Niya Wang
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View article: Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages
Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages Open
Significant efforts have harvested a sophisticated understanding of Alzheimer's disease (AD) including amyloid beta (Aβ) cascade mechanisms, although effective treatment for reversing or stopping AD progression is not available. This study…
Differences in climate change impacts on reptile embryos and adults Open
Species experience climate change impacts throughout their life cycle; yet, embryos are rarely considered in vulnerability assessments and conservation planning. We conducted a global‐scale analysis of developmental traits and climate chan…
Mechanistic Role of Astrocytic Rac1 Protein in Alzheimer's Disease Open
The prevalence of Alzheimer's disease (AD) has been increasing worldwide due to the aging population, placing a substantial burden on both society and families. To date, the underlying pathogenesis of AD has not been comprehensively elucid…
Multi-Agent Collaborative Path Planning Algorithm with Multiple Meeting Points Open
Traditional multi-agent path planning algorithms often lead to path overlap and excessive energy consumption when dealing with cooperative tasks due to the single-agent-single-task configuration. For this reason, the “many-to-one” cooperat…
A coordinated scheduling approach for task assignment and multi-agent path planning Open
Path finding is an essential problem in multi-agent systems, widely employed in warehousing and logistics. However, most of the current studies focus on the problem of assigning one agent with one task in a period, which may hinder the eff…
Anti-NMDAR antibodies, the blood–brain barrier, and anti-NMDAR encephalitis Open
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is an antibody-related autoimmune encephalitis. It is characterized by the existence of antibodies against NMDAR, mainly against the GluN1 subunit, in cerebrospinal fluid (CSF). …
Autonomous localized path planning algorithm for UAVs based on TD3 strategy Open
Aiming at the current local path planning methods for UAVs, the problem of weak portability due to the large influence of different controllers on its planning effect and the weak autonomous decision-making ability of UAV path planning, an…
Cooperation between neurovascular dysfunction and Aβ in Alzheimer’s disease Open
The amyloid-β (Aβ) hypothesis was once believed to represent the pathogenic process of Alzheimer’s disease (AD). However, with the failure of clinical drug development and the increasing understanding of the disease, the Aβ hypothesis has …
Retracted: A new aquatic beetle (Adephaga: Coptoclavidae) from the Middle Jurassic Daohugou Biota Open
Tigrivia baii gen. et sp. nov. (Coleoptera: Adephaga: Coptoclavidae) is described and named based on a fossil specimen from the Middle Jurassic Daohugou Biota, Nincheng County, Inner Mongolia of China. The fossil is very similar in morphol…
A Clustering-Enhanced Memetic Algorithm for the Quadratic Minimum Spanning Tree Problem Open
The quadratic minimum spanning tree problem (QMSTP) is a spanning tree optimization problem that considers the interaction cost between pairs of edges arising from a number of practical scenarios. This problem is NP-hard, and therefore the…
View article: Growth Indicators of Main Species Predict Aboveground Biomass of Population and Community on a Typical Steppe
Growth Indicators of Main Species Predict Aboveground Biomass of Population and Community on a Typical Steppe Open
The objective was to explore a fast, accurate, non-destructive, and less disturbance method for predicting the aboveground biomass (AGB) of the typical steppe, by using plant height and canopy diameter of the dominant species, Stipa bungea…
CDK4/6 regulate lysosome biogenesis through TFEB/TFE3 Open
Lysosomes are degradation and signaling organelles that adapt their biogenesis to meet many different cellular demands; however, it is unknown how lysosomes change their numbers for cell division. Here, we report that the cyclin-dependent …
debCAM: a bioconductor R package for fully unsupervised deconvolution of complex tissues Open
Summary We develop a fully unsupervised deconvolution method to dissect complex tissues into molecularly distinctive tissue or cell subtypes based on bulk expression profiles. We implement an R package, deconvolution by Convex Analysis of …
Unsupervised deconvolution of molecular heterogeneity uncovers novel signatures and glia-neuron ratio Open
While the two major types of cells in the brain are known to be glia and neuron, the true ratio of glia to neurons in the brain remains a mystery. One of recent studies reveals that the ratio of glia to neurons in the brain varies from one…