Nishit Goradia
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View article: Master corepressor inactivation through multivalent SLiM-induced polymerization mediated by the oncogene suppressor RAI2
Master corepressor inactivation through multivalent SLiM-induced polymerization mediated by the oncogene suppressor RAI2 Open
While the elucidation of regulatory mechanisms of folded proteins is facilitated due to their amenability to high-resolution structural characterization, investigation of these mechanisms in disordered proteins is more challenging due to t…
View article: TBX2 controls a proproliferative gene expression program in melanoma
TBX2 controls a proproliferative gene expression program in melanoma Open
Senescence shapes embryonic development, plays a key role in aging, and is a critical barrier to cancer initiation, yet how senescence is regulated remains incompletely understood. TBX2 is an antisenescence T-box family transcription repre…
View article: Structural insights into heme binding to IL-36α proinflammatory cytokine
Structural insights into heme binding to IL-36α proinflammatory cytokine Open
Cytokines of the interleukin (IL)-1 family regulate immune and inflammatory responses. The recently discovered IL-36 family members are involved in psoriasis, rheumatoid arthritis, and pulmonary diseases. Here, we show that IL-36α interact…
View article: Structure determination of peptide-heme complexes
Structure determination of peptide-heme complexes Open
Heme has been traditionally viewed as a stable protein cofactor in hemoproteins. Only recently it is also being viewed as a signaling and regulatory molecule that binds temporarily to proteins and regulates their activation or inhibition. …