Nirmal Kumar Sampathkumar
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View article: Aging murine peritoneal macrophages undergo female-specific remodeling driven by hormone-dependent and independent mechanisms
Aging murine peritoneal macrophages undergo female-specific remodeling driven by hormone-dependent and independent mechanisms Open
Aging is a complex process characterized by a progressive decline in physiological functions driven by both biological and environmental factors, with notable differences between sexes. Immune function is strongly influenced by biological …
View article: Sex‐dimorphic gene regulation in murine macrophages across niches
Sex‐dimorphic gene regulation in murine macrophages across niches Open
Macrophages are a key cell type of the innate immune system and are involved at all steps of inflammation: (i) they present antigens to initiate inflammation, (ii) they clear up foreign bodies through phagocytosis and (iii) they resolve in…
View article: Sex-dimorphic gene regulation in murine macrophages across niches
Sex-dimorphic gene regulation in murine macrophages across niches Open
Macrophages are a key cell type of the innate immune system and are involved at all steps of inflammation: (i) they present antigens to initiate inflammation, (ii) they clear up foreign bodies through phagocytosis, and (iii) they resolve i…
View article: Olanzapine, Risperidone and Clozapine prescribing is associated with increased risk for Alzheimer’s Disease reflecting antipsychotic-specific effects on microglial phagocytosis
Olanzapine, Risperidone and Clozapine prescribing is associated with increased risk for Alzheimer’s Disease reflecting antipsychotic-specific effects on microglial phagocytosis Open
Epidemiological data provides evidence for a positive correlation between schizophrenia diagnosis and an increased risk to develop dementia. Whether and how use of antipsychotic medication may contribute to this association is however unkn…
View article: Heterozygous expression of the Alzheimer’s disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses
Heterozygous expression of the Alzheimer’s disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses Open
Background A rare coding variant, P522R , in the phospholipase C gamma 2 ( PLCG2) gene has been identified as protective against late-onset Alzheimer’s disease (AD), but the mechanism is unknown. PLCG2 is exclusively expressed in microglia…
View article: Heterozygous expression of the Alzheimer’s disease protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses.
Heterozygous expression of the Alzheimer’s disease protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses. Open
BACKGROUND: A rare coding variant, P522R, in the phosphoplipase C gamme 2 (PLCG2) gene has been identified as protective against late onset Alzheimer’s disease (AD), but the mechanism is unknown. PLCG2 is exclusively expressed in microglia…
View article: Heterozygous expression of the Alzheimer’s disease protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses.
Heterozygous expression of the Alzheimer’s disease protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses. Open
Background: A rare coding variant, P522R, in the phosphoplipase C gamme 2 (PLCG2) gene has been identified as protective against late onset Alzheimer’s disease (AD), but the mechanism of protection is unknown. PLCG2 is exclusively expresse…
View article: RNA-Seq is not required to determine stable reference genes for qPCR normalization
RNA-Seq is not required to determine stable reference genes for qPCR normalization Open
Assessment of differential gene expression by qPCR is heavily influenced by the choice of reference genes. Although numerous statistical approaches have been proposed to determine the best reference genes, they can give rise to conflicting…
View article: RNA-Seq is not required to determine stable reference genes for qPCR normalization
RNA-Seq is not required to determine stable reference genes for qPCR normalization Open
Assessment of differential gene expression by qPCR is heavily influenced by the choice of reference genes. Although numerous statistical approaches have been proposed to determine the best reference genes, they can give rise to conflicting…
View article: Multi-omic profiling of primary mouse neutrophils predicts a pattern of sex- and age-related functional regulation
Multi-omic profiling of primary mouse neutrophils predicts a pattern of sex- and age-related functional regulation Open
View article: RNAseq is not required to determine stable reference genes for qPCR normalization
RNAseq is not required to determine stable reference genes for qPCR normalization Open
The original contributions presented in the study are included in the article & Supplementary Data. The metadata for the RNA-Seq and qPCR include the normalized count matrices for the RNAseq data, qPCR Cq values and differential expression…
View article: RNAseq is not required to determine stable reference genes for qPCR normalization
RNAseq is not required to determine stable reference genes for qPCR normalization Open
The original contributions presented in the study are included in the article & Supplementary Data. The metadata for the RNA-Seq and qPCR include the normalized count matrices for the RNAseq data, qPCR Cq values and differential expression…
View article: Sex-Dimorphism in Aging Gene Regulation: Are We Missing Half of the Picture?
Sex-Dimorphism in Aging Gene Regulation: Are We Missing Half of the Picture? Open
The existence of human supercentenarians reveals a surprising predictor for exceptional longevity: being female. Not only are 33 out of 34 living supercentenarians women, women are also more resistant to most diseases responsible for age-r…
View article: Multi-omic profiling of primary mouse neutrophils reveals a pattern of sex and age-related functional regulation
Multi-omic profiling of primary mouse neutrophils reveals a pattern of sex and age-related functional regulation Open
Summary Neutrophils are the most abundant white blood cells in humans and constitute one of the first lines of defense in the innate immune response. Neutrophils are extremely short-lived cells, which survive less than a day after reaching…
View article: Measuring Phagocytosis in Bone Marrow-Derived Macrophages and Peritoneal Macrophages with Aging
Measuring Phagocytosis in Bone Marrow-Derived Macrophages and Peritoneal Macrophages with Aging Open
View article: INVESTIGATING THE ROLE OF AHR IN MEDIATING SEX DIFFERENCES OF AGING MACROPHAGES
INVESTIGATING THE ROLE OF AHR IN MEDIATING SEX DIFFERENCES OF AGING MACROPHAGES Open
“Inflamm-aging” describes a state of chronic low-grade inflammation which occurs with age in the absence of infection. This process is related to many chronic age-related diseases. Aryl hydrocarbon receptor (Ahr), is a transcription factor…
View article: SEX-DIMORPHISM IN THE GENOMIC REGULATION OF AGING
SEX-DIMORPHISM IN THE GENOMIC REGULATION OF AGING Open
The current cohort of human supercentenarians reveals a surprising predictor for achieving such an exceptional longevity: being female. Indeed, out of 34 living supercentenarians, 33 are women. We obtained samples from 4 and 20 months old …
View article: Widespread sex dimorphism in aging and age-related diseases
Widespread sex dimorphism in aging and age-related diseases Open
View article: Optimal use of statistical methods to validate reference gene stability in longitudinal studies
Optimal use of statistical methods to validate reference gene stability in longitudinal studies Open
Multiple statistical approaches have been proposed to validate reference genes in qPCR assays. However, conflicting results from these statistical methods pose a major hurdle in the choice of the best reference genes. Recent studies have p…
View article: Optimal use of statistical methods to validate reference gene stability in longitudinal studies
Optimal use of statistical methods to validate reference gene stability in longitudinal studies Open
Multiple statistical approaches have been proposed to validate reference genes in qPCR assays. However, conflicting results from these statistical methods pose a major hurdle in the choice of the best reference genes. Indeed, as their resp…
View article: Multi-level remodeling of transcriptional landscapes in aging and longevity
Multi-level remodeling of transcriptional landscapes in aging and longevity Open
In multi-cellular organisms, the control of gene expression is key not only for development, but also for adult cellular homeostasis, and gene expression has been observed to be deregulated with aging. In this review, we discuss the curren…
View article: Involvement of Aryl hydrocarbon receptor in myelination and in human nerve sheath tumorigenesis
Involvement of Aryl hydrocarbon receptor in myelination and in human nerve sheath tumorigenesis Open
Significance Aryl hydrocarbon receptor (AHR) is well known to mediate xenobiotic metabolism in vertebrates. Growing evidence reveals that AHR seems to have endogenous roles in the development and functioning of different organs. In our cur…