Noor Shafina Mohd Nor
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PITUITARY HYPERPLASIA SECONDARY TO PRIMARY HYPOTHYROIDISM – A CASE REPORT Open
INTRODUCTIONPrimary hypothyroidism in children can present insidiously and mimic other systemic conditions, including neurological symptoms. In rare cases, it may lead to pituitary hyperplasia due to lack of negative feedback on thyrotroph…
ATYPICAL GENITALIA IN SILVER-RUSSELL SYNDROME Open
INTRODUCTIONSilver-Russell Syndrome (SRS) is a clinically heterogeneous disorder which is often associated with growth restriction. Genital abnormalities can be present but are not part of the diagnostic criteria. We describe one case of S…
A review of vitamin D deficiency and vitamin D receptor polymorphisms in endocrine-related disorders Open
The endocrine system is a complex network of glands that produce and release hormones that regulate various physiological processes. In the past few decades, the human skin has been identified as an important peripheral endocrine organ tha…
In-Silico Works Using an Improved Hovorka Equations Model and Clinical Works on the Control of Blood Glucose Levels in People With Type 1 Diabetes: Comparison Study Open
Background People with type 1 diabetes (T1D) depend on external insulin to regulate their blood glucose level (BGL) within the normoglycemic range between 4.0 to 7.0 mmol/L. Patients with T1D routinely conduct self-monitoring of blood gluc…
CONGENITAL HYPERINSULINISM SECONDARY TO ABCC8 MUTATION Open
INTRODUCTIONCongenital hyperinsulinism (CHI) results in persistent hypoglycaemia beyond infancy. Mutations in the ABCC8 and KCNJ11 genes are the most common aetiologies of congenital hyperinsulinism that leads to inappropriate insulin secr…
VITAMIN D DEFICIENCIES Open
INTRODUCTIONIn the post COVID era, the prevalence of overweight and obesity in children and adolescents is increasing, leading to multiple obesity-related comorbidities. Despite Malaysia being a tropical country, the occurrence of vitamin …
Authors’ Response to Peer Reviews of “In-Silico Works Using an Improved Hovorka Equations Model and Clinical Works on the Control of Blood Glucose Levels in People With Type 1 Diabetes: Comparison Study” (Preprint) Open
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Distinct gut flora profile induced by postnatal trans-fat diet in gestationally bisphenol A-exposed rats Open
There has been much evidence showing the repercussions of prenatal bisphenol A (BPA) exposure with a postnatal high fat-diet (HFD) on offspring’s health. However, the information on how the interaction between these two variables affects t…
Atypical Congenital Adrenal Hyperplasia (CAH) Presentation of A Patient, Resulting in A Similar Diagnosis for His Sibling Open
Introduction: Congenital adrenal hyperplasia (CAH) is the commonest cause of primary adrenal insufficiency and is known to be transmitted in an autosomal recessive manner. We report two cases of male siblings with CAH. Cases: The elder sib…
Establishment of Reference Intervals of Blood Parameters Among the Healthy Afghan Population Open
Therefore, we conclude that the commonly used reference intervals should be revised for the Afghan population, as our findings indicated higher reference values for the hemoglobin and hematocrit indices.
Type 1 Diabetes Mellitus Patients' Self-perception of Periodontal Diseases Open
Objectives The study aimed to evaluate type 1 diabetes mellitus (T1DM) patients' self-perceived periodontal health status and to identify the association between periodontal disease (PD) and DM. Materials and Methods This cross-sectional s…
Knowledge and perception of bidirectional relationship between periodontal disease and type 1 diabetes mellitus: A questionnaire study Open
A bstract Aim: The bidirectional relationship between type 1 diabetes mellitus (T1DM) and inflammatory periodontal disease (PD) is globally recognized. However, oral health components are often given lower priority, and studies related to …
A CASE OF AUTOSOMAL DOMINANT OSTEOPETROSIS TYPE 2 WITH A CLCN7 GENE MUTATION Open
INTRODUCTION/BACKGROUNDNon-classical congenital adrenal hyperplasia (NCCAH) usually has a late presentation as compared to classical CAH as the presentation is often atypical. Presentation in boys can be asymptomatic through family screeni…
The effects of trans fat diet intake on metabolic parameters and pancreatic tissue in offspring of prenatal bisphenol A exposed rats Open
Bisphenol A (BPA) is a plasticiser used in the manufacturing of many products and its effects on human health remain controversial. Up till now, BPA involvement in metabolic syndrome risk and development is still not fully understood. In t…
Type 1 Diabetes Mellitus (T1DM) patients' self-perception of periodontal diseases Open
Objective : The study aimed to evaluate type 1 DM (T1DM) patients’ self-perceived periodontal health status and to identify the association between PD and DM. Methods : This cross-sectional study included 113 T1DM children between 3 and 18…
In-Silico Works Using an Improved Hovorka Equations Model and Clinical Works on the Control of Blood Glucose Levels in People With Type 1 Diabetes: Comparison Study (Preprint) Open
BACKGROUND People with type 1 diabetes (T1D) depend on external insulin to regulate their blood glucose level (BGL) within the normoglycemic range between 4.0 to 7.0 mmol/L. Patients with T1D routinely conduct self-monitoring of blood gluc…
Comparative Study between In-silico and Clinical Works on the Control of Blood Glucose Level in People with Type 1 Diabetes using Improved Hovorka Equations Open
Background Hovorka model is one of the diabetic models which is widely used in the artificial pancreas device (APD) also known as closed loop system, meant for people with type 1 diabetes (T1D). Previous workers had modified some equations…
A FAMILY WITH HYPOGONADOTROPIC HYPOGONADISM AND A NOVEL VARIANT OF FGFR1 GENE MUTATION Open
INTRODUCTION FGFR1 gene mutation is a known cause of gonadotropin deficiency such as Kallmann syndrome. We described two related young under-virilized males with a variant of FGFR1 gene mutation. Both were born in a non-consanguineous fami…
The Current Findings on the Impact of Prenatal BPA Exposure on Metabolic Parameters: In Vivo and Epidemiological Evidence Open
Metabolic syndrome (MS) is a multifactorial disease entity and is not fully understood. Growing evidence suggests that early exposure to bisphenol A (BPA) is a significant risk factor for the development of metabolic diseases. BPA is a mon…
Prenatal Bisphenol a Exposure and Postnatal Trans Fat Diet Alter Small Intestinal Morphology and Its Global DNA Methylation in Male Sprague-Dawley Rats, Leading to Obesity Development Open
In this study, we aimed to determine whether a postnatal trans fat diet (TFD) could aggravate prenatal bisphenol A (BPA) exposure effects on offspring’s small intestine and adulthood obesity, due to the relatively sparse findings on how th…
General Health of Pregnant Sprague-Dawley Rats and Neonates’ Small Intestine Morphology Upon Maternal Bisphenol A Exposure: A Preliminary Study Open
Associations between xenoestrogen bisphenol A (BPA) and multiple types of diseases, including metabolic syndrome, have been recorded in various studies. However, certain subsets of the human population are particularly more vulnerable to B…
Identification of cardiovascular risk factors among urban and rural Malaysian youths Open
Background Coronary artery disease (CAD) is one of the major causes of morbidity and mortality worldwide. Early identification of the cardiovascular risk factors (CRF) among youths assists in determining the high-risk group to develop CAD …
Congenital Adrenal Hyperplasia: Diagnostic Pitfalls in Prolonged Neonatal Jaundice Open
Congenital Adrenal Hyperplasia (CAH) is a genetic disorder that leads to cortisol deficiency. However, prolonged neonatal jaundice is a rare presentation of CAH. The pathophysiology of hyperbilirubinemia in CAH is still ill-defined. Plausi…
Rickets Due to Severe Vitamin D and Calcium Deficiency During the COVID-19 Pandemic in Malaysia Open
BACKGROUND Rickets is the deficiency in mineralization of the bone associated with lack of sunlight exposure and inadequate dietary calcium and/or vitamin D in children. Important efforts to eradicate rickets include appropriate sunlight e…
Identification of Coronary Risk Factors Among Urban and Rural Malaysian Youths and Their Possible Underlying Causes Open
Background : Coronary artery disease (CAD) is one of the major causes of morbidity and mortality worldwide. Early identification of the coronary risk factors (CRF) among youths assists in determining the high-risk group to develop CAD in l…
Glycogenic hepatopathy in children with poorly controlled type 1 diabetes mellitus Open
Mauriac syndrome is a rare and underdiagnosed complication of type 1 diabetes mellitus (T1DM). It is characterized by growth retardation, delayed puberty, Cushingoid features, hepatomegaly, and increased transaminase levels. The term glyco…
Control of Blood Glucose Level for Type 1 Diabetes Mellitus using Improved Hovorka Equations: Comparison between Clinical and In-Silico Works Open
Background Type 1 diabetes mellitus (T1DM) occurs due to inability of the body to produce sufficient amount of insulin to regulate blood glucose level (BGL) at normoglycemic range between 4.0 to 7.0 mmol/L. Thus, T1DM patients require to d…
Visible-Light Active Photocatalytic Dual Layer Hollow Fiber (DLHF) Membrane and Its Potential in Mitigating the Detrimental Effects of Bisphenol A in Water Open
The presence of bisphenol A (BPA) in various water sources has potentially led to numerous adverse effects in human such as increased in blood pressure and derangement in liver function. Thus, a reliable treatment for the removing BPA is h…