Nittaya Khakhum
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View article: Role of the type 6 secretion system on apoptosis and macrophage polarization during Burkholderia pseudomallei infection
Role of the type 6 secretion system on apoptosis and macrophage polarization during Burkholderia pseudomallei infection Open
Burkholderia pseudomallei ( Bpm ) is the causative agent of the disease melioidosis. As a facultative intracellular pathogen, Bpm has a complex lifestyle that culminates in cell-to-cell fusion and multinucleated giant cells (MNGCs) formati…
View article: Pathogenic and Apathogenic Strains of Lymphocytic Choriomeningitis Virus Have Distinct Entry and Innate Immune Activation Pathways
Pathogenic and Apathogenic Strains of Lymphocytic Choriomeningitis Virus Have Distinct Entry and Innate Immune Activation Pathways Open
Lymphocytic choriomeningitis virus (LCMV) and Lassa virus (LASV) share many genetic and biological features including subtle differences between pathogenic and apathogenic strains. Despite remarkable genetic similarity, the viscerotropic W…
View article: Contribution of the Type 6 Secretion System to Apoptosis and Macrophage Polarization During<i>Burkholderia pseudomallei</i>Infection
Contribution of the Type 6 Secretion System to Apoptosis and Macrophage Polarization During<i>Burkholderia pseudomallei</i>Infection Open
Burkholderia pseudomallei ( Bpm ) is the causative agent of the disease melioidosis. As a facultative intracellular pathogen, Bpm has a complex lifestyle that culminates in cell-to-cell fusion and multinucleated giant cells (MNGCs) formati…
View article: Decoration of <i>Burkholderia</i> Hcp1 protein to virus-like particles as a vaccine delivery platform
Decoration of <i>Burkholderia</i> Hcp1 protein to virus-like particles as a vaccine delivery platform Open
Virus-like particles (VLPs) are protein-based nanoparticles frequently used as carriers in conjugate vaccine platforms. VLPs have been used to display foreign antigens for vaccination and to deliver immunotherapy against diseases. Hemolysi…
View article: Decoration of<i>Burkholderia</i>Hcp1 protein to virus-like particles as a vaccine delivery platform
Decoration of<i>Burkholderia</i>Hcp1 protein to virus-like particles as a vaccine delivery platform Open
Virus-like particles (VLPs) are protein-based nanoparticles frequently used as carrier in conjugate vaccine platforms. VLPs have been used to display foreign antigens for vaccination and to deliver immunotherapeutic against diseases. Hemol…
View article: <i>Burkholderia pseudomallei</i> BicA protein promotes pathogenicity in macrophages by regulating invasion, intracellular survival, and virulence
<i>Burkholderia pseudomallei</i> BicA protein promotes pathogenicity in macrophages by regulating invasion, intracellular survival, and virulence Open
Burkholderia pseudomallei ( Bpm ) is the causative agent of melioidosis disease. Bpm is a facultative intracellular pathogen with a complex life cycle inside host cells. Pathogenic success depends on a variety of virulence factors with one…
View article: <i>Burkholderia pseudomallei</i>BicA protein promotes pathogenicity in macrophages by regulating Invasion, Intracellular Survival, and Virulence
<i>Burkholderia pseudomallei</i>BicA protein promotes pathogenicity in macrophages by regulating Invasion, Intracellular Survival, and Virulence Open
Burkholderia pseudomallei (Bpm) is the causative agent of melioidosis disease. Bpm is a facultative intracellular pathogen with a complex lifecycle inside host cells. Pathogenic success depends on a variety of virulence factors with one of…
View article: P22-Based Nanovaccines against Enterohemorrhagic Escherichia coli
P22-Based Nanovaccines against Enterohemorrhagic Escherichia coli Open
This study describes the initial attempt to use P22 viral-like particles as nanocontainers expressing enterohemorrhagic Escherichia coli (EHEC) proteins that are immunogenic and could be used as effective vaccines against EHEC infections.
View article: Dual RNA-seq reveals a type 6 secretion system-dependent blockage of TNF-α signaling and BicA as a <i>Burkholderia pseudomallei</i> virulence factor important during gastrointestinal infection
Dual RNA-seq reveals a type 6 secretion system-dependent blockage of TNF-α signaling and BicA as a <i>Burkholderia pseudomallei</i> virulence factor important during gastrointestinal infection Open
Melioidosis is a disease caused by the Gram-negative bacillus Burkholderia pseudomallei (Bpm), commonly found in soil and water of endemic areas. Naturally acquired human melioidosis infections can result from either exposure…
View article: Development of Melioidosis Subunit Vaccines Using an Enzymatically Inactive Burkholderia pseudomallei AhpC
Development of Melioidosis Subunit Vaccines Using an Enzymatically Inactive Burkholderia pseudomallei AhpC Open
Burkholderia pseudomallei , the causative agent of melioidosis, is a facultative intracellular, Gram-negative pathogen that is highly infectious via the respiratory route and can cause severe, debilitating, and often fatal diseases in huma…
View article: Evaluating the Contribution of the Predicted Toxin–Antitoxin System HigBA to Persistence, Biofilm Formation, and Virulence in Burkholderia pseudomallei
Evaluating the Contribution of the Predicted Toxin–Antitoxin System HigBA to Persistence, Biofilm Formation, and Virulence in Burkholderia pseudomallei Open
Melioidosis is an underreported human disease caused by the Gram-negative intracellular pathogen Burkholderia pseudomallei ( Bpm ). Both the treatment and the clearance of the pathogen are challenging, with high relapse rates leading to la…
View article: Recent Progress in Shigella and Burkholderia pseudomallei Vaccines
Recent Progress in Shigella and Burkholderia pseudomallei Vaccines Open
Significant advancement has been made in the development of vaccines against bacterial pathogens. However, several roadblocks have been found during the evaluation of vaccines against intracellular bacterial pathogens. Therefore, new lesso…
View article: Antigen-specific antibody and polyfunctional T cells generated by respiratory immunization with protective Burkholderia ΔtonB Δhcp1 live attenuated vaccines
Antigen-specific antibody and polyfunctional T cells generated by respiratory immunization with protective Burkholderia ΔtonB Δhcp1 live attenuated vaccines Open
Melioidosis, caused by Burkholderia pseudomallei ( Bpm ), lacks a vaccine. We identify the immune correlates of protection induced by B. mallei Δ tonB Δ hcp1 (CLH001) and Bpm Δ tonB Δ hcp1 ( PBK001) vaccines against inhalational melioidosi…
View article: Combating the great mimicker: latest progress in the development of<i>Burkholderia pseudomallei</i>vaccines
Combating the great mimicker: latest progress in the development of<i>Burkholderia pseudomallei</i>vaccines Open
Introduction Burkholderia pseudomallei is an environmental intracellular Gram-negative bacterium that causes melioidosis, a severe infectious disease affecting humans and animals. An increase in melioidosis cases worldwide and the high mor…
View article: Evaluation of Burkholderia mallei ΔtonB Δhcp1 (CLH001) as a live attenuated vaccine in murine models of glanders and melioidosis
Evaluation of Burkholderia mallei ΔtonB Δhcp1 (CLH001) as a live attenuated vaccine in murine models of glanders and melioidosis Open
Our data indicate that CLH001 serves as an effective live attenuated vaccine to prevent glanders and melioidosis. The quantity and quality of antibody responses as well as improving cell-mediated immune responses following vaccination need…
View article: Burkholderia pseudomallei Δ <i>tonB</i> Δ <i>hcp1</i> Live Attenuated Vaccine Strain Elicits Full Protective Immunity against Aerosolized Melioidosis Infection
Burkholderia pseudomallei Δ <i>tonB</i> Δ <i>hcp1</i> Live Attenuated Vaccine Strain Elicits Full Protective Immunity against Aerosolized Melioidosis Infection Open
In recent years, an increasing number of melioidosis cases have been reported in several regions where melioidosis is endemic and in areas where melioidosis had not commonly been diagnosed. Currently, the estimated burden of disease is aro…
View article: A Novel Multifunctional β-N-Acetylhexosaminidase Revealed through Metagenomics of an Oil-Spilled Mangrove
A Novel Multifunctional β-N-Acetylhexosaminidase Revealed through Metagenomics of an Oil-Spilled Mangrove Open
The use of culture-independent approaches, such as metagenomics, provides complementary access to environmental microbial diversity. Mangrove environments represent a highly complex system with plenty of opportunities for finding singular …
View article: Cloning, expression, and characterization of a peptidoglycan hydrolase from the Burkholderia pseudomallei phage ST79
Cloning, expression, and characterization of a peptidoglycan hydrolase from the Burkholderia pseudomallei phage ST79 Open
The lytic phage ST79 of Burkholderia pseudomallei can lyse a broad range of its host including antibiotic resistant isolates from within using a set of proteins, holin, lysB, lysC and endolysin, a peptidoglycan (PG) hydrolase enzyme. The p…