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View article: Donor-derived cell-free DNA significantly improves rejection yield in kidney transplant biopsies
Donor-derived cell-free DNA significantly improves rejection yield in kidney transplant biopsies Open
View article: Post–COVID-19 cardiovascular disease risk in kidney transplant recipients
Post–COVID-19 cardiovascular disease risk in kidney transplant recipients Open
View article: Outcomes of SOT Recipients With COVID-19 in Different Eras of COVID-19 Therapeutics
Outcomes of SOT Recipients With COVID-19 in Different Eras of COVID-19 Therapeutics Open
BACKGROUND: Few reports have focused on newer coronavirus disease 2019 (COVID-19) therapies (remdesivir, dexamethasone, and convalescent plasma) in solid organ transplant recipients; concerns had been raised regarding possible adverse impa…
View article: Enhancing knowledge of vascular pythiosis: Impact of a self-paced online course among Thai learners
Enhancing knowledge of vascular pythiosis: Impact of a self-paced online course among Thai learners Open
Background Pythiosis caused by Pythium insidiosum , is a rare but deadly infectious disease that is often underrecognized. The disease has high morbidity and mortality rates, particularly in vascular forms where surgical resection is neces…
View article: Pythium insidiosum-antigen enhances neutrophil-mediated killing of zoospores
Pythium insidiosum-antigen enhances neutrophil-mediated killing of zoospores Open
Pythium insidiosum-antigen (PIA) immunotherapy has been used to treat human pythiosis. This study compared PIA-stimulated and unstimulated neutrophils on zoospore viability of P. insidiosum strains. We cultured and collected zoospores of 6…
View article: P-2286. Invasive Fungal Infections in Patients Treated with Bruton Tyrosine Kinase Inhibitors: a Systematic Review and Meta-Analysis
P-2286. Invasive Fungal Infections in Patients Treated with Bruton Tyrosine Kinase Inhibitors: a Systematic Review and Meta-Analysis Open
Background Controversy surrounds the true incidence of invasive fungal infections (IFIs) in patients on Bruton tyrosine kinase inhibitors (BTKIs) due to incomplete epidemiological data. This systematic review and meta-analysis evaluated th…
View article: P-1033. Post-transplant Outcomes in Kidney Transplant Recipients with Invasive Fungal Infections Prior vs. After the Emergence of SARS-CoV2
P-1033. Post-transplant Outcomes in Kidney Transplant Recipients with Invasive Fungal Infections Prior vs. After the Emergence of SARS-CoV2 Open
Background Invasive fungal infections (IFIs) are a serious complication in kidney transplant recipients (KTRs), leading to increased mortality and graft failure. Given changes in care associated with pandemic conditions and potential compo…
View article: Multiple dimensions of neurological injury in a liver transplant recipient with cryptococcal meningitis
Multiple dimensions of neurological injury in a liver transplant recipient with cryptococcal meningitis Open
Background Meningitis due to Cryptococcus neoformans continues to cause substantial morbidity and mortality in victims of this infection. Worldwide, immunosuppression due to uncontrolled HIV disease is the main risk factor. In the United S…
View article: Functional characterization of macrophages and change of Th1/Th2 balance in patients with pythiosis after Pythium insidiosum antigen immunotherapy
Functional characterization of macrophages and change of Th1/Th2 balance in patients with pythiosis after Pythium insidiosum antigen immunotherapy Open
View article: Candidemia Following Severe <scp>COVID</scp>‐19 in Hospitalised and Critical Ill Patients: A Systematic Review and Meta‐Analysis
Candidemia Following Severe <span>COVID</span>‐19 in Hospitalised and Critical Ill Patients: A Systematic Review and Meta‐Analysis Open
Rationale The epidemiology and clinical impact of COVID‐19‐associated candidemia (CAC) remained uncertain, leaving gaps in understanding its prevalence, risk factors and outcomes. Methods A systematic review and meta‐analysis were conducte…
View article: Needs assessment of a pythiosis continuing professional development program
Needs assessment of a pythiosis continuing professional development program Open
Background Pythiosis is a rare disease with high mortality, with over 94% of cases reported from Thailand and India. Prompt diagnosis and surgery improves patient outcomes. Therefore, continuing professional development (CPD) is essential …
View article: <i>Ex vivo</i> observation of <i>Pythium insidiosum</i> -antigen treated neutrophils on three <i>Pythium insidiosum</i> strains isolated from vascular pythiosis patients
<i>Ex vivo</i> observation of <i>Pythium insidiosum</i> -antigen treated neutrophils on three <i>Pythium insidiosum</i> strains isolated from vascular pythiosis patients Open
The mechanisms of Pythium insidiosum-antigen (PIA) immunotherapy activating a patient's immune system are unknown. We evaluated the interleukin-8 (IL-8) serum levels during P. insidiosum infection and after vaccination with P…
View article: 615. A Prospective Cohort Study to Evaluate Performance of Myco<i>MEIA – Aspergillus</i>: A New Urine Diagnostic for Aspergillosis
615. A Prospective Cohort Study to Evaluate Performance of Myco<i>MEIA – Aspergillus</i>: A New Urine Diagnostic for Aspergillosis Open
Background The MycoMEIA urine diagnostic was developed as an enzyme immunoassay, by Johns Hopkins (JH) and Pearl Diagnostics. In a retrospective study of 310 people, the assay was 90.5% (95% CI 70-99) sensitive and 89.2% (95% CI 82-94) spe…
View article: 374. A Multicenter Open-Label Single-Arm Clinical Trial of Combination Therapy of Surgery, Itraconazole, Doxycycline, and Azithromycin for Vascular Pythiosis
374. A Multicenter Open-Label Single-Arm Clinical Trial of Combination Therapy of Surgery, Itraconazole, Doxycycline, and Azithromycin for Vascular Pythiosis Open
Background Vascular pythiosis, caused by Pythium insidiosum, is a neglected, life-threatening condition which carried a 100% mortality rate, within 3 months, among patients with residual disease after surgery, regardless of antifungal trea…
View article: Progressive disseminated histoplasmosis: The experience in one non-endemic medical center
Progressive disseminated histoplasmosis: The experience in one non-endemic medical center Open
Histoplasmosis, the most common endemic mycosis in North America, presents in a myriad of ways, spanning the spectrum from self-limiting pneumonia to progressive disseminated histoplasmosis (PDH). Toward better describing contemporary hist…
View article: Attenuated immunogenicity of SARS-CoV-2 vaccines and risk factors in stem cell transplant recipients: a meta-analysis
Attenuated immunogenicity of SARS-CoV-2 vaccines and risk factors in stem cell transplant recipients: a meta-analysis Open
Immunogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination is diminished in hematopoietic stem cell transplant (HSCT) recipients. To summarize current evidence and identify risk factors for attenuated respon…
View article: Coronavirus Disease 2019–Associated Pulmonary Aspergillosis: A Noninvasive Screening Model for Additional Diagnostics
Coronavirus Disease 2019–Associated Pulmonary Aspergillosis: A Noninvasive Screening Model for Additional Diagnostics Open
Background Coronavirus disease 2019 (COVID-19)–associated pulmonary aspergillosis (CAPA) is likely underdiagnosed, and current diagnostic tools are either invasive or insensitive. Methods A retrospective study of mechanically ventilated pa…
View article: Prevalence of Ocular Candidiasis and <i>Candida</i> Endophthalmitis in Patients With Candidemia: A Systematic Review and Meta-Analysis
Prevalence of Ocular Candidiasis and <i>Candida</i> Endophthalmitis in Patients With Candidemia: A Systematic Review and Meta-Analysis Open
Background Infectious diseases and ophthalmology professional societies have disagreed regarding ocular screening in patients with candidemia. We aimed to summarize the current evidence on the prevalence of ocular candidiasis (OC) and Cand…
View article: Immunogenicity of SARS-CoV-2 vaccines in patients with multiple myeloma: a systematic review and meta-analysis
Immunogenicity of SARS-CoV-2 vaccines in patients with multiple myeloma: a systematic review and meta-analysis Open
Patients with multiple myeloma (MM) have a diminished immune response to coronavirus disease 2019 (COVID-19) vaccines. Risk factors for an impaired immune response are yet to be determined. We aimed to summarize the COVID-19 vaccine immuno…
View article: Diagnosis and Antifungal Prophylaxis for COVID-19 Associated Pulmonary Aspergillosis
Diagnosis and Antifungal Prophylaxis for COVID-19 Associated Pulmonary Aspergillosis Open
The COVID-19 pandemic has redemonstrated the importance of the fungal-after-viral phenomenon, and the question of whether prophylaxis should be used to prevent COVID-19-associated pulmonary aspergillosis (CAPA). A distinct pathophysiology …
View article: Rezafungin versus caspofungin for treatment of candidaemia and invasive candidiasis (ReSTORE): a multicentre, double-blind, double-dummy, randomised phase 3 trial
Rezafungin versus caspofungin for treatment of candidaemia and invasive candidiasis (ReSTORE): a multicentre, double-blind, double-dummy, randomised phase 3 trial Open
View article: Development of an Interferon-Gamma Release Assay (IGRA) to Aid Diagnosis of Histoplasmosis
Development of an Interferon-Gamma Release Assay (IGRA) to Aid Diagnosis of Histoplasmosis Open
Establishing diagnosis of latent and active histoplasmosis is challenging. Interferon gamma-release assays (IGRAs) may provide evidence of latent and active infection.
View article: Immunogenicity and Risk Factors Associated With Poor Humoral Immune Response of SARS-CoV-2 Vaccines in Recipients of Solid Organ Transplant
Immunogenicity and Risk Factors Associated With Poor Humoral Immune Response of SARS-CoV-2 Vaccines in Recipients of Solid Organ Transplant Open
In this systematic review and meta-analysis, the rates of positive antibody response in solid organ transplant recipients remained low despite multiple doses of mRNA vaccines. These findings suggest that more efforts are needed to modulate…
View article: Secondary Bacterial and Fungal Pneumonia Complicating SARS-CoV-2 and Influenza Infections in Lung Transplant Recipients
Secondary Bacterial and Fungal Pneumonia Complicating SARS-CoV-2 and Influenza Infections in Lung Transplant Recipients Open
View article: Respiratory Syncytial Virus, Human Metapneumovirus, and Parainfluenza Virus Infections in Lung Transplant Recipients: A Systematic Review of Outcomes and Treatment Strategies
Respiratory Syncytial Virus, Human Metapneumovirus, and Parainfluenza Virus Infections in Lung Transplant Recipients: A Systematic Review of Outcomes and Treatment Strategies Open
Background Respiratory syncytial virus (RSV), parainfluenza virus (PIV), and human metapneumovirus (hMPV) are increasingly associated with chronic lung allograft dysfunction (CLAD) in lung transplant recipients (LTR). This systematic revie…
View article: 944. CMV Peak Viral Load, Recurrence, Duration, and Outcomes in Kidney Transplant Recipients
944. CMV Peak Viral Load, Recurrence, Duration, and Outcomes in Kidney Transplant Recipients Open
Background Cytomegalovirus (CMV) infection continues to cause morbidity in kidney transplant recipients, despite prophylaxis and pre-emptive therapy. Predictors of poor outcomes remain incompletely characterized. We questioned whether mark…
View article: Tenosynovitis in a renal transplant recipient: Making the diagnosis firsthand
Tenosynovitis in a renal transplant recipient: Making the diagnosis firsthand Open
A 63-year-old man presented with 2 months of right upper extremity (RUE) redness and swelling 17 months after deceased donor renal transplant. He underwent hemodialysis for hypertension-induced renal failure for 3 years pretransplant via a…
View article: <i>Aspergillus lentulus:</i> An Under-recognized Cause of Antifungal Drug-Resistant Aspergillosis
<i>Aspergillus lentulus:</i> An Under-recognized Cause of Antifungal Drug-Resistant Aspergillosis Open
Aspergillus lentulus is a drug-resistant species that is phenotypically similar to A. fumigatus. It was discovered as a cause of azole-breakthrough disease, consistent with in vitro resistance. Clinical labs can misidentify the species as …
View article: Donor derived cell free DNA% is elevated with pathogens that are risk factors for acute and chronic lung allograft injury
Donor derived cell free DNA% is elevated with pathogens that are risk factors for acute and chronic lung allograft injury Open
View article: Does Post-Transplant Cytomegalovirus Increase the Risk of Invasive Aspergillosis in Solid Organ Transplant Recipients? A Systematic Review and Meta-Analysis
Does Post-Transplant Cytomegalovirus Increase the Risk of Invasive Aspergillosis in Solid Organ Transplant Recipients? A Systematic Review and Meta-Analysis Open
Background: Cytomegalovirus (CMV) and invasive aspergillosis (IA) cause high morbidity and mortality in solid organ transplant (SOT) recipients. There are conflicting data with respect to the impact of CMV on IA development in SOT recipien…