Niusha Nikravesh
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View article: Go with the flow: An in vitro model of a mature endothelium for the study of the bioresponse of IV injectable nanomedicines
Go with the flow: An in vitro model of a mature endothelium for the study of the bioresponse of IV injectable nanomedicines Open
The first exposure of intravenously (IV) administered nanomedicines in vivo is to endothelial cells (ECs) lining blood vessels. While it is known that in vitro endothelium models to assess responses to circulating nanoparticles require she…
View article: Endothelium Response to Iron Sucrose Nanoparticles in Static Versus Dynamic Culture Model
Endothelium Response to Iron Sucrose Nanoparticles in Static Versus Dynamic Culture Model Open
Nanomedicines are promising therapeutic compounds allowing the development of new treatment approaches. However, important factors affecting the behavior of nanoparticles in vivo cannot be simulated in conventional static models. Dynamic c…
View article: Factors influencing safety and efficacy of intravenous iron-carbohydrate nanomedicines: From production to clinical practice
Factors influencing safety and efficacy of intravenous iron-carbohydrate nanomedicines: From production to clinical practice Open
Iron deficiency is an important subclinical disease affecting over one billion people worldwide. A growing body of clinical records supports the use of intravenous iron-carbohydrate complexes for patients where iron replenishment is necess…
View article: Physical Structuring of Injectable Polymeric Systems to Controllably Deliver Nanosized Extracellular Vesicles
Physical Structuring of Injectable Polymeric Systems to Controllably Deliver Nanosized Extracellular Vesicles Open
Extracellular vesicles (EVs) are emerging as a promising alternative approach to cell‐therapies. However, to realize the potential of these nanoparticles as new regenerative tools, healthcare materials that address the current limitations …
View article: Encapsulation of pancreatic beta cells
Encapsulation of pancreatic beta cells Open
Immunoisolation of pancreatic beta cells is a promising approach for the treatment of type I diabetes. In this thesis, a vibrating nozzle technology was utilised to reproducibly generate 1% alginate microparticles with an average diameter …