Nirakar Sahoo
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View article: Ubiquitination of Oncogenic Mutant p53 via Attenuation of Ribosome Biogenesis Machinery Effectively Inhibits Pancreatic Tumor Growth
Ubiquitination of Oncogenic Mutant p53 via Attenuation of Ribosome Biogenesis Machinery Effectively Inhibits Pancreatic Tumor Growth Open
Dysregulated ribosome biogenesis and p53 mutations are known to play oncogenic roles in various cancers, including pancreatic cancer. In this study, we demonstrated the therapeutic potential of BMH-21, a pharmacologic inhibitor of RNA poly…
View article: IFIT3 activation significantly contributes to HIV-1-associated neurodegenerative disorder-mediated neuroinflammation
IFIT3 activation significantly contributes to HIV-1-associated neurodegenerative disorder-mediated neuroinflammation Open
Introduction The advent of effective combination antiretroviral therapy (cART) has significantly improved HIV-1 treatment, saving millions of lives. However, HAND remains a concern, particularly among aging individuals with HIV-1. The mech…
View article: Multiscale Materials Engineering via Self‐Assembly of Pentapeptide Derivatives from SARS CoV E Protein
Multiscale Materials Engineering via Self‐Assembly of Pentapeptide Derivatives from SARS CoV E Protein Open
Short peptide‐based supramolecular hydrogels hold enormous potential for a wide range of applications. However, the gelation of these systems is very challenging to control. Minor changes in the peptide sequence can significantly influence…
View article: IFIT3 GENE EXPRESSION AND FUNCTION CONTRIBUTE TO HAND PATHOLOGY EVEN WITH ANTIRETROVIRAL THERAPIES (CARTS)
IFIT3 GENE EXPRESSION AND FUNCTION CONTRIBUTE TO HAND PATHOLOGY EVEN WITH ANTIRETROVIRAL THERAPIES (CARTS) Open
The advent of cART has revolutionized the management of HIV-1 infection and saved the lives of millions of people worldwide. Yet, HIV-Associated Neurocognitive Disorder (HAND) continues to be clinically relevant with aging people with HIV-…
View article: Analysis of Sanitizer Rotation on the Susceptibility, Biofilm Forming Ability and Caco-2 Cell Adhesion and Invasion of Listeria
Analysis of Sanitizer Rotation on the Susceptibility, Biofilm Forming Ability and Caco-2 Cell Adhesion and Invasion of Listeria Open
The purpose of this study was to determine the effect of sanitizer use conditions on the susceptibility, biofilm forming ability and pathogenicity of Listeria monocytogenes. Two different strains of L. monocytogenes and a non-pathogenic L.…
View article: Mechanistic insight into functionally different human islet polypeptide (hIAPP) amyloid: the intrinsic role of the C-terminal structural motifs
Mechanistic insight into functionally different human islet polypeptide (hIAPP) amyloid: the intrinsic role of the C-terminal structural motifs Open
Targeting amyloidosis requires high-resolution insight into the underlying mechanisms of amyloid aggregation.
View article: Scalar Dark Matter and Radiative Dirac neutrino mass in an extended $U(1)_{B-L}$ model
Scalar Dark Matter and Radiative Dirac neutrino mass in an extended $U(1)_{B-L}$ model Open
We explore a gauged $U(1)_{B-L}$ extension of standard model with inclusion of three right-handed neutrinos of exotic $B-L$ charges to cancel the gauge anomaly. Non-trivial transformation of new particles under $B-L$ symmetry forbids the n…
View article: A Sugarcane G-Protein-Coupled Receptor, ShGPCR1, Confers Tolerance to Multiple Abiotic Stresses
A Sugarcane G-Protein-Coupled Receptor, ShGPCR1, Confers Tolerance to Multiple Abiotic Stresses Open
Sugarcane ( Saccharum spp.) is a prominent source of sugar and serves as bioenergy/biomass feedstock globally. Multiple biotic and abiotic stresses, including drought, salinity, and cold, adversely affect sugarcane yield. G-protein-coupled…
View article: Deciphering the Role of Ion Channels in Early Defense Signaling against Herbivorous Insects
Deciphering the Role of Ion Channels in Early Defense Signaling against Herbivorous Insects Open
Plants and insect herbivores are in a relentless battle to outwit each other. Plants have evolved various strategies to detect herbivores and mount an effective defense system against them. These defenses include physical and structural ba…
View article: Tobacco Hornworm (Manduca sexta) Oral Secretion Elicits Reactive Oxygen Species in Isolated Tomato Protoplasts
Tobacco Hornworm (Manduca sexta) Oral Secretion Elicits Reactive Oxygen Species in Isolated Tomato Protoplasts Open
Plants are under constant attack by a suite of insect herbivores. Over millions of years of coexistence, plants have evolved the ability to sense insect feeding via herbivore-associated elicitors in oral secretions, which can mobilize defe…
View article: LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses
LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses Open
Significance Cells encountering physiological stresses often become vacuolated, but the source of the vacuoles and their role in causing or ameliorating necrotic cell death are unclear. Studies of cells responding to hypoosmotic, hypoxic, …
View article: Small-molecule activation of lysosomal TRP channels ameliorates Duchenne muscular dystrophy in mouse models
Small-molecule activation of lysosomal TRP channels ameliorates Duchenne muscular dystrophy in mouse models Open
A lysosome activator ameliorates muscular dystrophies.
View article: Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR
Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR Open
Rapamycin (Rap) and its derivatives, called rapalogs, are being explored in clinical trials targeting cancer and neurodegeneration. The underlying mechanisms of Rap actions, however, are not well understood. Mechanistic target of rapamycin…
View article: Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse
Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse Open
The enteric nervous system (ENS) consists of neurons and enteric glial cells (EGCs) that reside within the smooth muscle wall, submucosa and lamina propria. EGCs play important roles in gut homeostasis through the release of various trophi…
View article: A voltage-dependent K+ channel in the lysosome is required for refilling lysosomal Ca2+ stores
A voltage-dependent K+ channel in the lysosome is required for refilling lysosomal Ca2+ stores Open
The resting membrane potential (Δψ) of the cell is negative on the cytosolic side and determined primarily by the plasma membrane’s selective permeability to K+. We show that lysosomal Δψ is set by lysosomal membrane permeabilities to Na+ …