Nischal Ranganath
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View article: Clinical and microbiologic features of <i>Achromobacter</i> species: a 10-year, multicenter experience
Clinical and microbiologic features of <i>Achromobacter</i> species: a 10-year, multicenter experience Open
Achromobacter species are Gram-negative bacilli that predominantly affect individuals with cystic fibrosis or those with immunocompromising conditions. Clinical and microbiologic data on Achromobacter species are limited due to the rarity …
View article: From Culture-Negative to DNA-Positive: The Molecular Revolution in Infective Endocarditis Diagnosis
From Culture-Negative to DNA-Positive: The Molecular Revolution in Infective Endocarditis Diagnosis Open
Infective endocarditis (IE) remains a diagnostic challenge, particularly in cases where microbiological diagnosis is not established. Advances in molecular diagnostics have expanded the ability to identify causative pathogens beyond tradit…
View article: Plasma Quantitative Microbial Cell-Free DNA for Staphylococcal Cardiac Implantable Electronic Device Infection—Too Soon?
Plasma Quantitative Microbial Cell-Free DNA for Staphylococcal Cardiac Implantable Electronic Device Infection—Too Soon? Open
View article: Redo bilateral lung transplantation in a previous heart-lung transplant recipient for invasive pulmonary scedosporiosis
Redo bilateral lung transplantation in a previous heart-lung transplant recipient for invasive pulmonary scedosporiosis Open
View article: Illuminating the Challenges and Diagnostic Utility of Plasma Microbial Cell-Free DNA Sequencing in Suspected Infective Endocarditis: A Retrospective Observational Cohort Study
Illuminating the Challenges and Diagnostic Utility of Plasma Microbial Cell-Free DNA Sequencing in Suspected Infective Endocarditis: A Retrospective Observational Cohort Study Open
Background Infective endocarditis (IE) is a life-threatening infection often challenging to diagnose, particularly in culture-negative cases. Plasma microbial cell-free DNA (mcfDNA) sequencing has shown potential for detecting pathogens in…
View article: From Chart Biopsy to Liquid Biopsy: Evaluating the Diagnostic Yield and Clinical Impact of Plasma Microbial Cell-Free DNA Next-Generation Sequencing in the Management of Fever of Unknown Origin
From Chart Biopsy to Liquid Biopsy: Evaluating the Diagnostic Yield and Clinical Impact of Plasma Microbial Cell-Free DNA Next-Generation Sequencing in the Management of Fever of Unknown Origin Open
Background The underlying cause of fever of unknown origin (FUO) remains unidentified in up to 51% of cases despite systematic evaluation. Microbial cell-free DNA next-generation sequencing (mcfDNA-NGS) offers an agnostic, noninvasive appr…
View article: P-1043. Risk Factors for Breakthrough Invasive Mold Infections in Patients with Hematologic Malignancies
P-1043. Risk Factors for Breakthrough Invasive Mold Infections in Patients with Hematologic Malignancies Open
Background Invasive mold infections (IMI) lead to significant morbidity and mortality in patients with hematologic malignancies. We provide patients deemed at higher risk mold active prophylaxis but still observe breakthrough IMIs. The pur…
View article: P-2228. Utility of Microbial Cell-Free DNA Next-Generation Sequencing for Evaluation of Vascular Graft Infection
P-2228. Utility of Microbial Cell-Free DNA Next-Generation Sequencing for Evaluation of Vascular Graft Infection Open
Background Vascular graft infection (VGI) is a rare but serious condition. Pathogen identification can be difficult given the deep-seated nature. Microbial cell-free DNA next-generation sequencing (mcfDNA NGS) is an emerging tool in non-in…
View article: P-2164. Diagnostic Utility of Plasma Microbial Cell-free DNA Sequencing in Suspected Infective Endocarditis and the Impact on Treatment Decisions
P-2164. Diagnostic Utility of Plasma Microbial Cell-free DNA Sequencing in Suspected Infective Endocarditis and the Impact on Treatment Decisions Open
Background Plasma microbial cell-free DNA (mcfDNA) sequencing, commercially available from Karius® (Redwood City, CA), has been increasingly utilized in diagnosing endovascular infections. The 2023 updated Duke criteria incorporated detect…
View article: P-2223. Plasma Microbial Cell-free DNA Next-generation Sequencing can be a Useful Diagnostic Tool in Patients with Osteoarticular Infections
P-2223. Plasma Microbial Cell-free DNA Next-generation Sequencing can be a Useful Diagnostic Tool in Patients with Osteoarticular Infections Open
Background The introduction of shotgun metagenomic sequencing (sMGS) methods that identify the presence of microbial cell-free DNA (mcfDNA) in peripheral blood have shown promising results in various populations of patients. There is a pre…
View article: <i>Candida guilliermondii</i> fungemia: a 12-year retrospective review of antimicrobial susceptibility patterns at a reference laboratory and tertiary care center
<i>Candida guilliermondii</i> fungemia: a 12-year retrospective review of antimicrobial susceptibility patterns at a reference laboratory and tertiary care center Open
The prevalence of invasive candidiasis caused by non- albicans Candida species is increasing. Candida guilliermondii is an infrequent cause of candidemia but has been associated with decreased susceptibility to triazoles. Clinical data rel…
View article: Plasma Microbial Cell-free DNA Next-generation Sequencing Can Be a Useful Diagnostic Tool in Patients With Osteoarticular Infections
Plasma Microbial Cell-free DNA Next-generation Sequencing Can Be a Useful Diagnostic Tool in Patients With Osteoarticular Infections Open
Background Recent advances in shotgun metagenomic sequencing (sMGS) for detecting microbial cell-free DNA (mcfDNA) in peripheral blood have shown promise across various patient populations. This study evaluates the application of sMGS for …
View article: Acute <i>Coxiella burnetii</i> Infection: A 10-Year Clinical Experience at a Tertiary Care Center in the United States
Acute <i>Coxiella burnetii</i> Infection: A 10-Year Clinical Experience at a Tertiary Care Center in the United States Open
Background Identifying and treating patients with acute Q fever who are at an increased risk of progressing to persistent disease is crucial for preventing future complications. In this study, we share our decade-long clinical experience w…
View article: <i>Rhodococcus</i> infection: a 10-year retrospective analysis of clinical experience and antimicrobial susceptibility profile
<i>Rhodococcus</i> infection: a 10-year retrospective analysis of clinical experience and antimicrobial susceptibility profile Open
Rhodococcus equi is an opportunistic pathogen known to cause pulmonary and extrapulmonary disease among immunocompromised patients. Treatment is frequently challenging due to intrinsic resistance to multiple antibiotic classes. While non- …
View article: 2432. Antibiotic Lock Therapy as a Line Salvage Strategy for Catheter-Related Bloodstream Infections: A Retrospective analysis
2432. Antibiotic Lock Therapy as a Line Salvage Strategy for Catheter-Related Bloodstream Infections: A Retrospective analysis Open
Background Catheter-related bloodstream infection (CRBSI) is an important complication of long-term central venous catheters (CVCs) and is associated with high morbidity and cost. While line removal is optimal, it is not always feasible an…
View article: 2796. A Decade of <i>Rhodococcus</i> spp. Infections: Microbiology, Antimicrobial Susceptibility, and Clinical Experience
2796. A Decade of <i>Rhodococcus</i> spp. Infections: Microbiology, Antimicrobial Susceptibility, and Clinical Experience Open
Background Rhodococcus spp. are a zoonotic, Gram-positive coccobacilli that cause pulmonary and disseminated disease in immunocompromised patients. Rhodococcus infection is associated with high morbidity and mortality and treatment can be …
View article: 565. Antimicrobial susceptibility profiles of <i>Acinetobacter</i> species in blood: 10-year experience from a major United States reference laboratory
565. Antimicrobial susceptibility profiles of <i>Acinetobacter</i> species in blood: 10-year experience from a major United States reference laboratory Open
Background Antimicrobial resistance (AMR) is a threat to healthcare, and infections with antimicrobial resistant organisms carry significant morbidity and mortality. Owing to high rates of AMR, the Centers for Disease Control and Preventio…
View article: 1779. Trends in Anaplasmosis Over the Past Decade: A Review of Clinical Features, Laboratory Data and Outcomes
1779. Trends in Anaplasmosis Over the Past Decade: A Review of Clinical Features, Laboratory Data and Outcomes Open
Background Human granulocytic anaplasmosis (HGA) is an emerging tick-borne illness endemic to the northeastern and midwestern United States. Risk factors for the severity of infection, predictors for hospitalization, temporal trends, co-in…
View article: 2823. In Vitro Efficacy of Minocycline on Clinical Gram Negative Bacterial Isolates
2823. In Vitro Efficacy of Minocycline on Clinical Gram Negative Bacterial Isolates Open
Background Urinary tract infections (UTIs) caused by multidrug-resistant Gram-negative bacilli (MDR-GNB) have become increasingly challenging to manage due to the limited number of available effective oral agents. Minocycline, a second-gen…
View article: Risk factors for positive follow‐up blood cultures in Gram‐negative bacteremia among immunocompromised patients with neutropenia
Risk factors for positive follow‐up blood cultures in Gram‐negative bacteremia among immunocompromised patients with neutropenia Open
Introduction Gram‐negative bacillary bloodstream infection (GN‐BSI) is a frequent clinical challenge among immunocompromised hosts and is associated with a high mortality. The utility of follow‐up blood cultures (FUBCs) for GN‐BSI in this …
View article: 2766. "A Retrospective Analysis of Non-Blood Sources of <i>Achromobacter</i> Infection and Antimicrobial Resistance Patterns: A Mayo Clinic Enterprise Experience"
2766. "A Retrospective Analysis of Non-Blood Sources of <i>Achromobacter</i> Infection and Antimicrobial Resistance Patterns: A Mayo Clinic Enterprise Experience" Open
Background Achromobacter spp. are important pathogens that are most frequently implicated in opportunistic infections, especially in patients with chronic lung disease, malignancy, and solid organ or hematopoietic stem cell transplantation…
View article: Invasive Central Nervous System Aspergillosis in a Patient Receiving Long-term Acalabrutinib Therapy
Invasive Central Nervous System Aspergillosis in a Patient Receiving Long-term Acalabrutinib Therapy Open
View article: Left Ventricular Assist Device: Review of Antimicrobial Prophylaxis Strategies and Incidence of Infections at a Tertiary Care Center 12-Year Experience
Left Ventricular Assist Device: Review of Antimicrobial Prophylaxis Strategies and Incidence of Infections at a Tertiary Care Center 12-Year Experience Open
Background Left ventricular assist devices (LVAD) have an associated infection rate of 13%–80% postimplant. An optimal strategy for surgical infection prophylaxis (SIP) at the time of implantation has not been well defined. We aimed to eva…
View article: Antifungal Susceptibility Pattern of Candida glabrata from a Referral Center and Reference Laboratory: 2012–2022
Antifungal Susceptibility Pattern of Candida glabrata from a Referral Center and Reference Laboratory: 2012–2022 Open
The prevalence of invasive candidiasis caused by non-Candida albicans has rapidly increased. Candida glabrata (Nakaseomyces glabrata) is an important pathogen associated with substantial mortality. Our study examined the antifungal tempora…
View article: Use of Novel Diagnostic Approaches to Identify Disseminated Ureaplasma urealyticum Infection Causing Hyperammonemia Syndrome After Heart-Kidney Transplant
Use of Novel Diagnostic Approaches to Identify Disseminated Ureaplasma urealyticum Infection Causing Hyperammonemia Syndrome After Heart-Kidney Transplant Open
View article: Supportive Care Management Recommendations for Mucocutaneous Manifestations of Monkeypox Infection
Supportive Care Management Recommendations for Mucocutaneous Manifestations of Monkeypox Infection Open
View article: <i>Leptotrichia</i> Bacteremia: 10-Year Retrospective Clinical Analysis and Antimicrobial Susceptibility Profiles
<i>Leptotrichia</i> Bacteremia: 10-Year Retrospective Clinical Analysis and Antimicrobial Susceptibility Profiles Open
Leptotrichia species are anaerobic, Gram-negative bacilli increasingly recognized as pathogens capable of causing invasive infections such as bloodstream infection (BSI), particularly among immunocompromised patients. However, there is a p…
View article: Comparing Complication Rates of Midline Catheter vs Peripherally Inserted Central Catheter. A Systematic Review and Meta-analysis
Comparing Complication Rates of Midline Catheter vs Peripherally Inserted Central Catheter. A Systematic Review and Meta-analysis Open
Background Peripherally inserted central catheters (PICCs) and midlines are commonly used devices for reliable vascular access. Infection and thrombosis are the main adverse effects of these catheters. We aimed to evaluate the relative ris…
View article: Karius With a Q: Role for Microbial Cell-Free DNA Next-Generation Sequencing in Diagnosis of Acute Q Fever
Karius With a Q: Role for Microbial Cell-Free DNA Next-Generation Sequencing in Diagnosis of Acute Q Fever Open
The diagnosis of Q fever can be challenging and a high index of suspicion is necessary. Within this case series, we highlight the utility of the microbial cell-free DNA next-generation sequencing or Karius Test in the timely diagnosis and …
View article: 755. Predictors of Mortality in Invasive Mold Infections Among Patients with Hematologic Malignancies and Hematopoietic Stem Cell Transplant Recipients
755. Predictors of Mortality in Invasive Mold Infections Among Patients with Hematologic Malignancies and Hematopoietic Stem Cell Transplant Recipients Open
Background Invasive Mold Infections (IMI) cause significant morbidity and mortality, particularly in patients with hematologic malignancies (HM) and hematopoietic stem cell transplant (HSCT) recipients. Although the risk has significantly …