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View article: One-pot synthesis of silver-based chitosan macromolecular hydrogels and its antimicrobial activity
One-pot synthesis of silver-based chitosan macromolecular hydrogels and its antimicrobial activity Open
This study focused on the description of a new methodology for preparing AgNP-loaded chitosan-based hydrogels via a one-pot procedure through the thermal decomposition of urea. This new methodology enhanced the controlled production of AgN…
View article: Evaluation of the adsorption capacity of crude diatomite in the removal of Losartan from synthetic aqueous solutions
Evaluation of the adsorption capacity of crude diatomite in the removal of Losartan from synthetic aqueous solutions Open
The presence of emerging contaminants, such as pharmaceuticals, in different water sources has been increasingly studied in recent years due to their long-term negative effects on the environment and human health. Considering that conventi…
View article: Silver nanoparticles incorporated with enzymatically derived chitooligosaccharides: preparation, characterization, and biological potential evaluation
Silver nanoparticles incorporated with enzymatically derived chitooligosaccharides: preparation, characterization, and biological potential evaluation Open
In this work, silver nanoparticles (AgNPs) were elaborated using a simple, low-cost, and reproducible method by thermal treatment at 90°C of chitooligosaccharides (COSs), produced by chitosan depolymerization using the digestives chitosana…
View article: Chitosan-Coated Liposome Formulations for Encapsulation of Ciprofloxacin and Etoposide
Chitosan-Coated Liposome Formulations for Encapsulation of Ciprofloxacin and Etoposide Open
Cancer and bacterial infections rank among the most significant global health threats. accounting for roughly 25 million fatalities each year. This statistic underscores the urgent necessity for developing novel drugs, enhancing current tr…
View article: Strategies to Prepare Chitin and Chitosan-Based Bioactive Structures Aided by Deep Eutectic Solvents: A Review
Strategies to Prepare Chitin and Chitosan-Based Bioactive Structures Aided by Deep Eutectic Solvents: A Review Open
Chitin and chitosan, abundant biopolymers derived from the shells of crustaceans and the cell walls of fungi, have garnered considerable attention in pharmaceutical circles due to their biocompatibility, biodegradability, and versatile pro…
View article: Evaluation of chitosan salt properties in the production of AgNPs materials with antibacterial activity
Evaluation of chitosan salt properties in the production of AgNPs materials with antibacterial activity Open
In this study, water-soluble chitosan salts (chitosan amine sulfopropyl salts) were prepared from chitosan samples with different molecular weights and deacetylation degrees. These soluble-in-water polymer salts allowed us to produce, in a…
View article: Fast and Sustained Axonal Growth by BDNF Released from Chitosan Microspheres
Fast and Sustained Axonal Growth by BDNF Released from Chitosan Microspheres Open
Brain-derived neurotrophic factor (BDNF) regulates dendritic branching and dendritic spine morphology, as well as synaptic plasticity and long-term potentiation. Consequently, BDNF deficiency has been associated with some neurological diso…
View article: Exploring Saduria entomon (Crustacea Isopoda) as a New Source for Chitin and Chitosan Isolation
Exploring Saduria entomon (Crustacea Isopoda) as a New Source for Chitin and Chitosan Isolation Open
Chitin and chitosan demand is growing very fast due to interest from industries such as pharmaceutical, cosmetic, agricultural and others. New sources for chitin and chitosan isolation are being extensively searched to fulfil this demand. …
View article: Development of Methotrexate Complexes Endowed with New Biological Properties Envisioned for Musculoskeletal Regeneration in Rheumatoid Arthritis Environments
Development of Methotrexate Complexes Endowed with New Biological Properties Envisioned for Musculoskeletal Regeneration in Rheumatoid Arthritis Environments Open
Methotrexate (MTX) administration is the gold standard treatment for rheumatoid arthritis (RA), but its effects are limited to preventing the progression of the disease. Therefore, effective regenerative therapies for damaged tissues are s…
View article: Evaluating Non-Conventional Chitosan Sources for Controlled Release of Risperidone
Evaluating Non-Conventional Chitosan Sources for Controlled Release of Risperidone Open
In this work, two chitosan samples from cuttlebone and squid pen are produced and characterized. We studied the formation of thermoresponsive hydrogels with β-glycerol phosphate and found proper formulations that form the hydrogels at 37 °…
View article: Chitin- and Chitosan-Based Composite Materials
Chitin- and Chitosan-Based Composite Materials Open
Chitin and its deacetylated derivative chitosan are amino polysaccharides of great interest due to their biological and technological properties [...]
View article: Chitosan: An Overview of Its Properties and Applications
Chitosan: An Overview of Its Properties and Applications Open
Chitosan has garnered much interest due to its properties and possible applications. Every year the number of publications and patents based on this polymer increase. Chitosan exhibits poor solubility in neutral and basic media, limiting i…
View article: Chitosan: A Versatile Polymer for 21st Century
Chitosan: A Versatile Polymer for 21st Century Open
Chitosan arouses large interest due to its properties and possible applications. Every year the number of publications and patents based on this polymer increases. Chitosan exhibits poor solubility in neutral and basic media limiting its u…
View article: Chitosan Depolymerization: A Simple and Promising Chemical Process for the Preparation of Bioactive Varying Molecular Weight Derivatives
Chitosan Depolymerization: A Simple and Promising Chemical Process for the Preparation of Bioactive Varying Molecular Weight Derivatives Open
In order to improve functional and biological properties of shrimp chitosan and to facilitate its utilization, chitosan derivatives were prepared by chemical depolymerization using hydrochloric acid (6 M) during 2 h. The obtained chitosan …
View article: Dextran Aldehyde in Biocatalysis: More Than a Mere Immobilization System
Dextran Aldehyde in Biocatalysis: More Than a Mere Immobilization System Open
Dextran aldehyde (dexOx), resulting from the periodate oxidative cleavage of 1,2-diol moiety inside dextran, is a polymer that is very useful in many areas, including as a macromolecular carrier for drug delivery and other biomedical appli…
View article: Diseño de una formulación parenteral para la liberación prolongada de risperidona basada en un sistema de gelificación in situ
Diseño de una formulación parenteral para la liberación prolongada de risperidona basada en un sistema de gelificación in situ Open
Introducción: los sistemas de administración parenteral a base de formulaciones líquidas que gelifican in situ que forman implantes semisólidos de libración sostenida de fármacos después de la inyección, son muy atractivos por varias razon…
View article: Influence of Preparation Methods of Chitooligosaccharides on Their Physicochemical Properties and Their Anti-Inflammatory Effects in Mice and in RAW264.7 Macrophages
Influence of Preparation Methods of Chitooligosaccharides on Their Physicochemical Properties and Their Anti-Inflammatory Effects in Mice and in RAW264.7 Macrophages Open
The methods to obtain chitooligosaccharides are tightly related to the physicochemical properties of the end products. Knowledge of these physicochemical characteristics is crucial to describing the biological functions of chitooligosaccha…
View article: On the Ability of Low Molecular Weight Chitosan Enzymatically Depolymerized to Produce and Stabilize Silver Nanoparticles
On the Ability of Low Molecular Weight Chitosan Enzymatically Depolymerized to Produce and Stabilize Silver Nanoparticles Open
Silver nanoparticles (AgNPs) are of great interest due to their antimicrobial, optical and catalytical properties. Green synthesis of AgNPs is fundamental for some applications such as biomedicine and catalysis. Natural polymers, such as c…
View article: Synthesis, physicochemical characterization and biological evaluation of chitosan sulfate as heparan sulfate mimics
Synthesis, physicochemical characterization and biological evaluation of chitosan sulfate as heparan sulfate mimics Open
View article: Cosmetics and Cosmeceutical Applications of Chitin, Chitosan and Their Derivatives
Cosmetics and Cosmeceutical Applications of Chitin, Chitosan and Their Derivatives Open
Marine resources are well recognized for their biologically active substances with great potential applications in the cosmeceutical industry. Among the different compounds with a marine origin, chitin and its deacetylated derivative—chito…
View article: Chitosan Spray-Dried Microparticles for Controlled Delivery of Venlafaxine Hydrochloride
Chitosan Spray-Dried Microparticles for Controlled Delivery of Venlafaxine Hydrochloride Open
Venlafaxine controlled drug delivery systems using different matrixes have been tested to reduce undesirable side effects in the treatment of depression. The legal status of chitosan (Cs) in Pharmacy has dramatically improved after its acc…
View article: Physical Stability Studies of Semi-Solid Formulations from Natural Compounds Loaded with Chitosan Microspheres
Physical Stability Studies of Semi-Solid Formulations from Natural Compounds Loaded with Chitosan Microspheres Open
A chitosan-based hydrophilic system containing an olive leaf extract was designed and its antioxidant capacity was evaluated. Encapsulation of olive leaf extract in chitosan microspheres was carried out by a spray-drying process. The parti…