Nirajan Shrestha
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View article: Novel metabolic role of the complement activator MASP-2 in regulating pancreatic β-cell function
Novel metabolic role of the complement activator MASP-2 in regulating pancreatic β-cell function Open
View article: Editorial: Lipid metabolism in metabolic dysfunction- associated steatotic liver disease
Editorial: Lipid metabolism in metabolic dysfunction- associated steatotic liver disease Open
View article: Sex-Specific Changes to Brain Fatty Acids, Plasmalogen, and Plasma Endocannabinoids in Offspring Exposed to Maternal and Postnatal High-Linoleic-Acid Diets
Sex-Specific Changes to Brain Fatty Acids, Plasmalogen, and Plasma Endocannabinoids in Offspring Exposed to Maternal and Postnatal High-Linoleic-Acid Diets Open
Linoleic acid (LA) is required for neuronal development. We have previously demonstrated sex-specific changes in cardiovascular and hepatic function in rat offspring from mothers consuming a high-LA diet, with some effects associated with …
View article: Maternal Diet High in Linoleic Acid Alters Renal Branching Morphogenesis and mTOR/AKT Signalling Genes in Rat Fetal Kidneys
Maternal Diet High in Linoleic Acid Alters Renal Branching Morphogenesis and mTOR/AKT Signalling Genes in Rat Fetal Kidneys Open
Linoleic acid (LA), an n-6 polyunsaturated fatty acid (PUFA), is obtained from the maternal diet during pregnancy, and is essential for normal fetal growth and development. A maternal high-LA (HLA) diet alters maternal and offspring fatty …
View article: Maternal Diet High in Linoleic Acid Alters Offspring Lipids and Hepatic Regulators of Lipid Metabolism in an Adolescent Rat Model
Maternal Diet High in Linoleic Acid Alters Offspring Lipids and Hepatic Regulators of Lipid Metabolism in an Adolescent Rat Model Open
Linoleic acid (LA), an n-6 polyunsaturated fatty acid (PUFA), is essential for fetal growth and development. A maternal high LA (HLA) diet alters cardiovascular development in adolescent rats and hepatic function in adult rats in a sex-spe…
View article: ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits
ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits Open
View article: A genetically encoded tool to increase cellular NADH/NAD+ ratio in living cells
A genetically encoded tool to increase cellular NADH/NAD+ ratio in living cells Open
View article: Inflammatory myofibroblastic tumor presenting as ileocolic intussusception: A case report
Inflammatory myofibroblastic tumor presenting as ileocolic intussusception: A case report Open
Key Clinical Message The report urges considering rare neoplastic tumor, like IMT, in intussusception cases and underscores the vital role of comprehensive and swift diagnosis in influencing treatment choices and patient results. Abstract …
View article: Changes in Essential Fatty Acids and Ileal Genes Associated with Metabolizing Enzymes and Fatty Acid Transporters in Rodent Models of Cystic Fibrosis
Changes in Essential Fatty Acids and Ileal Genes Associated with Metabolizing Enzymes and Fatty Acid Transporters in Rodent Models of Cystic Fibrosis Open
Cystic fibrosis (CF), the result of mutations in the CF transmembrane conductance regulator (CFTR), causes essential fatty acid deficiency. The aim of this study was to characterize fatty acid handling in two rodent models of CF; one strai…
View article: Essential Fatty Acid Deficiency in Cystic Fibrosis Disease Progression: Role of Genotype and Sex
Essential Fatty Acid Deficiency in Cystic Fibrosis Disease Progression: Role of Genotype and Sex Open
Adequate intake of nutrients such as essential fatty acids (EFA) are critical in cystic fibrosis (CF). The clinical course of deterioration of lung function in people with CF has been shown to relate to nutrition. Independent of the higher…
View article: Role for animal models in understanding essential fatty acid deficiency in cystic fibrosis
Role for animal models in understanding essential fatty acid deficiency in cystic fibrosis Open
View article: Sex-Specific Differences in Lysine, 3-Hydroxybutyric Acid and Acetic Acid in Offspring Exposed to Maternal and Postnatal High Linoleic Acid Diet, Independent of Diet
Sex-Specific Differences in Lysine, 3-Hydroxybutyric Acid and Acetic Acid in Offspring Exposed to Maternal and Postnatal High Linoleic Acid Diet, Independent of Diet Open
Background: Linoleic acid (LA) is an essential polyunsaturated fatty acid (PUFA) that is required for foetal growth and development. Excess intake of LA can be detrimental for metabolic health due to its pro-inflammatory properties; howeve…
View article: Maternal and postnatal diet high in linoleic acid alters fatty acid composition, cholesterol and hepatic gene expression, in adult offspring in a sex‐specific manner
Maternal and postnatal diet high in linoleic acid alters fatty acid composition, cholesterol and hepatic gene expression, in adult offspring in a sex‐specific manner Open
Linoleic acid (LA), an n‐6 polyunsaturated fatty acid (PUFA), is essential for fetal growth and development. The consumption of LA has increased over the last decades due to availability in foods. In this study, we aimed to investigate the…
View article: Maternal diet high in linoleic acid alters offspring fatty acids and cardiovascular function in a rat model
Maternal diet high in linoleic acid alters offspring fatty acids and cardiovascular function in a rat model Open
Linoleic acid (LA), an essential n -6 fatty acid (FA), is critical for fetal development. We investigated the effects of maternal high LA (HLA) diet on offspring cardiac development and its relationship to circulating FA and cardiovascular…
View article: Maternal and Postnatal High Linoleic Acid Diet Impacts Lipid Metabolism in Adult Rat Offspring in a Sex-Specific Manner
Maternal and Postnatal High Linoleic Acid Diet Impacts Lipid Metabolism in Adult Rat Offspring in a Sex-Specific Manner Open
Linoleic acid (LA), an n-6 polyunsaturated fatty acid (PUFA), is essential for fetal growth and development. We aimed to investigate the effect of maternal and postnatal high LA (HLA) diet on plasma FA composition, plasma and hepatic lipid…
View article: Role of High Maternal Linoleic Acid on Offspring Health
Role of High Maternal Linoleic Acid on Offspring Health Open
Maternal nutrition during pregnancy plays a critical role in the adult-onset of disease in a mother’s children. The first 1000 days, spanning from conception to two years of life, are an important period when appropriate nutritional needs …
View article: Mitochondrial Function, Fatty Acid Metabolism, and Body Composition in the Hyperbilirubinemic Gunn Rat
Mitochondrial Function, Fatty Acid Metabolism, and Body Composition in the Hyperbilirubinemic Gunn Rat Open
Background: Circulating bilirubin is associated with reduced adiposity in human and animal studies. A possible explanation is provided by in vitro data that demonstrates that bilirubin inhibits mitochondrial function and decreases efficien…
View article: Unusual presentation of metastatic malignant melanoma: a case report
Unusual presentation of metastatic malignant melanoma: a case report Open
Introduction: The presentation of metastatic lesion of malignant melanoma (MM) may be unusual, as this case, in which the lesions were multicystic swelling over right arm and necrotized swelling at right chest wall. Identifying the unusual…
View article: Developmental programming of peripheral diseases in offspring exposed to maternal obesity during pregnancy
Developmental programming of peripheral diseases in offspring exposed to maternal obesity during pregnancy Open
Obesity is an increasing global health epidemic that affects all ages, including women of reproductive age. During pregnancy, maternal obesity is associated with adverse pregnancy outcomes that lead to complications for the mother. In addi…
View article: Role for endocannabinoids in early pregnancy: recent advances and the effects of cannabis use
Role for endocannabinoids in early pregnancy: recent advances and the effects of cannabis use Open
The endocannabinoid system (ECS) is associated with several physiological processes, including reproduction. This system consists of the cannabinoid receptors, endocannabinoid ligands, and enzymes that metabolize and degrade these fatty ac…
View article: Maternal High Linoleic Acid Alters Placental Fatty Acid Composition
Maternal High Linoleic Acid Alters Placental Fatty Acid Composition Open
Fetal development is modulated by maternal nutrition during pregnancy. The dietary intake of linoleic acid (LA), an essential dietary n-6 polyunsaturated fatty acid (PUFA), has increased. We previously published that increased LA consumpti…
View article: Role of a Maternal Diet High in Linoleic Acid on the Plasma Fatty Acid Composition in Rat Offspring
Role of a Maternal Diet High in Linoleic Acid on the Plasma Fatty Acid Composition in Rat Offspring Open
Linoleic acid (LA) is a major omega‐6 polyunsaturated fatty acid (PUFA) which is essential in our diet. LA is an important fatty acid for fetal growth and development and is transported from mother to fetus through the placenta. Dietary in…
View article: Elevated maternal linoleic acid alters placental fatty acids, nutrient transporters and inflammatory proteins
Elevated maternal linoleic acid alters placental fatty acids, nutrient transporters and inflammatory proteins Open
Linoleic acid (LA) is the major omega‐6 fatty acid which is obtained from our diet. During pregnancy, LA is required for adequate fetal growth and development. For the growing fetus LA can only be obtained from the maternal diet, and is tr…
View article: Role of omega‐6 and omega‐3 fatty acids in fetal programming
Role of omega‐6 and omega‐3 fatty acids in fetal programming Open
Maternal nutrition plays a critical role in fetal development and can influence adult onset of disease. Linoleic acid (LA) and alpha‐linolenic acid (ALA) are major omega‐6 (n‐6) and n‐3 polyunsaturated fatty acids (PUFA), respectively, tha…
View article: Pregnancy and diet-related changes in the maternal gut microbiota following exposure to an elevated linoleic acid diet
Pregnancy and diet-related changes in the maternal gut microbiota following exposure to an elevated linoleic acid diet Open
Dietary intakes of linoleic acid (LA) have increased, including in women of reproductive age. Changes in maternal gut microbiome have been implicated in the metabolic adaptions that occur during pregnancy. We aimed to investigate whether c…
View article: The effect of high maternal linoleic acid on endocannabinoid signalling in rodent hearts
The effect of high maternal linoleic acid on endocannabinoid signalling in rodent hearts Open
The endocannabinoid system (ECS), modulated by metabolites of linoleic acid (LA), is important in regulating cardiovascular function. In pregnancy, LA is vital for foetal development. We investigated the effects of elevated LA in H9c2 card…
View article: Elevated maternal linoleic acid reduces circulating leptin concentrations, cholesterol levels and male fetal survival in a rat model
Elevated maternal linoleic acid reduces circulating leptin concentrations, cholesterol levels and male fetal survival in a rat model Open
Key points Linoleic acid consumption is increasing in Western populations. We investigated whether elevated linoleic acid in pregnancy was deleterious to mothers or offspring. Maternal and fetal body and organ weights were not affected by …
View article: Linoleic Acid Increases Prostaglandin E2 Release and Reduces Mitochondrial Respiration and Cell Viability in Human Trophoblast-Like Cells
Linoleic Acid Increases Prostaglandin E2 Release and Reduces Mitochondrial Respiration and Cell Viability in Human Trophoblast-Like Cells Open
Exposure to LA decreases cell viability, alters mRNA expression of FA transport related proteins, mitochondrial respiration and function, and inflammatory responses in trophoblasts. These findings may have implications on placental functio…
View article: The fate of hepatocyte cell line derived from a liver injury model with long-term in vitro passage
The fate of hepatocyte cell line derived from a liver injury model with long-term in vitro passage Open
View article: Peripheral modulation of the endocannabinoid system in metabolic disease
Peripheral modulation of the endocannabinoid system in metabolic disease Open