Nirav Raval
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View article: Multimodal molecular testing provides prognostic value for heart transplant recipients
Multimodal molecular testing provides prognostic value for heart transplant recipients Open
Patients with dual positive GEP and dd-cfDNA are at increased risk for subsequent GD and CV death, even in the absence of histological evidence of rejection, indicating circulating multimodal molecular evidence of rejection provides progno…
View article: AI-based approach for heart failure readmission prediction using SCG, ECG, and GSR signals
AI-based approach for heart failure readmission prediction using SCG, ECG, and GSR signals Open
Objective. Heart failure (HF) is considered a global pandemic because of increasing prevalence, high mortality rate, frequent hospitalization, and associated economic burden. This study explores a noninvasive method that may help in managi…
View article: Surveillance with dual noninvasive testing for acute cellular rejection after heart transplantation: Outcomes from the Surveillance HeartCare Outcomes Registry
Surveillance with dual noninvasive testing for acute cellular rejection after heart transplantation: Outcomes from the Surveillance HeartCare Outcomes Registry Open
Dual molecular testing demonstrated improved performance for ACR surveillance compared to single molecular testing. The use of dual noninvasive testing was associated with lower biopsy rates over time, excellent survival, and low incidence…
View article: Heart Failure Readmission Prediction Using Seismocardiogram Signal
Heart Failure Readmission Prediction Using Seismocardiogram Signal Open
Heart failure (HF) is considered a global pandemic because of increasing prevalence, high mortality rate, frequent hospitalization and associated economic burden. This study explores a noninvasive method that may help in managing HF patien…
View article: ARTIFICIAL INTELLIGENCE IN CYBERSECURITY: ADVANCING THREAT DETECTION, RESPONSE, AND PRIVACY PRESERVATION IN THE DIGITAL ERA
ARTIFICIAL INTELLIGENCE IN CYBERSECURITY: ADVANCING THREAT DETECTION, RESPONSE, AND PRIVACY PRESERVATION IN THE DIGITAL ERA Open
The exponential growth of digital technologies has amplified both opportunities and risks in the cybersecurity domain. With the rising frequency and sophistication of cyberattacks, traditional rule-based and signature-driven defense mechan…
View article: Pulmonary Artery Pressure-Guided Heart Failure Management Reduces Hospitalizations in Patients With Chronic Kidney Disease
Pulmonary Artery Pressure-Guided Heart Failure Management Reduces Hospitalizations in Patients With Chronic Kidney Disease Open
Background: Hemodynamic-guided heart failure management is a superior strategy to prevent decompensation leading to hospitalization compared with traditional clinical methods. It remains unstudied if hemodynamic-guided care is effective ac…
View article: Sustained Reduction in Pulmonary Artery Pressures and Hospitalizations During 2 Years of Ambulatory Monitoring
Sustained Reduction in Pulmonary Artery Pressures and Hospitalizations During 2 Years of Ambulatory Monitoring Open
Reduction in PA pressures and hospitalizations were early and sustained during 2 years of PA pressure-guided management, with no signal of safety concerns regarding the implanted sensor.
View article: Renin Angiotensin Aldosterone System Antagonism in 2019 Novel Coronavirus Acute Lung Injury
Renin Angiotensin Aldosterone System Antagonism in 2019 Novel Coronavirus Acute Lung Injury Open
It has been established that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses angiotensin-converting enzyme 2 (ACE2), a membrane-bound regulatory peptide, for host cell entry. Renin-angiotensin-aldosterone system (RAAS) in…
View article: Lower Rates of Heart Failure and All-Cause Hospitalizations During Pulmonary Artery Pressure-Guided Therapy for Ambulatory Heart Failure
Lower Rates of Heart Failure and All-Cause Hospitalizations During Pulmonary Artery Pressure-Guided Therapy for Ambulatory Heart Failure Open
Background: Ambulatory hemodynamic monitoring with an implantable pulmonary artery (PA) sensor is approved for patients with New York Heart Association Class III heart failure (HF) and a prior HF hospitalization (HFH) within 12 months. The…
View article: A comprehensive individual patient data meta‐analysis of the effects of cardiac contractility modulation on functional capacity and heart failure‐related quality of life
A comprehensive individual patient data meta‐analysis of the effects of cardiac contractility modulation on functional capacity and heart failure‐related quality of life Open
Aims Cardiac contractility modulation, also referred to as CCM™, has emerged as a promising device treatment for heart failure (HF) in patients not indicated for cardiac resynchronization therapy. We performed a comprehensive individual pa…
View article: Clinical Outcomes and Quality of Life With an Ambulatory Counterpulsation Pump in Advanced Heart Failure Patients
Clinical Outcomes and Quality of Life With an Ambulatory Counterpulsation Pump in Advanced Heart Failure Patients Open
Background: The NuPulseCV intravascular ventricular assist system (iVAS) provides extended duration ambulatory counterpulsation via a durable pump placed through the distal subclavian artery. Methods: We performed a prospective, single-arm…
View article: Association of Clinical Outcomes With Left Ventricular Assist Device Use by Bridge to Transplant or Destination Therapy Intent
Association of Clinical Outcomes With Left Ventricular Assist Device Use by Bridge to Transplant or Destination Therapy Intent Open
ClinicalTrials.gov identifier: NCT02224755.
View article: A Fully Magnetically Levitated Left Ventricular Assist Device — Final Report
A Fully Magnetically Levitated Left Ventricular Assist Device — Final Report Open
Among patients with advanced heart failure, a fully magnetically levitated centrifugal-flow left ventricular assist device was associated with less frequent need for pump replacement than an axial-flow device and was superior with respect …
View article: Impact of age, sex, therapeutic intent, race and severity of advanced heart failure on short-term principal outcomes in the MOMENTUM 3 trial
Impact of age, sex, therapeutic intent, race and severity of advanced heart failure on short-term principal outcomes in the MOMENTUM 3 trial Open
This analysis of MOMENTUM 3 suggests that younger age (≤65 years) at implant and pump choice are associated with a greater likelihood of primary end-point success. These findings further suggest that characterization of therapeutic intent …
View article: Outcomes of Patients Implanted With a Left Ventricular Assist Device at Nontransplant Mechanical Circulatory Support Centers
Outcomes of Patients Implanted With a Left Ventricular Assist Device at Nontransplant Mechanical Circulatory Support Centers Open
The goal of this study was to assess outcomes of patients who underwent implantation of left ventricular assist devices (LVADs) at nontransplantation mechanical circulatory support centers. As the availability of LVADs for advanced heart f…