Explanipedia

Sclerostin antibody corrects periodontal disease in type 2 diabetic mice Open

Hakan Türkkahraman, Shannan Flanagan, Tianli Zhu, Nisreen Akel, Silvia Marino , et al. · 2024

Type 2 diabetes (T2D) is on the rise worldwide and is associated with various complications in the oral cavity. Using an adult-onset diabetes preclinical model, we demonstrated profound periodontal alterations in T2D mice, including inflam…

Loss of chaperone‐mediated autophagy does not alter age‐related bone loss in male mice Open

James A. Hendrixson, A. Gordon James, Nisreen Akel, Dominique J. Laster, Julie Crawford , et al. · 2024

Chaperone‐mediated autophagy (CMA) is a lysosome‐dependent degradation pathway that eliminates proteins that are damaged, partially unfolded, or targeted for selective proteome remodeling. CMA contributes to several cellular processes, inc…

THU346 Repairing Skeletal Deterioration In Diabetes With Bone Anabolic Therapies Open

Silvia Marino, Nisreen Akel, Shenyang Li, Meloney Cregor, Betiana Perez , et al. · 2023

Disclosure: S. Marino: None. N. Akel: None. S. Li: None. M. Cregor: None. B. Perez: None. G. Troncoso: None. J. Meeks: None. S. Stuart: None. A. Sato: None. I. Nookaew: None. T. Bellido: None. Treatments for skeletal fragility in diabetes …

CRISPR interference provides increased cell type-specificity compared to the Cre-loxP system Open

Dominique J. Laster, Nisreen Akel, James A. Hendrixson, Alicen James, Julie Crawford , et al. · 2023

Cre-mediated recombination is frequently used for cell type-specific loss of function (LOF) studies. A major limitation of this system is recombination in unwanted cell types. CRISPR interference (CRISPRi) has been used effectively for glo…

Author Correction: Reversal of the diabetic bone signature with anabolic therapies in mice Open

Silvia Marino, Nisreen Akel, Shenyang Li, Meloney Cregor, Meghan Jones , et al. · 2023

Author Correction: Reversal of the diabetic bone signature with anabolic therapies in mice Open

Silvia Marino, Nisreen Akel, Shenyang Li, Meloney Cregor, Meghan Jones , et al. · 2023

Reversal of the diabetic bone signature with anabolic therapies in mice Open

Silvia Marino, Nisreen Akel, Shenyang Li, Meloney Cregor, Meghan Jones , et al. · 2023

The mechanisms underlying the bone disease induced by diabetes are complex and not fully understood; and antiresorptive agents, the current standard of care, do not restore the weakened bone architecture. Herein, we reveal the diabetic bon…

Loss of chaperone-mediated autophagy is associated with low vertebral cancellous bone mass Open

Nisreen Akel, Ryan S. MacLeod, Stuart B. Berryhill, Dominique J. Laster, Milena Dimori , et al. · 2022

Decoding the epitranscriptional landscape from native RNA sequences Open

Piroon Jenjaroenpun, Thidathip Wongsurawat, Taylor D. Wadley, Trudy M. Wassenaar, Jun Liu , et al. · 2020

Traditional epitranscriptomics relies on capturing a single RNA modification by antibody or chemical treatment, combined with short-read sequencing to identify its transcriptomic location. This approach is labor-intensive and may introduce…

Decoding the Epitranscriptional Landscape from Native RNA Sequences Open

Thidathip Wongsurawat, Piroon Jenjaroenpun, Trudy M. Wassenaar, Taylor D. Wadley, Visanu Wanchai , et al. · 2018

Sequencing of native RNA and corresponding cDNA was performed using Oxford Nanopore Technology. The % Error of Specific Bases (%ESB) was higher for native RNA than for cDNA, which enabled detection of ribonucleotide modification sites. Bas…

Sclerostin Antibody Treatment Stimulates Bone Formation to Normalize Bone Mass in Male Down Syndrome Mice Open

Diarra K Williams, Sean G. Parham, Eric M. Schryver, Nisreen Akel, Randal S. Shelton , et al. · 2017

Down syndrome (DS), characterized by trisomy of human chromosome 21, is associated with a variety of endocrine disorders as well as profound skeletal abnormalities. The low bone mass phenotype in DS is defined by low bone turnover due to d…

PTHrP(12-48) Modulates the Bone Marrow Microenvironment and Suppresses Human Osteoclast Differentiation and Lifespan Open

Archana Kamalakar, Charity L. Washam, Nisreen Akel, Bethany J. Allen, Diarra K Williams , et al. · 2017

Bone is a common site for metastasis in breast cancer patients and is associated with a series of complications that significantly compromise patient survival, partially due to the advanced stage of disease at the time of detection. Curren…

Activin A inhibits RANKL-mediated osteoclast formation, movement and function in murine bone marrow macrophage cultures Open

Tristan W. Fowler, Archana Kamalakar, Nisreen Akel, Richard C. Kurten, Larry J. Suva , et al. · 2015

The process of osteoclastic bone resorption is complex and regulated at multiple levels. The role of osteoclast (OCL) fusion and motility in bone resorption are unclear, with the movement of OCL on bone largely unexplored. RANKL is a poten…

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