Explanipedia

Leucine Zipper 4 Autoantibody–Associated Myeloneuropathy With Multiple Cranial Neuropathies and Longitudinally Extensive Tractopathy Open

Kimberly A. DiMauro, Nitin Manohar, Albert Aboseif, Chintan Shah, Justin Abbatemarco · 2025

Dopamine Loops and Player Retention: A Study on Reinforcement in Free-to-Play Games Open

Sarvajith Kumar J N, Nitin Manohar · 2025

Free-to-play (F2P) games are ruling the gaming world and use dopamine-driven reinforcement mechanisms to increase player retention and monetization. This paper aims to explore how random reward systems, time-locked progression, artificial …

Adjunctive Benefit of High-Field 3 Tesla MRI Guidance in Endoscopic Transsphenoidal Resection of Pituitary Adenoma Open

Kartik Manoj Multani, Anandh Balasubramaniam, Boyina Jagadeshwar Rajesh, Krishna Kumar Govindarajan, Nitin Manohar , et al. · 2022

Introduction Pituitary adenomas (PAs) although benign, are difficult to resect intracranial tumors and their residues are associated with morbidity and reduced quality of life. Thus, gross total resection (GTR) is the goal for all PAs. Rol…

Role of Asleep Surgery for Supplementary Motor Area Tumors Open

Krishna Kumar G., Chandrasekhar Chigurupalli, Anandh Balasubramaniam, B. J. Rajesh, Nitin Manohar · 2022

Background The supplementary motor area (SMA) is involved in planning of voluntary motor activities. Tumors in SMA usually present with seizures and, rarely, motor deficits. Postoperatively, these patients may develop SMA syndrome. Patient…

Intraoperative electrophysiological principles in neurooncological practice Open

Krishna Kumar Govindarajan, K. Pradeep, B. J. Rajesh, Vishwanath S. Bhaire, Nitin Manohar , et al. · 2021

Intraoperative neurophysiological monitoring (IOMN) is an important adjunct in modern day neurosurgical practice. There has been a paradigm shift from functional preservation to maximal safe or total excision of a tumor along with function…

Unilateral External Anal Sphincter MEP Monitoring in a Case of Conus Medullaris Tumor Open

Nitin Manohar, Astha Palan, S T Manjunath, Ravi Manchala · 2021

The use of intraoperative neurophysiological monitoring is a helpful tool during surgeries of conus medullaris tumors and helps in reducing the risk of post-operative functional compromise like paraparesis, sensory deficits, or urological …

Intraoperative MRI in Brain Tumor Surgeries Open

Ganesh K. Kumar, Anandh Balasubramaniam, K. Pradeep, Nitin Manohar · 2021

Intraoperative MRI (ioMRI) has evolved since it used in 1991. ioMRI has been effective tool not only in glioma surgeries but also in other neurosurgical procedures. It provides real time information with high quality resolution and it is n…

Indian Society of Neuroanaesthesiology and Critical Care (ISNACC) Position Statement and Advisory for the Practice of Neuroanesthesia during COVID-19 Pandemic Open

Kiran Jangra, Nitin Manohar, Prasanna Udupi Bidkar, Ponniah Vanamoorthy, Devendra Gupta , et al. · 2020

The coronavirus disease 2019 (COVID-19) is a major health emergency in today’s time. In December 2019, a cluster of pneumonia cases in Wuhan, China was attributed to a novel coronavirus. The World Health Organization declared it as a pande…

A Prospective Randomized Controlled Study to Analyze the Efficacy of Scalp Block in Providing Analgesia for Supratentorial Craniotomies Using Surgical Pleth Index, Response Entropy, and Hemodynamics Open

Manchala R. Kumar, Nitin Manohar, Astha Palan, Sumana Manjunath · 2020

Background: Supplementing general anesthesia with regional technique has markedly improved intraoperative hemodynamics and intraoperative analgesia. We compared the effects of scalp block (study group) and no scalp block (control group) on…

Thermal Injuries during Intraoperative Magnetic Resonance Imaging: Mechanisms and Prevention Open

Nitin Manohar, Astha Palan, Harsh Deora, Boyina Jagadishwar Rajesh, Anand Balasubramanium , et al. · 2019

Background Thermal injuries in a patient undergoing magnetic resonance imaging (MRI) are rare; more so, when the patient in question is being operated upon. We attempt to elucidate the various factors that may predispose to such an unfortu…

A0035 Effect of Scalp Block and Ultrasound-Guided Transverse Abdominis Plane Block on Intraoperative Hemodynamics and Perioperative Analgesia in Abdominal Bone Flap Cranioplasties: A Prospective, Randomized, Double-Blinded Study Open

Mritunjay Kumar, Nitin Manohar, Astha Palan, K. Pradeep · 2019

Background: Regional techniques provide good perioperative analgesia and stable intraoperative hemodynamics but sparsely used in neuroanesthesia. This study assessed the effect of scalp block and ultrasound-guided transverse abdominis plan…

A0037 High-Field 3T Intraoperative Magnetic Resonance Imaging in Neurosurgery: Single-Center Experience of 100 Cases Open

Astha Palan, Nitin Manohar, Ravi Manchala, Manjunath Seeresandra Thammaiah · 2019

Introduction: Intraoperative MRI (iMRI) is an upcoming tool in this modern era of neurosurgery, but it poses specific challenges.

A0036 Intraoperative Motor Evoked Potentials in a Pregnant Patient Open

Astha Palan, Nitin Manohar · 2019

Background: Intraoperative neurophysiological monitoring (IONM) is used to monitor the integrity of neuronal pathways and is necessary in neurosurgical procedures to prevent postoperative deficits. But its use and safety in pregnant cases …

Monitoring intraoperative motor-evoked potentials in a pregnant patient Open

Astha Palan, Nitin Manohar, RaviKumar Manchala, S T Manjunath · 2019

Intraoperative neurophysiological monitoring (IONM) is used to monitor the integrity of neuronal pathways and is necessary in neurosurgical procedures to prevent the occurrence of new onset neurodeficits. But its use and safety in pregnant…

Intraoperative Magnetic Resonance Imaging with Evoked Potential Monitoring: Tailored Method of Scalp Corkscrew Electrode Placement to Reduce Image Artifacts Open

Nitin Manohar, Astha Palan, Devi Prasad Mohapatra, Keerthi Rao, Deepti Srinivas , et al. · 2019

Intraoperative magnetic resonance imaging (IMRI) is an essential tool in the age of image-guided neurosurgery for distinguishing between abnormal and normal brain tissues, minimizing tumor residue, and guiding accurate tumor resection in b…

Propriospinal myoclonus following spinal anesthesia: A rare complication Open

Bharath Srinivasaiah, Vijayanand Budi, Nitin Manohar, Gajanan Fultambkar · 2019

Madam, Spinal myoclonus are sudden, brief, shock-like involuntary movements that originate in the spinal cord.[12] It is a rare complication following spinal cord stimulation induced by drugs administered via intrathecal or epidural routes…

Haemodynamic changes during prone positioning in anaesthetised chronic cervical myelopathy patients Open

Muthuchellappan Radhakrishnan, Nitin Manohar, VenkatapuraJ Ramesh, Dhritiman Chakraborti · 2019

Cervical myelopathy patients experienced hypotension with preserved cardiac output in prone position due to a reduction in total peripheral resistance. Hypotension correlated with the number of levels of spinal cord compression.

Anaesthetic management of a case of Haberland's syndrome (encephalocraniocutaneous lipomatosis) Open

Harsh Deora, KeerthiS Rao, Gita Nath, Nitin Manohar · 2019

While the Haberland syndrome was first reported in 1970, the anaesthetic management of this rare cohort of patients has not been described. With only 54 such cases reported, describing primarily the unilateral cutaneous, ocular, and neurol…

Setting Up Workflow of an Intraoperative MRI Unit: A Single-Centre Experience of First 53 Cases Open

Nitin Manohar, Devi Prasad Mohapatra, Anandh Balasubramaniam, Keerthi Rao, Deepti Srinivas , et al. · 2018

Background Setting up of a new “nearby” operation room type intraoperative magnetic resonance imaging (iMRI) unit poses a unique set of challenges to the operating team. We describe here an account of our experiences and a step by step pro…

Novel Use of Transcranial MEP and SSEP in a Case of Sciatic Nerve Tumor Open

Nitin Manohar, Anand Balasubramanium · 2018

Keywords sciatic nerve tumor - transcranial motor evoked potentials - somatosensory evoked potentials

A comparative study of midazolam and target-controlled propofol infusion in the treatment of refractory status epilepticus Open

Dheeraj Masapu, K. N. Gopala Krishna, Sinha Sanjib, Dhrithiman Chakrabarti, Ravindranadh Chowdary Mundlamuri , et al. · 2018

The choice of anesthetic agent does not seem to affect the overall outcome in RSE and SRSE. Target-controlled propofol infusion was found to be equal in its efficacy to midazolam for the treatment of RSE. High mortality might be due to SRS…

Prone Position Ventilation in a Patient of Severe ARDS with Raised Intracranial Pressure Open

Hemanth Waghmare, M. M. Harish, Durgesh Satalkar, Pavan K. Vala, Mahendra Bagul , et al. · 2018

Keywords acute respiratory distress syndrome - neurotrauma - prone position ventilation - intracranial pressure

Suppression of Motor Evoked Potentials with Low MAC Sevoflurane Open

Sagar Bandishte, Nitin Manohar, B. Vijaykumar, Anand Balasubramanium · 2018

Keywords motor evoked potentials - spine surgeries - neuromonitoring - inhalational anesthetics

Effect of adjunctive dexmedetomidine on anesthesia and analgesia requirement and recovery characteristics during Bispectral Index-guided anesthesia for cerebello-pontine angle surgeries: A randomized clinical trial Open

Druvadeep Srinivas, Dhritiman Chakrabarti, Kamath Sriganesh, KR Madhusudan Reddy, Nitin Manohar , et al. · 2018

Dexmedetomidine-fentanyl-propofol anesthesia compares favorably with fentanyl-propofol anesthesia during CPA neurosurgical procedures with regard to anesthesia recovery times, but with lower intraoperative opioid and hypnotic utilization r…

GPi-Targeted DBS Placement using Optic Tract Stimulated VEP and Corticospinal Tract Stimulation in a Case of Severe Primary Dystonia Open

Nitin Manohar · 2018

Introduction:Optical tract stimulated visual evoked potential (VEP) is useful during deep brain stimulation (DBS) in the globus pallidus internum (Gpi) for the treatment of primary dystonia.Recordings of cortical VEPs obtained after stimul…

Intraoperative Seizures Detected as Increased Bispectral Index Values during Posterior Fossa Surgeries Open

Deepti Srinivas, Radhakrishnan Muthuchellappan, Dhritiman Chakrabarti, Manjunatha Lakshmegowda, Nitin Manohar · 2018

We present a case series of four cerebellopontine angle surgeries with intraoperative detection seizure activity. The cases discussed follow the uniform anesthetic protocol of maintenance with infusion of propofol, fentanyl and dexmedetomi…

Setting Up an Intraoperative MRI Suite: Our Experience Open

Nitin Manohar, Anand Balasubramanium, B. Vijay Kumar, Dhritiman Chakrabarti, Basavaraj Rajesh , et al. · 2018

belonged to the age group of 0 to 12 years.Of these, 52 patients presented with headache and 40 had vomiting.Blurring of vision was seen in 22 patients.Most common midline posterior fossa tumor was medulloblastoma.Postoperative hydrocephal…

Hemodynamic changes in cervical myelopathy with prone position using non invasive cardiac output monitor Open

Nitin Manohar, V. Ramesh, Radhakrishnan Muthuchellappan · 2017

Introduction: Prone positioning under anaesthesia alters cardiovascular physiology and cervical myelopathy patients are known to have autonomic dysfunction thus putting them at higher risk of developing hemodynamic changes when proned and …

Pharmacological Studies on Drug-Drug Interactions between Antidiabetic Drug (Glibenclamide) and Selective Anti-HIV Drug (Lamivudine) in Rats and Rabbits Open

Guru Bhavimani, Nitin Manohar · 2017

The studies were conducted in normal and diabetic rats, and in normal rabbits to find out the influence of lamivudine on pharmacodynamics of glibenclamide. Rats were divided into four groups each containing six. Group-I: treated with thera…

Bispectral index and haemodynamic alterations during surgical decompression in head injury patients Open

Nitin Manohar, Radhakrishnan Muthuchellappan, Dhritiman Chakrabarti, S. Deepti, Dheeraj Masapu · 2016

Introduction: Poor neurological status in traumatic brain injury (TBI) patients can be due to raised intracranial pressure or underlying brain parenchymal injury or a combination. Surgical decompression would improve the neurological condi…

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