Nitender Goyal
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View article: Thrombosis, Bleeding, and the Observational Effect of Early Therapeutic Anticoagulation on Survival in Critically Ill Patients With COVID-19
Thrombosis, Bleeding, and the Observational Effect of Early Therapeutic Anticoagulation on Survival in Critically Ill Patients With COVID-19 Open
BACKGROUND: Hypercoagulability may be a key mechanism of death in patients with coronavirus disease 2019 (COVID-19). OBJECTIVE: To evaluate the incidence of venous thromboembolism (VTE) and major bleeding in critically ill patients with CO…
View article: Embracing Generative Artificial Intelligence in Clinical Research and Beyond
Embracing Generative Artificial Intelligence in Clinical Research and Beyond Open
To explore threats and opportunities and to chart a path for safely navigating the rapid changes that generative artificial intelligence (AI) will bring to clinical research, the Duke Clinical Research Institute convened a multidisciplinar…
Tacrolimus to belatacept conversion in proteinuric kidney transplant recipients Open
Background Proteinuria is associated with worse allograft outcomes in kidney transplant recipients (KTRs) and treatment strategies are limited. We examined the outcomes of calcineurin inhibitor (CNI) to belatacept conversion in proteinuric…
RNA Interference With Zilebesiran for Mild to Moderate Hypertension Open
Importance Angiotensinogen is the most upstream precursor of the renin–angiotensin–aldosterone system, a key pathway in blood pressure (BP) regulation. Zilebesiran, an investigational RNA interference therapeutic, targets hepatic angiotens…
View article: Delayed Mortality Among Solid Organ Transplant Recipients Hospitalized for COVID-19
Delayed Mortality Among Solid Organ Transplant Recipients Hospitalized for COVID-19 Open
Background Most studies of solid organ transplant (SOT) recipients with coronavirus disease 2019 (COVID-19) focus on outcomes within 1 month of illness onset. Delayed mortality in SOT recipients hospitalized for COVID-19 has not been fully…
Kidney Recovery and Death in Critically Ill Patients With COVID-19–Associated Acute Kidney Injury Treated With Dialysis: The STOP-COVID Cohort Study Open
Lower baseline eGFR and reduced urine output at the time of KRT initiation are each strongly and independently associated with kidney nonrecovery among critically ill patients with COVID-19.
View article: In Reply to “Letter Regarding ‘Cardiac Outcomes in Isolated Heart and Simultaneous Kidney and Heart Transplants in the United States’”
In Reply to “Letter Regarding ‘Cardiac Outcomes in Isolated Heart and Simultaneous Kidney and Heart Transplants in the United States’” Open
We thank Dr. Okumura et al. for their interest in our study on outcomes in simultaneous kidney and heart transplants in the United States.1Agarwal K. Patel H. Agrawal N. Cardarelli F. Goyal N. Cardiac outcomes in isolated heart and simulta…
Machine Learning Prediction of Death in Critically Ill Patients With Coronavirus Disease 2019 Open
OBJECTIVES: Critically ill patients with coronavirus disease 2019 have variable mortality. Risk scores could improve care and be used for prognostic enrichment in trials. We aimed to compare machine learning algorithms and develop a simple…
Promoting Equity in Eligibility for Registration on the Kidney Transplantation Waiting List: Looking beyond eGFRcr Open
Racial disparities in access to kidney transplantation in the United States are well known, with non-Hispanic Blacks having 65% lower access to transplantation compared with non-Hispanic Whites in the first year after kidney failure with r…
View article: Thrombosis, Bleeding, and the Observational Effect of Early Therapeutic Anticoagulation on Survival in Critically Ill Patients With COVID-19
Thrombosis, Bleeding, and the Observational Effect of Early Therapeutic Anticoagulation on Survival in Critically Ill Patients With COVID-19 Open
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View article: AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19
AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19 Open
Significance Statement Although AKI is an important sequela of coronavirus disease 2019 (COVID-19), data on AKI treated with RRT (AKI-RRT) in patients with COVID-19 are limited. In a multicenter cohort study of 3099 critically ill adults w…
Expecting the unexpected: COVID‐19 in Kidney Transplant Recipients within United Network for Organ Sharing Region 1 Open
Dear Editors, There are numerous case reports and a handful of single [1-5]-center studies reporting on COVID-19 in kidney transplant recipients. Most reports arise from the epicenters of where the SARS-CoV-2 virus was first detected such …
View article: Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US
Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US Open
This study identified demographic, clinical, and hospital-level risk factors that may be associated with death in critically ill patients with COVID-19 and can facilitate the identification of medications and supportive therapies to improv…
The Rate of Hospitalizations and Intensive Care Admissions in Boston Children Hospital Open
Much remains unknown about the overall impact of COVID-19 on the pediatric population because of the relative low incidence of symptomatic pediatric cases compared to other age groups. Recent anecdotal reports of rare and unique illnesses …
Comparison between India, USA and China on the Basis of Rigidity of Public Health Measures with Case Count and Mortality Rate during COVID-19 Open
The COVID-19 Pandemic has been governed by various policies across the world, with corresponding public health measures varying in rigidity. Does this influence the course of the illness within each nation? This research presents an analys…
1765. BK Polyomavirus Reactivation Outcomes After Renal Transplantation in Association With Adherence to a Standardized BK Polyomavirus Screening Protocol: A Multi-Center Collaboration Open
Background Reactivation of BK polyomavirus (BKPyV) due to immunosuppression after renal transplantation can lead to allograft nephropathy (BKAN) or even allograft loss. Many transplant centers implement screening protocols in an attempt to…
The Affordable Care Act, Kidney Transplant Access, and Kidney Disease Care in the United States Open
Disparities in access to health care, including in access to kidney transplantation, are widespread in the United States (1). Although the Medicare ESRD program is one of the few examples of a single-payer system in the United States, most…