Nirmalya Dasgupta
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View article: p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells
p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells Open
Genomic instability and inflammation are distinct hallmarks of aging, but the connection between them is poorly understood. Here we report a mechanism directly linking genomic instability and inflammation in senescent cells through a mitoc…
View article: The role of the dynamic epigenetic landscape in senescence: orchestrating SASP expression
The role of the dynamic epigenetic landscape in senescence: orchestrating SASP expression Open
Senescence and epigenetic alterations stand out as two well-characterized hallmarks of aging. When cells become senescent, they cease proliferation and release inflammatory molecules collectively termed the Senescence-Associated Secretory …
View article: Linked regulation of genome integrity and senescence-associated inflammation by p53
Linked regulation of genome integrity and senescence-associated inflammation by p53 Open
Genomic instability and inflammation are distinct hallmarks of aging, but the connection between them is poorly understood. Understanding their interrelationship will help unravel new mechanisms and therapeutic targets of aging and age-ass…
View article: Hematopoiesis: a <scp>BETter</scp> understanding
Hematopoiesis: a <span>BETter</span> understanding Open
View article: Histone chaperone HIRA, Promyelocytic Leukemia (PML) protein and p62/SQSTM1 coordinate to regulate inflammation during cell senescence
Histone chaperone HIRA, Promyelocytic Leukemia (PML) protein and p62/SQSTM1 coordinate to regulate inflammation during cell senescence Open
Summary Cellular senescence, a stress-induced stable proliferation arrest associated with an inflammatory Senescence-Associated Secretory Phenotype (SASP), is a cause of aging. In senescent cells, Cytoplasmic Chromatin Fragments (CCFs) act…
View article: Large‐scale genetic screens identify <scp>BET</scp>‐1 as a cytoskeleton regulator promoting actin function and life span
Large‐scale genetic screens identify <span>BET</span>‐1 as a cytoskeleton regulator promoting actin function and life span Open
The actin cytoskeleton is a three‐dimensional scaffold of proteins that is a regulatory, energyconsuming network with dynamic properties to shape the structure and function of the cell. Proper actin function is required for many cellular p…
View article: Cytoplasmic DNA: sources, sensing, and role in aging and disease
Cytoplasmic DNA: sources, sensing, and role in aging and disease Open
View article: Cytoplasmic chromatin fragments—from mechanisms to therapeutic potential
Cytoplasmic chromatin fragments—from mechanisms to therapeutic potential Open
Senescent cells, damaged cells that permanently exit the cell cycle, play important roles in development, tissue homeostasis, and tumorigenesis. Although many of these roles are beneficial in acute responses to stress and damage, the persi…
View article: Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence
Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence Open
Cellular senescence is a potent tumor suppressor mechanism but also contributes to aging and aging-related diseases. Senescence is characterized by a stable cell cycle arrest and a complex proinflammatory secretome, termed the senescence-a…
View article: Author Index
Author Index Open
View article: The HIRA histone chaperone complex subunit UBN1 harbors H3/H4- and DNA-binding activity
The HIRA histone chaperone complex subunit UBN1 harbors H3/H4- and DNA-binding activity Open
View article: Physiological TLR5 expression in the intestine is regulated by differential DNA binding of Sp1/Sp3 through simultaneous Sp1 dephosphorylation and Sp3 phosphorylation by two different PKC isoforms
Physiological TLR5 expression in the intestine is regulated by differential DNA binding of Sp1/Sp3 through simultaneous Sp1 dephosphorylation and Sp3 phosphorylation by two different PKC isoforms Open
Toll-like receptor 5 (TLR5) expression in the intestinal epithelial cells (IECs) is critical to maintain health, as underscored by multiple intestinal and extra-intestinal diseases in mice genetically engineered for IEC-specific TLR5 knock…