepting kidneys from older donation after cardiac death donors
Survival benefit of accepting kidneys from older donation after cardiac death donors Open
View article: Identifying scenarios of benefit or harm from kidney transplantation during the COVID-19 pandemic: A stochastic simulation and machine learning study
Identifying scenarios of benefit or harm from kidney transplantation during the COVID-19 pandemic: A stochastic simulation and machine learning study Open
Clinical decision-making in kidney transplant (KT) during the coronavirus disease 2019 (COVID-19) pandemic is understandably a conundrum: both candidates and recipients may face increased acquisition risks and case fatality rates (CFRs). G…
View article: Characterizing the landscape and impact of infections following kidney transplantation
Characterizing the landscape and impact of infections following kidney transplantation Open