Nisi Zhang
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View article: Development of an in situ CAR-T cell protocol through optical and PSMA-targeted PET imaging
Development of an in situ CAR-T cell protocol through optical and PSMA-targeted PET imaging Open
In situ T cell transfection methods overcome the complexity and high costs associated with conventional chimeric antigen receptor (CAR)-T therapy. However, the in situ CAR-T cell approach operates within the patient’s complex immune enviro…
View article: Spatial transcriptomic analysis drives PET imaging of tight junction protein expression in pancreatic cancer theranostics
Spatial transcriptomic analysis drives PET imaging of tight junction protein expression in pancreatic cancer theranostics Open
View article: [Utilizing Sonodynamic Therapy-Induced Pyroptosis for Liver Cancer Therapy].
[Utilizing Sonodynamic Therapy-Induced Pyroptosis for Liver Cancer Therapy]. Open
Liver cancer is one of the leading causes of cancer-related deaths worldwide. However, all liver cancer treatment options currently available fail to achieve a complete cure. Recently, research on pyroptosis has attracted significant atten…
View article: Pyroptosis Induction with Nanosonosensitizer‐Augmented Sonodynamic Therapy Combined with PD‐L1 Blockade Boosts Efficacy against Liver Cancer
Pyroptosis Induction with Nanosonosensitizer‐Augmented Sonodynamic Therapy Combined with PD‐L1 Blockade Boosts Efficacy against Liver Cancer Open
Induction of pyroptosis can promote anti‐PD‐L1 therapeutic efficacy due to the release of pro‐inflammatory cytokines, but current approaches can cause off target toxicity. Herein, a phthalocyanine‐conjugated mesoporous silicate nanoparticl…
View article: Protocol for in vitro sonoporation validation using non-targeted microbubbles for human studies of ultrasound-mediated gene delivery
Protocol for in vitro sonoporation validation using non-targeted microbubbles for human studies of ultrasound-mediated gene delivery Open
Microbubbles are currently approved for diagnostic ultrasound imaging and are under evaluation in therapeutic protocols. Here, we present a protocol for in vitro sonoporation validation using non-targeted microbubbles for gene delivery. We…
View article: Sonogenetic control of multiplexed genome regulation and base editing
Sonogenetic control of multiplexed genome regulation and base editing Open
Manipulating gene expression in the host genome with high precision is crucial for controlling cellular function and behavior. Here, we present a precise, non-invasive, and tunable strategy for controlling the expression of multiple endoge…
View article: PET imaging of focused-ultrasound enhanced delivery of AAVs into the murine brain
PET imaging of focused-ultrasound enhanced delivery of AAVs into the murine brain Open
Rationale: Despite recent advances in the use of adeno-associated viruses (AAVs) as potential vehicles for genetic intervention of central and peripheral nervous system-associated disorders, gene therapy for the treatment of neuropa…
View article: Sonogenetic control of multiplexed genome regulation and base editing
Sonogenetic control of multiplexed genome regulation and base editing Open
The file contains the source data that was used for reporting the results in the manuscript "Sonogenetic control of multiplexed genome regulation and base editing"
View article: Multiomic analysis for optimization of combined focal and immunotherapy protocols in murine pancreatic cancer
Multiomic analysis for optimization of combined focal and immunotherapy protocols in murine pancreatic cancer Open
Background: Although combination immunotherapies incorporating local and systemic components have shown promising results in treating solid tumors, varied tumor microenvironments (TMEs) can impact immunotherapeutic efficacy. Meth…
View article: Synergies between therapeutic ultrasound, gene therapy and immunotherapy in cancer treatment
Synergies between therapeutic ultrasound, gene therapy and immunotherapy in cancer treatment Open
View article: Optimization of Microbubble‐Based DNA Vaccination with Low‐Frequency Ultrasound for Enhanced Cancer Immunotherapy
Optimization of Microbubble‐Based DNA Vaccination with Low‐Frequency Ultrasound for Enhanced Cancer Immunotherapy Open
Immunotherapy is an important cancer treatment strategy; nevertheless, the lack of robust immune cell infiltration in the tumor microenvironment remains a factor in limiting patient response rates. In vivo gene delivery protocols can ampli…
View article: Immune modulation resulting from MR-guided high intensity focused ultrasound in a model of murine breast cancer
Immune modulation resulting from MR-guided high intensity focused ultrasound in a model of murine breast cancer Open
View article: Low-frequency ultrasound-mediated cytokine transfection enhances T cell recruitment at local and distant tumor sites
Low-frequency ultrasound-mediated cytokine transfection enhances T cell recruitment at local and distant tumor sites Open
Robust cytotoxic T cell infiltration has proven to be difficult to achieve in solid tumors. We set out to develop a flexible protocol to efficiently transfect tumor and stromal cells to produce immune-activating cytokines, and thus enhance…
View article: Source data for paper entitled "Low-frequency ultrasound-mediated cytokine transfection enhances T cell recruitment at local and distant tumor sites"
Source data for paper entitled "Low-frequency ultrasound-mediated cytokine transfection enhances T cell recruitment at local and distant tumor sites" Open
This is the source data that was used to generate the Figures and Supplementary Figures in the PNAS paper entitled "Low-frequency ultrasound-mediated cytokine transfection enhances T cell recruitment at local and distant tumor sites".
View article: Harnessing platelets as functional vectors for contrast enhanced ultrasound imaging and fluorescence imaging
Harnessing platelets as functional vectors for contrast enhanced ultrasound imaging and fluorescence imaging Open
The recent progress in the development of highly biocompatible nanoplatforms mostly encompasses the use of biological excipients such as red blood cells, cancer cell membranes, and also platelets.
View article: Ultrasound contrast agent microbubbles with ultrahigh loading capacity of camptothecin and floxuridine for enhancing tumor accumulation and combined chemotherapeutic efficacy
Ultrasound contrast agent microbubbles with ultrahigh loading capacity of camptothecin and floxuridine for enhancing tumor accumulation and combined chemotherapeutic efficacy Open
Amphiphilic Janus camptothecin-floxuridine (CF) conjugate was synthesized for engineering CF microbubbles (CF MBs) with ultrahigh drug-loading contents. CF MBs exhibited excellent capability to enhance ultrasound (US) imaging for identifyi…
View article: Mechanisms of enhanced antiglioma efficacy of polysorbate 80‐modified paclitaxel‐loaded PLGA nanoparticles by focused ultrasound
Mechanisms of enhanced antiglioma efficacy of polysorbate 80‐modified paclitaxel‐loaded PLGA nanoparticles by focused ultrasound Open
The presence of blood‐brain barrier ( BBB ) greatly limits the availability of drugs and their efficacy against glioma. Focused ultrasound ( FUS ) can induce transient and local BBB opening for enhanced drug delivery. Here, we developed po…
View article: Advances in enhancing cancer immunotherapy by nanotechnology
Advances in enhancing cancer immunotherapy by nanotechnology Open
To date, the preliminary research for understanding the underlying cancer etiology has made great progress. However, due to the heterogeneity of cancer and the complexity of tumor microenvironment, as well as the evasion of tumor cells fro…
View article: Localized delivery of curcumin into brain with polysorbate 80-modified cerasomes by ultrasound-targeted microbubble destruction for improved Parkinson's disease therapy
Localized delivery of curcumin into brain with polysorbate 80-modified cerasomes by ultrasound-targeted microbubble destruction for improved Parkinson's disease therapy Open
Rationale: Treatment for Parkinson's disease (PD) is challenged by the presence of the blood-brain barrier (BBB) that significantly limits the effective drug concentration in a patient's brain for therapeutic response throughout var…
View article: Self-assembly of porphyrin-grafted lipid into nanoparticles encapsulating doxorubicin for synergistic chemo-photodynamic therapy and fluorescence imaging
Self-assembly of porphyrin-grafted lipid into nanoparticles encapsulating doxorubicin for synergistic chemo-photodynamic therapy and fluorescence imaging Open
The limited clinical efficacy of monotherapies in the clinic has urged the development of novel combination platforms. Taking advantage of light-triggered photodynamic treatment combined together with the controlled release of nanomedicine…
View article: Advances in equipment for tumor sonodynamic therapy
Advances in equipment for tumor sonodynamic therapy Open