Noah Eckman
YOU?
Author Swipe
View article: Cross-Molecular Active Learning for the Discovery of Antimicrobial Polyacrylamides
Cross-Molecular Active Learning for the Discovery of Antimicrobial Polyacrylamides Open
Antimicrobial resistance poses an urgent and increasing threat to global health. The development of new antimicrobials is crucial. Synthetic copolymers are attractive as a potential solution, because they can be produced at scale and desig…
View article: A Transient Immunostimulatory Niche Synergizes Adoptive and Endogenous Immunity for Enhanced Tumor Control
A Transient Immunostimulatory Niche Synergizes Adoptive and Endogenous Immunity for Enhanced Tumor Control Open
Adoptive Cell Therapy (ACT) has achieved curative responses in hematological malignancies, yet its translation to solid tumors remains limited by manufacturing bottlenecks, systemic toxicities, and poor T-cell infiltration and persistence …
View article: Long-acting hydrogel-based depot formulations of tirzepatide and semaglutide for the management of type 2 diabetes and weight
Long-acting hydrogel-based depot formulations of tirzepatide and semaglutide for the management of type 2 diabetes and weight Open
Several incretin hormone therapies have been clinically approved and have revolutionized the treatment of diabetes and obesity. Promising therapeutics include semaglutide (Ozempic and Wegovy), an agonist for glucagon-like peptide-1 (GLP-1)…
View article: Engineering Sustained-Release Broadly Neutralizing Antibody Formulations
Engineering Sustained-Release Broadly Neutralizing Antibody Formulations Open
Sustained serum levels of broadly neutralizing antibodies (bnAbs) are crucial for effective passive immunization against infectious diseases as protection persists only while these bnAbs remain at adequate concentrations within the body. C…
View article: Generation of an inflammatory niche in a hydrogel depot through recruitment of key immune cells improves efficacy of mRNA vaccines
Generation of an inflammatory niche in a hydrogel depot through recruitment of key immune cells improves efficacy of mRNA vaccines Open
Messenger RNA (mRNA) delivered in lipid nanoparticles (LNPs) rose to the forefront of vaccine candidates during the COVID-19 pandemic due to scalability, adaptability, and potency. Yet, there remain critical areas for improvements of these…
View article: Crosslink Dynamics Control Injection Force and Flow Profiles of Non-Covalent Gels
Crosslink Dynamics Control Injection Force and Flow Profiles of Non-Covalent Gels Open
Dynamically crosslinked hydrogels have found remarkable utility in 3D bioprinting and injectable slow-release delivery of pharmaceutics and vaccines, applications which take advantage of their ability to flow through needles or extrusion d…
View article: Highly Extensible Physically Crosslinked Hydrogels for High‐Speed 3D Bioprinting
Highly Extensible Physically Crosslinked Hydrogels for High‐Speed 3D Bioprinting Open
Hydrogels have emerged as promising materials for bioprinting and many other biomedical applications due to their high degree of biocompatibility and ability to support and/or modulate cell viability and function. Yet, many hydrogel bioink…
View article: Clonally expanded, targetable, natural killer-like NKG7 T cells seed the aged spinal cord to disrupt myeloid-dependent wound healing
Clonally expanded, targetable, natural killer-like NKG7 T cells seed the aged spinal cord to disrupt myeloid-dependent wound healing Open
Spinal cord injury (SCI) increasingly affects aged individuals, where functional impairment and mortality are highest. However, the aging-dependent mechanisms underpinning tissue damage remain elusive. Here, we find that natural killer-lik…
View article: Defining Structure‐Function Relationships of Amphiphilic Excipients Enables Rational Design of Ultra‐Stable Biopharmaceuticals
Defining Structure‐Function Relationships of Amphiphilic Excipients Enables Rational Design of Ultra‐Stable Biopharmaceuticals Open
Biopharmaceuticals are the fastest‐growing class of drugs in the healthcare industry, but their global reach is severely limited by their propensity for rapid aggregation. Currently, surfactant excipients such as polysorbates and poloxamer…
View article: Crosslink strength governs yielding behavior in dynamically crosslinked hydrogels
Crosslink strength governs yielding behavior in dynamically crosslinked hydrogels Open
Injectable hydrogels have spawned great interest as vehicles for cell therapy. We find that crosslink strength controls the solid-to-liquid yielding transition; further, stronger crosslinks lead to brittle yielding, reducing injected cell …
View article: A thiol–ene click-based strategy to customize injectable polymer–nanoparticle hydrogel properties for therapeutic delivery
A thiol–ene click-based strategy to customize injectable polymer–nanoparticle hydrogel properties for therapeutic delivery Open
We have developed a straightforward strategy to tune the interaction strength of supramolecular polymer–nanoparticle hydrogels that provides customized properties for a variety of biomedical applications.
View article: Crosslink Strength Governs Yielding Behavior in Dynamically Crosslinked Hydrogels
Crosslink Strength Governs Yielding Behavior in Dynamically Crosslinked Hydrogels Open
Summary Yielding of dynamically crosslinked hydrogels, or transition between a solid-like and liquid-like state, allows facile injection and utility in translational biomedical applications including delivery of therapeutic cells. Unfortun…
View article: Highly Extensible Physically Crosslinked Hydrogels for High-Speed 3D Bioprinting
Highly Extensible Physically Crosslinked Hydrogels for High-Speed 3D Bioprinting Open
Hydrogels have emerged as promising materials for bioprinting and many other biomedical applications due to their high degree of biocompatibility and ability to support and/or modulate cell viability and function. Yet, many hydrogel bioink…
View article: Generation of an inflammatory niche in an injectable hydrogel depot through recruitment of key immune cells improves efficacy of mRNA vaccines
Generation of an inflammatory niche in an injectable hydrogel depot through recruitment of key immune cells improves efficacy of mRNA vaccines Open
Messenger RNA (mRNA) delivered in lipid nanoparticles (LNPs) rose to the forefront of vaccine candidates during the COVID-19 pandemic due in part to scalability, adaptability, and potency. Yet there remain critical areas for improvements o…
View article: Defining Structure-Function Relationships of Amphiphilic Excipients Enables Rational Design of Ultra-Stable Biopharmaceuticals
Defining Structure-Function Relationships of Amphiphilic Excipients Enables Rational Design of Ultra-Stable Biopharmaceuticals Open
Summary Biopharmaceuticals are the fastest growing class of drugs in the healthcare industry, but their global reach is severely limited by their propensity for rapid aggregation. Currently, surfactant excipients such as polysorbates and p…
View article: Label-Free Composition Analysis of Supramolecular Polymer – Nanoparticle Hydrogels by Reversed-Phase Liquid Chromatography Coupled with a Charged Aerosol Detector
Label-Free Composition Analysis of Supramolecular Polymer – Nanoparticle Hydrogels by Reversed-Phase Liquid Chromatography Coupled with a Charged Aerosol Detector Open
Supramolecular hydrogels formed through polymer-nanoparticle interactions are promising biocompatible materials for translational medicines. This class of hydrogels exhibits shear-thinning behavior and rapid recovery of mechanical properti…
View article: A Regimen Compression Strategy for Commercial Vaccines Leveraging an Injectable Hydrogel Depot Technology for Sustained Vaccine Exposure
A Regimen Compression Strategy for Commercial Vaccines Leveraging an Injectable Hydrogel Depot Technology for Sustained Vaccine Exposure Open
Equitable global access to vaccines requires overcoming challenges associated with complex immunization schedules and their associated economic burdens that hinder delivery in under‐resourced environments. The rabies vaccine, for example, …
View article: A regimen compression strategy for commercial vaccines leveraging an injectable hydrogel depot technology for sustained vaccine exposure
A regimen compression strategy for commercial vaccines leveraging an injectable hydrogel depot technology for sustained vaccine exposure Open
Equitable global access to vaccines requires we overcome challenges associated with complex immunization schedules and their associated economic burdens that hinder delivery in under resourced environments. The rabies vaccine, for example,…
View article: A Swimming Rheometer: Self-propulsion of a freely-suspended swimmer enabled by viscoelastic normal stresses
A Swimming Rheometer: Self-propulsion of a freely-suspended swimmer enabled by viscoelastic normal stresses Open
Self-propulsion at low Reynolds number is notoriously restricted, a concept that is commonly known as the "scallop theorem". Here we present a truly self-propelled swimmer (force- and torque- free) that, while unable to swim in a Newtonian…
View article: In Situ Direct Laser Writing of 3D Graphene‐Laden Microstructures (Adv. Mater. Technol. 8/2021)
In Situ Direct Laser Writing of 3D Graphene‐Laden Microstructures (Adv. Mater. Technol. 8/2021) Open
3D Nanoprinting In article number 2100222, Ryan D. Sochol and colleagues introduce strategies for 3D nanoprinting graphene-laden materials to enable the integration of geometrically sophisticated microelectronics with microfluidic systems.…