Nisha Patel
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View article: B-298 Impact of In-House Methotrexate Serum Testing on Clinical Management and Patient Discharge in Acute Lymphoblastic Leukemia
B-298 Impact of In-House Methotrexate Serum Testing on Clinical Management and Patient Discharge in Acute Lymphoblastic Leukemia Open
Background Methotrexate (MTX) is a critical chemotherapeutic agent for leukemia, particularly acute lymphoblastic leukemia (ALL), and for central nervous system prophylaxis. Due to its narrow therapeutic index and the risk of toxicity, the…
View article: The effect of music and distraction on pain and anxiety during colonoscopy: a systematic review and meta-analysis
The effect of music and distraction on pain and anxiety during colonoscopy: a systematic review and meta-analysis Open
Background: Music has been shown to reduce pain and anxiety in patients undergoing colonoscopy. Distraction, a newer technique with less available evidence, has shown similar effective outcomes. Objectives: This systematic review and meta-…
View article: Impact of Methicillin-Resistant <i>Staphylococcus aureus</i> Nasal PCR Versus Culture on Vancomycin Utilization in Pneumonia Management
Impact of Methicillin-Resistant <i>Staphylococcus aureus</i> Nasal PCR Versus Culture on Vancomycin Utilization in Pneumonia Management Open
Introduction: Methicillin-resistant Staphylococcus aureus pneumonia (PNA) can be ruled out via methicillin-resistant Staphylococcus aureus (MRSA) culture and polymerase chain reaction (PCR) nasal screening, facilitating the de-escalation o…
View article: Reducing applied force in colonoscopy using a novel soft robotic colonoscope: Head-to-head study
Reducing applied force in colonoscopy using a novel soft robotic colonoscope: Head-to-head study Open
Current colonoscopies have a recognized limitation. Manual pushing and pulling required by operators provides gross movement in the bowel. Reported pain, therefore, is likely due to the manual force applied. Implementing novel steering tec…
View article: The Role of injectable platelet-rich fibrin(i-PRF) and Advanced platelet-rich fibrin(A-PRF) in Androgenetic Alopecia: A New Frontier in Hair Regeneration
The Role of injectable platelet-rich fibrin(i-PRF) and Advanced platelet-rich fibrin(A-PRF) in Androgenetic Alopecia: A New Frontier in Hair Regeneration Open
Androgenetic alopecia (AGA) is a prevalent condition that causes progressive hair thinning and loss, affecting both men and women. Despite existing treatments, their efficacy is inconsistent, leading to the exploration of alternative thera…
View article: The Role of injectable platelet-rich fibrin(i-PRF) and Advanced platelet-rich fibrin(A-PRF) in Androgenetic Alopecia: A New Frontier in Hair Regeneration
The Role of injectable platelet-rich fibrin(i-PRF) and Advanced platelet-rich fibrin(A-PRF) in Androgenetic Alopecia: A New Frontier in Hair Regeneration Open
Androgenetic alopecia (AGA) is a prevalent condition that causes progressive hair thinning and loss, affecting both men and women. Despite existing treatments, their efficacy is inconsistent, leading to the exploration of alternative thera…
View article: Silver Diamine Fluoride in Pediatric Dentistry: A Systematic Review of Its Efficacy in Arresting Caries in Primary Teeth
Silver Diamine Fluoride in Pediatric Dentistry: A Systematic Review of Its Efficacy in Arresting Caries in Primary Teeth Open
Background Dental caries in primary teeth is a widespread issue, ranking as one of the most prevalent conditions globally, as highlighted in the Global Burden of Disease 2010 Study. Despite preventive efforts, such as the use of fluoride t…
View article: A UK single‐center pilot experience using a novel robotic inchworm colonoscopy system
A UK single‐center pilot experience using a novel robotic inchworm colonoscopy system Open
Introduction Colonoscopy is the gold standard investigation in the lower gastrointestinal tract. However, 75% of patients can experience pain with moderate sedation. The application of robotic technology aims to overcome difficulties faced…
View article: <i>CRLF2</i>-rearranged B-cell ALL with extramedullary lineage switch to AML following CD19-targeted therapy
<i>CRLF2</i>-rearranged B-cell ALL with extramedullary lineage switch to AML following CD19-targeted therapy Open
Lineage switch (LS) refers to the immunophenotypic transformation of one leukemia lineage to another (ie, lymphoid to myeloid) with retention of baseline genetics. This phenomenon was originally observed in infants with B-lymphoblastic leu…
View article: Eye-controlled endoscopy — a benchtop trial of a novel robotic steering platform — iGAZE2
Eye-controlled endoscopy — a benchtop trial of a novel robotic steering platform — iGAZE2 Open
View article: Enhancing the diagnosis of hypertrophic cardiomyopathy diagnosis: a case of integrating cardiac magnetic resonance imaging with transthoracic echocardiography
Enhancing the diagnosis of hypertrophic cardiomyopathy diagnosis: a case of integrating cardiac magnetic resonance imaging with transthoracic echocardiography Open
View article: A review of bioinspired locomotion in lower GI endoscopy
A review of bioinspired locomotion in lower GI endoscopy Open
Flexible endoscopy is the gold standard modality for diagnosis and therapeutic intervention of various colorectal conditions. A high bar is currently set for any new technology to replace the current modern colonoscope, but limitations do …
View article: Real-time classification of tumour and non-tumour tissue in colorectal cancer using diffuse reflectance spectroscopy and neural networks to aid margin assessment
Real-time classification of tumour and non-tumour tissue in colorectal cancer using diffuse reflectance spectroscopy and neural networks to aid margin assessment Open
Background: Colorectal cancer is the third most commonly diagnosed malignancy and the second leading cause of mortality worldwide. A positive resection margin following surgery for colorectal cancer is linked with higher rates of local rec…
View article: Development and validation of machine learning models to predict the need for haemostatic therapy in acute upper gastrointestinal bleeding
Development and validation of machine learning models to predict the need for haemostatic therapy in acute upper gastrointestinal bleeding Open
Background: Acute upper gastrointestinal bleeding (AUGIB) is a major cause of morbidity and mortality. This presentation however is not universally high risk as only 20–30% of bleeds require urgent haemostatic therapy. Nevertheless, the cu…
View article: Causes of intraprocedural discomfort in colonoscopy: a review and practical tips
Causes of intraprocedural discomfort in colonoscopy: a review and practical tips Open
Colonoscopy is a commonly performed procedure in the United Kingdom and the gold standard for diagnosis and therapy in the gastrointestinal tract. Increased levels of pain during colonoscopy have been associated with reduced completion rat…
View article: AB014. Bone marrow dyscrasias in autoimmune regulator deficiency: lessons from thymoma and autoimmune polyendocrinopathy-candidiasis ectodermal dystrophy
AB014. Bone marrow dyscrasias in autoimmune regulator deficiency: lessons from thymoma and autoimmune polyendocrinopathy-candidiasis ectodermal dystrophy Open
BACKGROUND: The autoimmune regulator (AIRE) gene plays a crucial role in the development of immunological self-tolerance. Primary mutations can lead to autoimmune polyendocrinopathy-candidiasis ectodermal dystrophy (APECED) whereas decreas…
View article: Transient responses and significant toxicities of anti-CD30 CAR T cells for CD30+ lymphomas: results of a phase 1 trial
Transient responses and significant toxicities of anti-CD30 CAR T cells for CD30+ lymphomas: results of a phase 1 trial Open
New treatments are needed for relapsed and refractory CD30-expressing lymphomas. We developed a novel anti-CD30 chimeric antigen receptor (CAR), designated 5F11-28Z. Safety and feasibility of 5F11-28Z–transduced T cells (5F11-Ts) were eval…
View article: Natural history study of patients with familial platelet disorder with associated myeloid malignancy
Natural history study of patients with familial platelet disorder with associated myeloid malignancy Open
Deleterious germ line RUNX1 variants cause the autosomal dominant familial platelet disorder with associated myeloid malignancy (FPDMM), characterized by thrombocytopenia, platelet dysfunction, and a predisposition to hematologic malignanc…
View article: How I diagnose myeloid neoplasms with germline predisposition
How I diagnose myeloid neoplasms with germline predisposition Open
Objectives Pathologists play a crucial role in the initial diagnosis of germline predisposition to myeloid neoplasia and subsequent surveillance for disease progression. The diagnostic workup can be challenging, particularly if clinical hi…
View article: A YOLOv5-based network for the detection of a diffuse reflectance spectroscopy probe to aid surgical guidance in gastrointestinal cancer surgery
A YOLOv5-based network for the detection of a diffuse reflectance spectroscopy probe to aid surgical guidance in gastrointestinal cancer surgery Open
View article: Determinants of post-operative left ventricular dysfunction in degenerative mitral regurgitation
Determinants of post-operative left ventricular dysfunction in degenerative mitral regurgitation Open
Funding Acknowledgements Type of funding sources: Private grant(s) and/or Sponsorship. Main funding source(s): The Saudi Arabian Cultural Bureau. Background Chronic degenerative mitral regurgitation leads to volume overload causing left ve…
View article: A rare case of well-differentiated systemic mastocytosis
A rare case of well-differentiated systemic mastocytosis Open
A 20-year-old man diagnosed with urticaria pigmentosa at age 2 presented with rising tryptase levels (89.2 ng/mL [normal < 11.5 ng/mL]) and increased episodes of flushing.Complete blood count results were within normal limits.A bone marrow…
View article: Orientation in upper gastrointestinal endoscopy—the only way is up
Orientation in upper gastrointestinal endoscopy—the only way is up Open
The majority of endoscopists surveyed were unable to identify key landmarks within the UGI tract. Endoscopic orientation appears to improve with experience yet there are some areas still not well recognised. This has potential considerable…
View article: Derivation and validation of a novel risk score to predict need for haemostatic intervention in acute upper gastrointestinal bleeding (London Haemostat Score)
Derivation and validation of a novel risk score to predict need for haemostatic intervention in acute upper gastrointestinal bleeding (London Haemostat Score) Open
Background Acute upper gastrointestinal bleeding (AUGIB) is a common medical emergency, which takes up considerable healthcare resources. However, only approximately 20%–30% of bleeds require urgent haemostatic intervention. Current standa…
View article: The future of endoscopy – what are the thoughts on artificial intelligence?
The future of endoscopy – what are the thoughts on artificial intelligence? Open
There is an emerging role of artificial intelligence (AI) in endoscopy with studies on early systems showing promising results. However, various limitations inhibit widespread use. The aim of this study was to ascertain the sentiments of e…
View article: Safety and Performance of Narhinel 0.9% Sodium Chloride Monodose and Otrisal 0.74% Sodium Chloride Monodose Nasal Saline Solutions and Nasal Aspirators in Real-World Settings: Postmarket Clinical Follow-up Study Results
Safety and Performance of Narhinel 0.9% Sodium Chloride Monodose and Otrisal 0.74% Sodium Chloride Monodose Nasal Saline Solutions and Nasal Aspirators in Real-World Settings: Postmarket Clinical Follow-up Study Results Open
These data support the safety and performance of 2 monodose saline solutions (Narhinel and Otrisal) for nasal cleansing, nasal moisturization, and/or loosening nasal secretions, and of nasal aspirators (with hard- and soft-nozzle refills) …
View article: Real-World Safety and Performance of Saline Nasal Spray Products for Nasal Cleansing and Reducing Obstruction of the Nasal Cavity
Real-World Safety and Performance of Saline Nasal Spray Products for Nasal Cleansing and Reducing Obstruction of the Nasal Cavity Open
Background and Objectives: Three post-marketing clinical follow-up studies were performed in Europe to confirm the safety and performance of four nonprescription, nasal cleansing medical devices: Otrivin Sea Water (OSW) pressurized spray, …
View article: Eye tracking technology in endoscopy: Looking to the future
Eye tracking technology in endoscopy: Looking to the future Open
The visual patterns of an endoscopist, that is, what the endoscopist is looking at during luminal endoscopy, is an interesting area with an evolving evidence base. The tools required for gaze analysis have become cheaper and more easily ac…
View article: Pectoralis major tendon to scapula transfer
Pectoralis major tendon to scapula transfer Open
View article: Real-time Tracking and Classification of Tumor and Nontumor Tissue in Upper Gastrointestinal Cancers Using Diffuse Reflectance Spectroscopy for Resection Margin Assessment
Real-time Tracking and Classification of Tumor and Nontumor Tissue in Upper Gastrointestinal Cancers Using Diffuse Reflectance Spectroscopy for Resection Margin Assessment Open
Importance Cancers of the upper gastrointestinal tract remain a major contributor to the global cancer burden. The accurate mapping of tumor margins is of particular importance for curative cancer resection and improvement in overall survi…