Niraj Patel
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View article: Facilitated Subcutaneous Immunoglobulin 10% Safety Among Pediatric Patients With Primary Immunodeficiency Diseases
Facilitated Subcutaneous Immunoglobulin 10% Safety Among Pediatric Patients With Primary Immunodeficiency Diseases Open
Immunoglobulin replacement therapy is a fundamental treatment option to protect against infection for most patients with a primary deficiency in antibody production. Facilitated subcutaneous immunoglobulin (fSCIG) 10% is an immunoglobulin …
View article: Allogeneic hematopoietic stem cell transplantation for STAT3 hyper-IgE syndrome: a worldwide study
Allogeneic hematopoietic stem cell transplantation for STAT3 hyper-IgE syndrome: a worldwide study Open
Signal transduction and activator of transcription 3 hyperimmunoglobulin E syndrome (STAT3-HIES) is a multisystem disorder causing recurrent skin and respiratory infection with bronchiectasis, pneumatoceles, and aspergillosis; lymphoma; an…
View article: Personalized Dietary Impact Assessment Using Advanced Statistical Modeling
Personalized Dietary Impact Assessment Using Advanced Statistical Modeling Open
Precision nutrition relies on understanding how individuals uniquely respond to dietary interventions. This study utilizes a robust N-of-1 trial design involving 80 participants to investigate postprandial glycemic responses to two distinc…
View article: Development and Implementation: The Registry for Autoimmunity and Infections in Female Carriers of Chronic Granulomatous Disease: Surveillance and Evaluation (RAISE) Study
Development and Implementation: The Registry for Autoimmunity and Infections in Female Carriers of Chronic Granulomatous Disease: Surveillance and Evaluation (RAISE) Study Open
Background X-linked chronic granulomatous disease (XLCGD) is a rare inborn error of immunity (IEI) associated with infections, inflammation, and autoimmunity. Female carriers of XLCGD experience similar symptoms due to skewed X-chromosome …
View article: Analysis of rare genetic variants in All of Us cohort patients with common variable immunodeficiency
Analysis of rare genetic variants in All of Us cohort patients with common variable immunodeficiency Open
Common variable immunodeficiency (CVID) is a group of genetic disorders involving more than a dozen genetic loci and characterized by a deficiency in specific antibody isotypes leading to poor immune responses and recurrent infection. CVID…
View article: Long-Term Safety of Facilitated Subcutaneous Immunoglobulin 10% Treatment in US Clinical Practice in Patients with Primary Immunodeficiency Diseases: Results from a Post-Authorization Safety Study
Long-Term Safety of Facilitated Subcutaneous Immunoglobulin 10% Treatment in US Clinical Practice in Patients with Primary Immunodeficiency Diseases: Results from a Post-Authorization Safety Study Open
Facilitated subcutaneous immunoglobulin (fSCIG) 10% is an immunoglobulin replacement therapy that utilizes recombinant human hyaluronidase (rHuPH20) to enhance immunoglobulin dispersion and absorption, allowing for longer treatment interva…
View article: Comparative Analysis of Deep Learning Models for Accurate Detection of Plant Diseases: A Comprehensive Survey
Comparative Analysis of Deep Learning Models for Accurate Detection of Plant Diseases: A Comprehensive Survey Open
Agriculture plays an important role towards the economic growth of any nation. It also has a significant effect on global GDP. The enhancement in agro production helps in controlling greatly the inflation. Today a large percentage of popul…
View article: A robust and reliable methodology to perform GECI-based multi-time point neuronal calcium imaging within mixed cultures of human iPSC-derived cortical neurons
A robust and reliable methodology to perform GECI-based multi-time point neuronal calcium imaging within mixed cultures of human iPSC-derived cortical neurons Open
Introduction Human induced pluripotent stem cells (iPSCs), with their ability to generate human neural cells (astrocytes and neurons) from patients, hold great promise for understanding the pathophysiology of major neuropsychiatric disease…
View article: Safety and Efficacy of Hizentra® Following Pediatric Hematopoietic Cell Transplant for Treatment of Primary Immunodeficiencies
Safety and Efficacy of Hizentra® Following Pediatric Hematopoietic Cell Transplant for Treatment of Primary Immunodeficiencies Open
Primary immunodeficiency disease (PIDD) comprises a group of disorders of immune function. Some of the most severe PIDD can be treated with hematopoietic cell transplant (HCT). Hizentra® is a 20% liquid IgG product approved for subcutaneou…
View article: Safety and Efficacy of Hizentra ® Following Pediatric Hematopoietic Cell Transplant for Treatment of Primary Immunodeficiencies
Safety and Efficacy of Hizentra ® Following Pediatric Hematopoietic Cell Transplant for Treatment of Primary Immunodeficiencies Open
Primary Immunodeficiency disease (PIDD) comprise a group of disorders of immune function. Some of the most severe PIDD can be treated with hematopoietic cell transplant (HCT). Hizentra® is a 20% liquid IgG product approved for subcutaneous…
View article: Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome
Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome Open
STAT3 GOF patients present with a wide array of immune-mediated disease including lymphoproliferation, autoimmune cytopenias, and multisystem autoimmunity. Patient care tends to be siloed, without a clear treatment strategy. Thus, early id…
View article: Synthesis, Self-Aggregation, Surface Characteristics, Electrochemical Property, Micelle Size, and Antimicrobial Activity of a Halogen-Free Picoline-Based Surface-Active Ionic Liquid
Synthesis, Self-Aggregation, Surface Characteristics, Electrochemical Property, Micelle Size, and Antimicrobial Activity of a Halogen-Free Picoline-Based Surface-Active Ionic Liquid Open
We present a new approach toward the design of a halogen-free picoline-based surface-active ionic liquid (SAIL) (1-octyl-4-methyl pyridinium dodecyl sulfate) [C8γPic]DS consisting of long dodecyl sulfate (DS) as an anion. The surface prope…
View article: RAVIR: A Dataset and Methodology for the Semantic Segmentation and Quantitative Analysis of Retinal Arteries and Veins in Infrared Reflectance Imaging
RAVIR: A Dataset and Methodology for the Semantic Segmentation and Quantitative Analysis of Retinal Arteries and Veins in Infrared Reflectance Imaging Open
The retinal vasculature provides important clues in the diagnosis and monitoring of systemic diseases including hypertension and diabetes. The microvascular system is of primary involvement in such conditions, and the retina is the only an…
View article: 1127. Validation of an Adult and Pediatric Beta-Lactam Allergy Risk Stratification Tool
1127. Validation of an Adult and Pediatric Beta-Lactam Allergy Risk Stratification Tool Open
Background Penicillin allergies are commonly reported, yet more than 95% of these patients can tolerate β-lactams. A comprehensive allergy history is essential when determining which patients can safely receive a β-lactam but is rarely obt…
View article: High risk of relapsed disease in patients with NK/T-cell chronic active Epstein-Barr virus disease outside of Asia
High risk of relapsed disease in patients with NK/T-cell chronic active Epstein-Barr virus disease outside of Asia Open
Chronic active Epstein-Barr virus (EBV) disease (CAEBV) is characterized by high levels of EBV predominantly in T and/or natural killer cells with lymphoproliferation, organ failure due to infiltration of tissues with virus-infected cells,…
View article: Screening Electrocardiogram in Young Athletes and Military Members: A Systematic Review and Meta-Analysis
Screening Electrocardiogram in Young Athletes and Military Members: A Systematic Review and Meta-Analysis Open
Objective To determine the effect of electrocardiogram (ECG) screening on the prevention of sudden cardiac arrest and death in young athletes and military members. Data Sources MEDLINE, Embase, CENTRAL, Web of Science, BIOSIS, Scopus, SPOR…
View article: Incidence of Sudden Cardiac Arrest and Death in Young Athletes and Military Members: A Systematic Review and Meta-Analysis
Incidence of Sudden Cardiac Arrest and Death in Young Athletes and Military Members: A Systematic Review and Meta-Analysis Open
Objective To evaluate the quality of the evidence on the incidence of sudden cardiac arrest (SCA) and sudden cardiac death (SCD) in athletes and military members and estimate the annual incidence of SCA and SCD. Data Sources We searched ME…
View article: Safety and Tolerability of Subcutaneous IgPro20 at High Infusion Parameters in Patients with Primary Immunodeficiency: Findings from the Pump-Assisted Administration Cohorts of the HILO Study
Safety and Tolerability of Subcutaneous IgPro20 at High Infusion Parameters in Patients with Primary Immunodeficiency: Findings from the Pump-Assisted Administration Cohorts of the HILO Study Open
Purpose To evaluate the safety and tolerability of subcutaneous IgPro20 (Hizentra ® , CSL Behring, King of Prussia, PA, USA) administered at high infusion parameters (> 25 mL and > 25 mL/h per injection site) in patients with primary immun…
View article: Next generation business models for higher education: The pandemic push
Next generation business models for higher education: The pandemic push Open
The higher education enterprise faces increasing strategic, demographic, commoditization, and technological threats in the context of a declining birthrate and rising costs. Yet, the ability of nations to keep raising their standard of liv…
View article: Comparison of Pneumococcal Avidity and Antibody Concentration in Children with Recurrent Infections: A Retrospective Pilot Study
Comparison of Pneumococcal Avidity and Antibody Concentration in Children with Recurrent Infections: A Retrospective Pilot Study Open
Measurement of pneumococcal antibody concentration is a frequently used parameter for functional antibody response to vaccination. Antibody concentration in response to vaccination and strength of antigen-antibody (avidity) interaction are…
View article: Is Rotavirus Immunization Safe in Infants Born to Mothers Treated with Immunosuppressive Drugs for Inflammatory Bowel Disease During Pregnancy?
Is Rotavirus Immunization Safe in Infants Born to Mothers Treated with Immunosuppressive Drugs for Inflammatory Bowel Disease During Pregnancy? Open
The licensed rotavirus vaccines are live attenuated and are a component of the routine U.S. childhood immunization schedule. Live vaccines administered to infants of mothers who received biologic response modifiers (BRM) during pregnancy c…
View article: Screening electrocardiogram in young athletes and military members: a systematic review and meta-analysis
Screening electrocardiogram in young athletes and military members: a systematic review and meta-analysis Open
Objective To determine the effect of electrocardiogram (ECG) screening on prevention of sudden cardiac arrest and death (SCA/D) in young athletes and military members. Design Systematic review and meta-analysis Data Sources MEDLINE, Embase…