Niranjan Thomas
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View article: Letter in response to the article: “Therapeutic hypothermia for neonatal encephalopathy in developing countries: Current evidence”
Letter in response to the article: “Therapeutic hypothermia for neonatal encephalopathy in developing countries: Current evidence” Open
We read with interest the paper "Therapeutic hypothermia for neonatal encephalopathy in developing countries: Current evidence" by Deepak Chawla.1Chawla D. Therapeutic hypothermia for neonatal encephalopathy in developing countries: curren…
View article: Biochemical profiles and organ dysfunction in neonates with hypoxic-ischemic encephalopathy post-hoc analysis of the THIN trial
Biochemical profiles and organ dysfunction in neonates with hypoxic-ischemic encephalopathy post-hoc analysis of the THIN trial Open
View article: Early-onset neonatal seizures: lidocaine toxicity as a rare differential diagnosis to hypoxic ischaemic encephalopathy
Early-onset neonatal seizures: lidocaine toxicity as a rare differential diagnosis to hypoxic ischaemic encephalopathy Open
A term newborn girl presented with apnoea and seizures at approximately 20 min of life following an uneventful vaginal delivery. She required admission to the Neonatal Intensive Care Unit following intubation and was commenced on conventio…
View article: Improving Cohort-Hospital Matching Accuracy through Standardization and Validation of Participant Identifiable Information
Improving Cohort-Hospital Matching Accuracy through Standardization and Validation of Participant Identifiable Information Open
Linking very large, consented birth cohorts to birthing hospitals clinical data could elucidate the lifecourse outcomes of health care and exposures during the pregnancy, birth and newborn periods. Unfortunately, cohort personally identifi…
View article: Development and Validation of a Deep Learning Method to Predict Cerebral Palsy From Spontaneous Movements in Infants at High Risk
Development and Validation of a Deep Learning Method to Predict Cerebral Palsy From Spontaneous Movements in Infants at High Risk Open
In this prognostic study, a deep learning-based method for predicting CP at 9 to 18 weeks' corrected age had predictive accuracy on external validation, which suggests possible avenues for using deep learning-based software to provide obje…
View article: Questions about the HELIX trial
Questions about the HELIX trial Open
We congratulate Sudhin Thayyil and colleagues1Thayyil S Pant S Montaldo P et al.Hypothermia for moderate or severe neonatal encephalopathy in low-income and middle-income countries (HELIX): a randomised controlled trial in India, Sri Lanka…
View article: Placental chorioangioma: an unusual cause of neonatal cardiomyopathy
Placental chorioangioma: an unusual cause of neonatal cardiomyopathy Open
A late preterm baby presented with clinical and echocardiographic features of cardiomyopathy and cardiac failure soon after birth. After extensive metabolic, infective and genetic investigations, the likely cause was established to be due …
View article: Prediction of outcome from MRI and general movements assessment after hypoxic-ischaemic encephalopathy in low-income and middle-income countries: data from a randomised controlled trial
Prediction of outcome from MRI and general movements assessment after hypoxic-ischaemic encephalopathy in low-income and middle-income countries: data from a randomised controlled trial Open
Objective To evaluate the accuracy of neonatal MRI and general movements assessment (GMA) in predicting neurodevelopmental outcomes in infants with hypoxic-ischaemic encephalopathy (HIE). Design Secondary analyses of a randomised controlle…
View article: Phototherapy for neonatal hyperbilirubinaemia
Phototherapy for neonatal hyperbilirubinaemia Open
Although hyperbilirubinaemia is a leading cause of neonatal admissions and phototherapy is the most commonly used treatment, many aspects of phototherapy remain ambiguous due to paucity of evidence. Addressing one such area, the study publ…
View article: Parechovirus infection as a cause of necrotising enterocolitis in a premature neonate
Parechovirus infection as a cause of necrotising enterocolitis in a premature neonate Open
Parechovirus is becoming increasingly recognised as a cause of morbidity in the neonatal population. It is widely known to cause sepsis, encephalitis and myocarditis. We report a case of parechovirus as a possible cause of necrotising ente…
View article: Colonization of the preterm neonatal gut with carbapenem-resistant Enterobacteriaceae and its association with neonatal sepsis and maternal gut flora
Colonization of the preterm neonatal gut with carbapenem-resistant Enterobacteriaceae and its association with neonatal sepsis and maternal gut flora Open
The results show that neonatal gut is colonized by GNB from birth onward. However, the rate of colonization with CRO is low. An association was also observed between colonization and late-onset sepsis.
View article: Therapeutic hypothermia for neonatal hypoxic-ischaemic encephalopathy in India (THIN study): a randomised controlled trial
Therapeutic hypothermia for neonatal hypoxic-ischaemic encephalopathy in India (THIN study): a randomised controlled trial Open
Objective To evaluate the neuroprotective effect of therapeutic hypothermia (TH) induced by phase changing material (PCM) on MRI biomarkers in infants with hypoxic-ischaemic encephalopathy (HIE) in a low-resource setting. Design Open-label…
View article: Vitamin D status of pregnant women and their infants in South India: VIPIS study
Vitamin D status of pregnant women and their infants in South India: VIPIS study Open
Background: Aim was to estimate the prevalence of vitamin D deficiency in pregnant women and their infants and to analyse the effect of maternal vitamin D deficiency on the infant.Methods: A prospective study was done in the Department of …
View article: Facility readiness in low and middle-income countries to address care of high risk/ small and sick newborns
Facility readiness in low and middle-income countries to address care of high risk/ small and sick newborns Open
View article: Additional file 2: of Facility readiness in low and middle-income countries to address care of high risk/ small and sick newborns
Additional file 2: of Facility readiness in low and middle-income countries to address care of high risk/ small and sick newborns Open
Table S2. Antibiotic Availability. (DOCX 17 kb)
View article: Additional file 1: of Facility readiness in low and middle-income countries to address care of high risk/ small and sick newborns
Additional file 1: of Facility readiness in low and middle-income countries to address care of high risk/ small and sick newborns Open
Facility readiness data collection tool (level II newborn care). (XLSX 29 kb)
View article: An Open-label Randomized Controlled Trial to Compare Weight Gain of Very Low Birth Weight Babies with or without Addition of Coconut Oil to Breast Milk
An Open-label Randomized Controlled Trial to Compare Weight Gain of Very Low Birth Weight Babies with or without Addition of Coconut Oil to Breast Milk Open
Oral supplementation of coconut oil along with breast milk did not increase growth parameters or result in change in body composition in very low birth weight (VLBW) babies.
View article: Cytomegalovirus Enterocolitis in a Term Neonate
Cytomegalovirus Enterocolitis in a Term Neonate Open
Background Cytomegalovirus (CMV) enterocolitis is rare in term neonates. Case characteristics A term newborn with persistent pneumonia from birth developed enterocolitis on day 18 of life. Outcome Polymerase chain reaction (PCR) for CMV DN…
View article: High versus standard volume enteral feeds to promote growth in preterm or low birth weight infants
High versus standard volume enteral feeds to promote growth in preterm or low birth weight infants Open
We found only very limited data from one small unblinded trial on the effects of high-volume feeds on important outcomes for preterm or low birth weight infants. The quality of evidence is low to very low. Hence, available evidence is insu…
View article: Prevalence of group B Streptococcal colonization among pregnant women and neonates in a tertiary hospital in India
Prevalence of group B Streptococcal colonization among pregnant women and neonates in a tertiary hospital in India Open
Though lower than rates from most countries, 7.6% of mothers attending an antenatal clinic in south India were colonized with GBS. Use of enrichment media markedly increased the detection rate. Approximately two-thirds of newborn born to c…
View article: High versus standard volumes of enteral feeds for preterm or low birth weight infants
High versus standard volumes of enteral feeds for preterm or low birth weight infants Open
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effects of a policy of feeding preterm or LBW infants with high (> 200 mL/kg/day) versus standard (≤ 200 mL/kg/day) volumes of milk. Infa…
View article: Comparison of Two Low-cost Methods of Cooling Neonates with Hypoxic Ischemic Encephalopathy
Comparison of Two Low-cost Methods of Cooling Neonates with Hypoxic Ischemic Encephalopathy Open
Both FGP and PCM are effective and safe, comparable with standard servo-controlled cooling equipment. PCM has the advantage of better maintenance of target temperature with less nursing input, when compared with FGP.
View article: Unusual complications of placental chorioangioma: consumption coagulopathy and hypertension in a preterm newborn
Unusual complications of placental chorioangioma: consumption coagulopathy and hypertension in a preterm newborn Open
We report a case of a preterm neonate born to a mother with giant placental chorioangioma. The baby had microangiopathic haemolytic anaemia, thrombocytopenia and cardiac failure at birth. In addition, she had a disseminated intravascular c…
View article: Nutritional care of preterm infants
Nutritional care of preterm infants Open
With the increasing survival of preterm infants the concept of “neurological intact survival” rather than just ‘survival’ has become important. Along with initiation of advanced cardio-respiratory support, a physician caring for a preterm …
View article: Advantages of being diligent: lessons learnt from umbilical venous catheterisation in neonates
Advantages of being diligent: lessons learnt from umbilical venous catheterisation in neonates Open
Umbilical venous catheters (UVCs) are commonly used in neonatal units. Abdominal radiograph, taken soon after the insertion, is used to confirm the correct placement of the catheter. However, as demonstrated by our case series, complacency…
View article: Appearances are Deceptive – Passing a Nasogastric Tube does Not Always Rule Out Oesophageal Atresia
Appearances are Deceptive – Passing a Nasogastric Tube does Not Always Rule Out Oesophageal Atresia Open
Oesophageal atresia/trachea-Oesophageal fistula is commonly diagnosed in the newborn period by inability to pass a nasogastric tube (NGT). We present the instance of a newborn baby where the diagnosis of oesophageal atresia was delayed bec…
View article: Contents Vol. 107, 2015
Contents Vol. 107, 2015 Open
View article: A peculiar cause for metabolic acidosis in the newborn.
A peculiar cause for metabolic acidosis in the newborn. Open
Metabolic acidosis is often encountered in a sick neonate and intestinal duplication with heterotopic gastric mucosa is a well-established condition. We present a previously unreported relationship between neonatal metabolic acidosis, resu…