Nitin K. Singh
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View article: Correction: Genomic insights into novel extremotolerant bacteria isolated from the NASA Phoenix mission spacecraft assembly cleanrooms
Correction: Genomic insights into novel extremotolerant bacteria isolated from the NASA Phoenix mission spacecraft assembly cleanrooms Open
View article: Survival of NASA-cleanroom microbial isolates under simulated space and Martian conditions
Survival of NASA-cleanroom microbial isolates under simulated space and Martian conditions Open
Planetary protection hinges on understanding microbial survival following sterilization procedures, the stressors of space travel, and exposure to extraterrestrial environmental conditions. This study identified 23 fungal strains isolated …
View article: Genomic characterization of Microbacterium meiriae sp. nov., a novel bacterium isolated from the International Space Station
Genomic characterization of Microbacterium meiriae sp. nov., a novel bacterium isolated from the International Space Station Open
During the microbial surveillance of the International Space Station (ISS) in April 2018, four Gram-stain positive bacterial strains, designated as F6_8S_P_2BT, F6_8S_P_3A, F6_8S_P_3B and F6_8S_P_3C, belonging to the genus Micro…
View article: Plasmidome, resistome, and virulence-associated genes characterization of <i>Acinetobacter johnsonii</i> in NASA cleanrooms and a clinical setting
Plasmidome, resistome, and virulence-associated genes characterization of <i>Acinetobacter johnsonii</i> in NASA cleanrooms and a clinical setting Open
Evidence shows persistence of non-spore-forming Acinetobacter johnsonii in high-stakes controlled and nutrient-limited environments. This study aims to explore the mechanisms underpinning such adaptability through a comprehensive genomic a…
View article: A Comprehensive Study of Financial Modelling for JP Morgan chase
A Comprehensive Study of Financial Modelling for JP Morgan chase Open
This project presents a comprehensive study of financial modelling techniques as applied to JPMorgan Chase, one of the largest and most influential financial institutions in the world. Financial modelling is a critical tool used for foreca…
View article: Exploring the interactions between mining and climate change: a bibliometric analysis
Exploring the interactions between mining and climate change: a bibliometric analysis Open
View article: Risk factors associated with Indian type 2 diabetes patients with chronic kidney disease: CITE study, a cross-sectional, real-world, observational study
Risk factors associated with Indian type 2 diabetes patients with chronic kidney disease: CITE study, a cross-sectional, real-world, observational study Open
The CITE study highlights the prevalence of CKD (32%) in Indian patients with T2DM and identifies clinical and laboratory factors associated with CKD, including age ≥ 60 years, T2DM duration, SBP, HbA1c, tobacco use, non-vegetarian diet, a…
View article: EVALUATION OF ORIGORAN AS A NATURAL ALTERNATIVE TO ANTIBIOTIC GROWTH PROMOTERS IN BROILER CHICKENS
EVALUATION OF ORIGORAN AS A NATURAL ALTERNATIVE TO ANTIBIOTIC GROWTH PROMOTERS IN BROILER CHICKENS Open
The overuse of antibiotic growth promoters (AGPs) in poultry production has raised significant public health concerns, leading to a global push toward safer, natural alternatives. This study aimed to evaluate the efficacy of ORIGORAN, a ph…
View article: Genomic insights into novel extremotolerant bacteria isolated from the NASA Phoenix mission spacecraft assembly cleanrooms
Genomic insights into novel extremotolerant bacteria isolated from the NASA Phoenix mission spacecraft assembly cleanrooms Open
Background Human-designed oligotrophic environments, such as cleanrooms, harbor unique microbial communities shaped by selective pressures like temperature, humidity, nutrient availability, cleaning reagents, and radiation. Maintaining the…
View article: Unveiling Hidden Microbial Diversity in Mars 2020 Mission Assembly Cleanrooms with Molecular Insights into the Persistent and Perseverance of Novel Species Defying Metagenome Sequencing
Unveiling Hidden Microbial Diversity in Mars 2020 Mission Assembly Cleanrooms with Molecular Insights into the Persistent and Perseverance of Novel Species Defying Metagenome Sequencing Open
NASA cleanrooms, where space mission components are assembled, maintain stringent cleaning protocols and nutrient-poor environments, resulting in low yet persistent microbial loads. Although these oligotrophic extremophiles are reported in…
View article: <b><span>Synthesis and Application of Coconut Shell Derived Activated Carbon </span></b>
<b><span>Synthesis and Application of Coconut Shell Derived Activated Carbon </span></b> Open
View article: <b><span>Performance Evaluation and Improvement Investigations on A Moving Bed Biofilm Reactor</span></b>
<b><span>Performance Evaluation and Improvement Investigations on A Moving Bed Biofilm Reactor</span></b> Open
View article: <i>Neobacillus driksii</i> sp. nov. isolated from a Mars 2020 spacecraft assembly facility and genomic potential for lasso peptide production in <i>Neobacillus</i>
<i>Neobacillus driksii</i> sp. nov. isolated from a Mars 2020 spacecraft assembly facility and genomic potential for lasso peptide production in <i>Neobacillus</i> Open
During microbial surveillance of the Mars 2020 spacecraft assembly facility, two novel bacterial strains, potentially capable of producing lasso peptides, were identified. Characterization using a polyphasic taxonomic approach, whole-genom…
View article: Adaptation to space conditions of novel bacterial species isolated from the International Space Station revealed by functional gene annotations and comparative genome analysis
Adaptation to space conditions of novel bacterial species isolated from the International Space Station revealed by functional gene annotations and comparative genome analysis Open
Our findings indicate that the microorganisms isolated from ISS we studied have adapted to life in space. Evidence such as mechanosensitive channel proteins, increased DNA repair activity, as well as metallopeptidases and novel S-layer oxi…
View article: Spaceflight alters host-gut microbiota interactions
Spaceflight alters host-gut microbiota interactions Open
The ISS rodent habitat has provided crucial insights into the impact of spaceflight on mammals, inducing symptoms characteristic of liver disease, insulin resistance, osteopenia, and myopathy. Although these physiological responses can inv…
View article: Spaceflight alters host-gut microbiota interactions
Spaceflight alters host-gut microbiota interactions Open
The rodent habitat on the International Space Station has provided crucial insights into the impact of spaceflight on mammals, inducing symptoms characteristic of liver disease, insulin resistance, osteopenia, and myopathy. Although these …
View article: Genomic and morphological characterization of Knufia obscura isolated from the Mars 2020 spacecraft assembly facility
Genomic and morphological characterization of Knufia obscura isolated from the Mars 2020 spacecraft assembly facility Open
Members of the family Trichomeriaceae, belonging to the Chaetothyriales order and the Ascomycota phylum, are known for their capability to inhabit hostile environments characterized by extreme temperatures, oligotrophic conditions, drought…
View article: Whole-genome sequencing of <i>Paenibacillus phoenicis</i> isolated from the Phoenix Mars Lander spacecraft assembly facility
Whole-genome sequencing of <i>Paenibacillus phoenicis</i> isolated from the Phoenix Mars Lander spacecraft assembly facility Open
The genome of Paenibacillus phoenicis, a spore-forming bacterium isolated from the spacecraft assembly facility of the Phoenix mission, was generated via hybrid assembly by merging short and long reads. Examining this genome may shed light…
View article: Genomic, functional, and metabolic enhancements in multidrug-resistant Enterobacter bugandensis facilitating its persistence and succession in the International Space Station
Genomic, functional, and metabolic enhancements in multidrug-resistant Enterobacter bugandensis facilitating its persistence and succession in the International Space Station Open
View article: Novel spore-forming species exhibiting intrinsic resistance to third- and fourth-generation cephalosporins and description of <i>Tigheibacillus jepli</i> gen. nov., sp. nov.
Novel spore-forming species exhibiting intrinsic resistance to third- and fourth-generation cephalosporins and description of <i>Tigheibacillus jepli</i> gen. nov., sp. nov. Open
A comprehensive microbial surveillance was conducted at NASA’s Mars 2020 spacecraft assembly facility (SAF), where whole-genome sequencing (WGS) of 110 bacterial strains was performed. One isolate, designated 179-BFC-A-HS T , exhibited les…
View article: Planetary Protection Knowledge Gap Closure Enabling Crewed Missions to Mars
Planetary Protection Knowledge Gap Closure Enabling Crewed Missions to Mars Open
As focus for exploration of Mars transitions from current robotic explorers to development of crewed missions, it remains important to protect the integrity of scientific investigations at Mars, as well as protect the Earth's biosphere fro…
View article: Assessing microbial diversity in Yellowstone National Park hot springs using a field deployable automated nucleic acid extraction system
Assessing microbial diversity in Yellowstone National Park hot springs using a field deployable automated nucleic acid extraction system Open
Microbial diversity estimation involves extracting nucleic acids from intricate sample matrices. Preparing nucleic acid samples is time-consuming, necessitating effective cell lysis and obtaining pure, inhibitor-free nucleic acid purificat…
View article: The efficacy of clove oil to manage Varroa destructor and Apocephalus borealis, in Apis mellifera L. colony
The efficacy of clove oil to manage Varroa destructor and Apocephalus borealis, in Apis mellifera L. colony Open
Clove oil is a natural, eco-friendly, and highly effective odorant for triggering hygienic behavior in the colonies of Apis mellifera. Bees with highly hygienic behavior can quickly remove Varroa destructors and other enemies of bee hives.…
View article: Genomic analysis reveals the presence of emerging pathogenic <i>Klebsiella</i> lineages aboard the International Space Station
Genomic analysis reveals the presence of emerging pathogenic <i>Klebsiella</i> lineages aboard the International Space Station Open
Klebsiella species, such as Klebsiella pneumoniae , Klebsiella aerogenes , and Klebsiella quasipneumoniae , are opportunistic pathogens that commonly cause infections in humans. Hypervirulent Klebsiella pneumoniae (hvKP) is a subgroup of K…
View article: Phylogenomics, phenotypic, and functional traits of five novel (Earth-derived) bacterial species isolated from the International Space Station and their prevalence in metagenomes
Phylogenomics, phenotypic, and functional traits of five novel (Earth-derived) bacterial species isolated from the International Space Station and their prevalence in metagenomes Open
View article: Genomic and morphological characterization of Knufia obscura isolated from the Mars 2020 spacecraft assembly facility
Genomic and morphological characterization of Knufia obscura isolated from the Mars 2020 spacecraft assembly facility Open
Members of the family Trichomeriaceae, belonging to the Chaetothyriales order and the Ascomycota phylum, are known for their capability to inhabit hostile environments characterized by extreme temperatures, nutrient scarcity (oligotrophic …
View article: Adaptation to space conditions of novel bacterial species isolated from the International Space Station revealed by functional gene annotations and comparative genome analysis
Adaptation to space conditions of novel bacterial species isolated from the International Space Station revealed by functional gene annotations and comparative genome analysis Open
Background The extreme environment of the International Space Station (ISS) puts selective pressure on microorganisms unintentionally introduced during its 20+ years of service as a low-orbit science platform and human habitat. Such pressu…
View article: Draft genome sequencing of <i>Naganishia</i> species isolated from the polar environments
Draft genome sequencing of <i>Naganishia</i> species isolated from the polar environments Open
The draft genomes of five Naganishia strains were sequenced using MinION and annotated using Funannotate pipeline. Phylogenetic and genomic analyses were performed to provide their genetic relationships, diversity, and potential functional…
View article: Genomic, Functional, and Metabolic Enhancements in Multidrug-Resistant<i>Enterobacter bugandensis</i>Facilitating its Persistence and Succession in the International Space Station
Genomic, Functional, and Metabolic Enhancements in Multidrug-Resistant<i>Enterobacter bugandensis</i>Facilitating its Persistence and Succession in the International Space Station Open
Background The International Space Station (ISS) stands as a testament to human achievement in space exploration. Despite its highly controlled environment, characterised by microgravity, increased CO 2 levels, and elevated solar radiation…
View article: Genomic characterization and radiation tolerance of Naganishia kalamii sp. nov. and Cystobasidium onofrii sp. nov. from Mars 2020 mission assembly facilities
Genomic characterization and radiation tolerance of Naganishia kalamii sp. nov. and Cystobasidium onofrii sp. nov. from Mars 2020 mission assembly facilities Open
During the construction and assembly of the Mars 2020 mission components at two different NASA cleanrooms, several fungal strains were isolated. Based on their colony morphology, two strains that showed yeast-like appearance were further c…