Noah Lampl
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View article: Therapeutic 6-thio-deoxyguanosine inhibits telomere elongation in cancer cells by inducing a non-productive stalled telomerase complex
Therapeutic 6-thio-deoxyguanosine inhibits telomere elongation in cancer cells by inducing a non-productive stalled telomerase complex Open
Most cancers upregulate the telomere lengthening enzyme telomerase to achieve unlimited cell division. How chemotherapeutic nucleoside 6-thio-2’-deoxyguanosine (6-thio-dG) targets telomerase to inhibit telomere maintenance in cancer cells …
View article: Progressive Remodeling of Global Protein Interaction Networks in a Mouse Model of Tauopathy
Progressive Remodeling of Global Protein Interaction Networks in a Mouse Model of Tauopathy Open
SUMMARY Neurodegenerative disease is marked not just by loss of proteins or cells, but by dynamic rewiring of macromolecular interaction networks that precede and drive pathology. Here, we present the first temporally resolved, systems-sca…
View article: Chemotherapeutic 6-thio-2’-deoxyguanosine selectively targets and inhibits telomerase by inducing a non-productive telomere-bound telomerase complex
Chemotherapeutic 6-thio-2’-deoxyguanosine selectively targets and inhibits telomerase by inducing a non-productive telomere-bound telomerase complex Open
Most cancers upregulate the telomere lengthening enzyme telomerase to achieve unlimited cell division. How chemotherapeutic nucleoside 6-thio-2’-deoxyguanosine (6-thio-dG) targets telomerase to inhibit telomere maintenance in cancer cells …
View article: Proteomic and phosphoproteomic identified structural and functional changes in the aorta associate with age-dependent hypertension in male Sprague-Dawley rats
Proteomic and phosphoproteomic identified structural and functional changes in the aorta associate with age-dependent hypertension in male Sprague-Dawley rats Open
The mechanisms of age-dependent hypertension remain unclear. Male Sprague-Dawley rats develop age-dependent hypertension and increased sympathetic outflow to the vasculature. Age-dependent hypertension involves significant alterations in t…
View article: Beyond Glycolysis: Aldolase A Is a Novel Effector in Reelin-Mediated Dendritic Development
Beyond Glycolysis: Aldolase A Is a Novel Effector in Reelin-Mediated Dendritic Development Open
Reelin, a secreted glycoprotein, plays a crucial role in guiding neocortical neuronal migration, dendritic outgrowth and arborization, and synaptic plasticity in the adult brain. Reelin primarily operates through the canonical lipoprotein …
View article: Corrigendum: Integrated metabolomics and proteomics reveal biomarkers associated with hemodialysis in end-stage kidney disease
Corrigendum: Integrated metabolomics and proteomics reveal biomarkers associated with hemodialysis in end-stage kidney disease Open
[This corrects the article DOI: 10.3389/fphar.2023.1243505.].
View article: Beyond Glycolysis: Aldolase A is a Novel Effector in Reelin Mediated Dendritic Development
Beyond Glycolysis: Aldolase A is a Novel Effector in Reelin Mediated Dendritic Development Open
Reelin, a secreted glycoprotein, plays a crucial role in guiding neocortical neuronal migration, dendritic outgrowth and arborization, and synaptic plasticity in the adult brain. Reelin primarily operates through the canonical lipoprotein …
View article: Integrated metabolomics and proteomics reveal biomarkers associated with hemodialysis in end-stage kidney disease
Integrated metabolomics and proteomics reveal biomarkers associated with hemodialysis in end-stage kidney disease Open
Background: We hypothesize that the poor survival outcomes of end-stage kidney disease (ESKD) patients undergoing hemodialysis are associated with a low filtering efficiency and selectivity. The current gold standard criteria using single …
View article: PANAMA enabled high sensitivity dual nanoflow LC/MS metabolomics and proteomics analysis
PANAMA enabled high sensitivity dual nanoflow LC/MS metabolomics and proteomics analysis Open
Summary High sensitivity nanoflow liquid chromatography (nLC) is seldom employed in untargeted metabolomics because current sample preparation techniques are inefficient to prevent nanocapillary column performance degradation. Here, we des…