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View article: Metabolism-based scoring of cutaneous squamous cell carcinoma to predict tumour features and responses to treatment with dihydroorotate dehydrogenase inhibitors
Metabolism-based scoring of cutaneous squamous cell carcinoma to predict tumour features and responses to treatment with dihydroorotate dehydrogenase inhibitors Open
Background Alteration in metabolic activities is a critical step in cancer progression. Myriad metabolic-based therapy options are increasingly being proposed for human tumours. However, emerging evidence highlights interpatient metabolic …
View article: Repression of oxidative phosphorylation by NR2F2, MTERF3 and GDF15 in human skin under high-glucose stress
Repression of oxidative phosphorylation by NR2F2, MTERF3 and GDF15 in human skin under high-glucose stress Open
View article: Rewiring Lipid Metabolism by Targeting PCSK9 and HMGCR to Treat Liver Cancer
Rewiring Lipid Metabolism by Targeting PCSK9 and HMGCR to Treat Liver Cancer Open
Alterations in lipid handling are an important hallmark in cancer. Our aim here is to target key metabolic enzymes to reshape the oncogenic lipid metabolism triggering irreversible cell breakdown. We targeted the key metabolic player propr…
View article: HRAS germline mutations impair LKB1/AMPK signaling and mitochondrial homeostasis in Costello syndrome models
HRAS germline mutations impair LKB1/AMPK signaling and mitochondrial homeostasis in Costello syndrome models Open
Germline mutations that activate genes in the canonical RAS/MAPK signaling pathway are responsible for rare human developmental disorders known as RASopathies. Here, we analyzed the molecular determinants of Costello syndrome (CS) using a …
View article: Proteomic Study of Low-Birth-Weight Nephropathy in Rats
Proteomic Study of Low-Birth-Weight Nephropathy in Rats Open
The hyperfiltration theory has been used to explain the mechanism of low birth weight (LBW)-related nephropathy. However, the molecular changes in the kidney proteome have not been defined in this disease, and early biomarkers are lacking.…
View article: Crucial role of fatty acid oxidation in asthmatic bronchial smooth muscle remodelling
Crucial role of fatty acid oxidation in asthmatic bronchial smooth muscle remodelling Open
Background Bronchial smooth muscle (BSM) remodelling in asthma is related to an increased mitochondrial biogenesis and enhanced BSM cell proliferation in asthma. Since mitochondria produce the highest levels of cellular energy and fatty ac…
View article: A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity
A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity Open
During the cancerous transformation of normal hepatocytes into hepatocellular carcinoma (HCC), the enzyme catalyzing the first rate-limiting step of glycolysis, namely the glucokinase (GCK), is replaced by the higher affinity isoenzyme, he…
View article: A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity
A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity Open
View article: Targeting the mitochondrial trifunctional protein restrains tumor growth in oxidative lung carcinomas
Targeting the mitochondrial trifunctional protein restrains tumor growth in oxidative lung carcinomas Open
Metabolic reprogramming is a common hallmark of cancer, but a large variability in tumor bioenergetics exists between patients. Using high-resolution respirometry on fresh biopsies of human lung adenocarcinoma, we identified 2 subgroups re…
View article: Chemical targeting of NEET proteins reveals their function in mitochondrial morphodynamics
Chemical targeting of NEET proteins reveals their function in mitochondrial morphodynamics Open
View article: Lipogenesis and innate immunity in hepatocellular carcinoma cells reprogrammed by an isoenzyme switch of hexokinases
Lipogenesis and innate immunity in hepatocellular carcinoma cells reprogrammed by an isoenzyme switch of hexokinases Open
During the cancerous transformation of normal hepatocytes into hepatocellular carcinoma (HCC), the enzyme catalyzing the first rate-limiting step of glycolysis, namely the glucokinase (GCK), is replaced by the higher affinity isoenzyme, he…
View article: Mitochondrial Physiology
Mitochondrial Physiology Open
As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent…
View article: Metabolic reprogramming by tobacco-specific nitrosamines (TSNAs) in cancer
Metabolic reprogramming by tobacco-specific nitrosamines (TSNAs) in cancer Open
Metabolic reprogramming is a hallmark of cancer and the link between oncogenes activation, tumor supressors inactivation and bioenergetics modulation is well established. However, numerous carcinogenic environmental factors are responsible…
View article: Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F
Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F Open
View article: Mitochondrial respiratory states and rates
Mitochondrial respiratory states and rates Open
As the knowledge base and importance of mitochondrial physiology to human health expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmoti…
View article: Redox mechanism of levobupivacaine cytostatic effect on human prostate cancer cells
Redox mechanism of levobupivacaine cytostatic effect on human prostate cancer cells Open
View article: Metabolic Reprogramming in Amyotrophic Lateral Sclerosis
Metabolic Reprogramming in Amyotrophic Lateral Sclerosis Open
Mitochondrial dysfunction in the spinal cord is a hallmark of amyotrophic lateral sclerosis (ALS), but the neurometabolic alterations during early stages of the disease remain unknown. Here, we investigated the bioenergetic and proteomic c…