Nneka N. Ufere
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View article: Longitudinal Associations of Chemotherapy-Induced Symptom Clusters with Healthcare Utilization and Mortality among Patients with Gastrointestinal Cancers
Longitudinal Associations of Chemotherapy-Induced Symptom Clusters with Healthcare Utilization and Mortality among Patients with Gastrointestinal Cancers Open
Background Chemotherapy (ChT) induced neurological and gastrointestinal (GI) symptom clusters are common, but their longitudinal associations with healthcare utilization and mortality remain unclear. Methods We conducted a retrospective st…
View article: Patient-Reported Symptom Assessments and Early Chemotherapy Discontinuation in Routine Gastrointestinal Cancer Care
Patient-Reported Symptom Assessments and Early Chemotherapy Discontinuation in Routine Gastrointestinal Cancer Care Open
Background Early chemotherapy (CTh) discontinuation in gastrointestinal (GI) cancer patients can compromise treatment effectiveness and worsen outcomes. Clinical trials show that monitoring and addressing patient-reported symptoms may redu…
View article: Domains of prognostic awareness, quality of life, and psychological distress in patients with advanced cancer
Domains of prognostic awareness, quality of life, and psychological distress in patients with advanced cancer Open
Introduction Prior studies have shown mixed findings regarding the relationship between prognostic awareness with quality of life (QOL) and psychological distress in patients with advanced cancer. Prognostic awareness is a multidimensional…
View article: Differential Item Functioning of the Patient Health Questionnaire-9 in Decompensated Cirrhosis
Differential Item Functioning of the Patient Health Questionnaire-9 in Decompensated Cirrhosis Open
INTRODUCTION: We examined whether the symptom expression of depression as assessed using the Patient Health Questionnaire-9 (PHQ-9) depression screening tool differs between patients with decompensated cirrhosis (DC) compared with primary …
View article: Accuracy of the “Surprise Question” in predicting 90-day mortality among hospitalized patients with decompensated cirrhosis
Accuracy of the “Surprise Question” in predicting 90-day mortality among hospitalized patients with decompensated cirrhosis Open
View article: Levels of Evidence Supporting Recommendations in Gastroenterology
Levels of Evidence Supporting Recommendations in Gastroenterology Open
INTRODUCTION: We aimed to analyze gastrointestinal guidelines to assess the quality of evidence and strength of recommendation. METHODS: We abstracted clinical practice guidelines and guidance statements from 4 American gastroenterology so…
View article: Validation of the Hospital Anxiety and Depression Scale in patients with decompensated cirrhosis
Validation of the Hospital Anxiety and Depression Scale in patients with decompensated cirrhosis Open
View article: Association of Hepatorenal Syndrome-Acute Kidney Injury with Mortality in Patients with Cirrhosis Requiring Renal Replacement Therapy
Association of Hepatorenal Syndrome-Acute Kidney Injury with Mortality in Patients with Cirrhosis Requiring Renal Replacement Therapy Open
Key Points In patients with cirrhosis and AKI requiring renal replacement therapy (RRT), hepatorenal syndrome-AKI was not associated with an increased 90-day mortality when compared with other AKI etiologies. Etiology of AKI may not be a c…
View article: Validation of the Hospital Anxiety and Depression Scale in Patients with Decompensated Cirrhosis
Validation of the Hospital Anxiety and Depression Scale in Patients with Decompensated Cirrhosis Open
Background The Hospital Anxiety and Depression Scale (HADS) demonstrates strong psychometric properties in many populations of patients with serious illness. However, its psychometric performance among patients with decompensated cirrhosis…
View article: Increasing Healthcare System Empathy for Patients with Advanced Liver Disease: My Top 10 Lessons in Palliative Hepatology
Increasing Healthcare System Empathy for Patients with Advanced Liver Disease: My Top 10 Lessons in Palliative Hepatology Open
View article: DDS Profile: Nneka N. Ufere, MD, MSCE
DDS Profile: Nneka N. Ufere, MD, MSCE Open
View article: Pragmatic strategies to address health disparities along the continuum of care in chronic liver disease
Pragmatic strategies to address health disparities along the continuum of care in chronic liver disease Open
Racial, ethnic, and socioeconomic disparities exist in the prevalence and natural history of chronic liver disease, access to care, and clinical outcomes. Solutions to improve health equity range widely, from digital health tools to policy…
View article: Quality of Life, Symptom Burden, and Prognostic Perceptions Among Patients with Decompensated Cirrhosis
Quality of Life, Symptom Burden, and Prognostic Perceptions Among Patients with Decompensated Cirrhosis Open
View article: Edmonton Symptom Assessment System is a Valid Tool to Measure Symptom Burden Among Decompensated Cirrhosis Patients (GP119)
Edmonton Symptom Assessment System is a Valid Tool to Measure Symptom Burden Among Decompensated Cirrhosis Patients (GP119) Open
View article: Qualitative Study of Longitudinal Specialty-Aligned Palliative Care for Inpatients with Advanced Liver Disease
Qualitative Study of Longitudinal Specialty-Aligned Palliative Care for Inpatients with Advanced Liver Disease Open
View article: SILK Collaborative: A Multidisciplinary Approach to Serious Illness Conversations for Patients with Liver Failure
SILK Collaborative: A Multidisciplinary Approach to Serious Illness Conversations for Patients with Liver Failure Open
View article: The Edmonton Symptom Assessment System is a valid, reliable, and responsive tool to assess symptom burden in decompensated cirrhosis
The Edmonton Symptom Assessment System is a valid, reliable, and responsive tool to assess symptom burden in decompensated cirrhosis Open
Background: While there is a growing need for interventions addressing symptom burden in patients with decompensated cirrhosis (DC), the lack of validated symptom assessment tools is a critical barrier. We investigated the psychometric pro…
View article: Healthcare Resource Utilization and Goals of Care Discussions in Patients with Cirrhosis and Acute Kidney Injury
Healthcare Resource Utilization and Goals of Care Discussions in Patients with Cirrhosis and Acute Kidney Injury Open
View article: Financial burden following adult liver transplantation is common and associated with adverse recipient outcomes
Financial burden following adult liver transplantation is common and associated with adverse recipient outcomes Open
The financial impact of liver transplantation has been underexplored. We aimed to identify associations between high financial burden (≥10% annual income spent on out-of-pocket medical costs) and work productivity, financial distress (copi…
View article: The SILK Collaborative: A Multidisciplinary Approach to Serious Illness Communication for Patients with Liver Failure and AKI
The SILK Collaborative: A Multidisciplinary Approach to Serious Illness Communication for Patients with Liver Failure and AKI Open
Saly, Danielle L.; Allegretti, Andrew S.; Ufere, Nneka N.; on behalf of the MGH SILK Collaborative Author Information
View article: Correction: Exploring gender and thematic differences in qualitative assessments of internal medicine resident performance
Correction: Exploring gender and thematic differences in qualitative assessments of internal medicine resident performance Open
View article: Analysis of narrative assessments of internal medicine resident performance: are there differences associated with gender or race and ethnicity?
Analysis of narrative assessments of internal medicine resident performance: are there differences associated with gender or race and ethnicity? Open
View article: Health care–related transportation insecurity is associated with adverse health outcomes among adults with chronic liver disease
Health care–related transportation insecurity is associated with adverse health outcomes among adults with chronic liver disease Open
Background: Health care–related transportation insecurity (delayed or forgone medical care due to transportation barriers) is being increasingly recognized as a social risk factor affecting health outcomes. We estimated the national burden…
View article: Serious Illness Communication in Cirrhosis Care: Tools to Improve Illness Understanding, Prognostic Understanding, and Care Planning
Serious Illness Communication in Cirrhosis Care: Tools to Improve Illness Understanding, Prognostic Understanding, and Care Planning Open
Patients with cirrhosis frequently experience an unpredictable illness trajectory, with frequent hospitalizations and complications. Along with the uncertain nature of the disease, the possibility of a lifesaving and curative transplant of…
View article: Improving palliative care access for patients with cirrhosis
Improving palliative care access for patients with cirrhosis Open
View article: Exploring gender and thematic differences in qualitative assessments of internal medicine resident performance
Exploring gender and thematic differences in qualitative assessments of internal medicine resident performance Open
Introduction Evidence suggests gender disparities in medical education assessment, including differences in ratings of competency and narrative comments provided in resident performance assessments. This study explores how gender manifests…
View article: Antibiotic prophylaxis in palliative patients with cirrhosis: Stewardship or gatekeeping?
Antibiotic prophylaxis in palliative patients with cirrhosis: Stewardship or gatekeeping? Open
To the editor: Crocombe et al's1 evidence-based review of antibiotic prophylaxis in decompensated cirrhosis is commendable given the high morbidity and mortality associated with antimicrobial resistance, and we await the results of the ASP…
View article: Incidence and outcomes of acute kidney injury including hepatorenal syndrome in hospitalized patients with cirrhosis in the US
Incidence and outcomes of acute kidney injury including hepatorenal syndrome in hospitalized patients with cirrhosis in the US Open
View article: Palliative clinical trials in advanced chronic liver disease: Challenges and opportunities
Palliative clinical trials in advanced chronic liver disease: Challenges and opportunities Open
Patients with advanced chronic liver disease have a complex symptom burden and many are not candidates for curative therapy. Despite this, provision of palliative interventions remains woefully inadequate, with an insufficient evidence bas…
View article: Targets and study design for symptom-focused trials aimed at patients with cirrhosis: An expert consensus
Targets and study design for symptom-focused trials aimed at patients with cirrhosis: An expert consensus Open
Background: Symptom-focused trials are critically needed for patients with cirrhosis. However, this work would benefit from standard processes and validated measures. Methods: A writing group was formed among hepatologists, nurses, palliat…