Noah Moruzzi
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View article: Metabolic Profiling Reveals a Glycolytic Shift and an <scp>IRG1</scp> /Itaconate/ <scp>NF2L2</scp> Axis Regulating Neurotoxic Oxidative Stress in Inflammatory Microglia
Metabolic Profiling Reveals a Glycolytic Shift and an <span>IRG1</span> /Itaconate/ <span>NF2L2</span> Axis Regulating Neurotoxic Oxidative Stress in Inflammatory Microglia Open
Polar metabolic profiling, as well as bioenergetic assays, were used to characterize microglial responses to lipopolysaccharide, which induces a pro‐inflammatory state, and interleukin‐4, which is associated with an anti‐inflammatory pheno…
View article: Metabolic Profiling of Distinct <i>TP53</i>-Mutant Esophageal Adenocarcinoma Models Reveals Different Bioenergetic Dependencies.
Metabolic Profiling of Distinct <i>TP53</i>-Mutant Esophageal Adenocarcinoma Models Reveals Different Bioenergetic Dependencies. Open
Esophageal adenocarcinoma (EAC) is a highly aggressive malignancy with rising incidence and poor prognosis. TP53, previously identified as the most frequently mutated gene in EAC in our studies, plays a central role in tumor suppression an…
View article: Survival and Proliferation of Activated Hepatic Stellate Cells Requires REST
Survival and Proliferation of Activated Hepatic Stellate Cells Requires REST Open
The activation of hepatic stellate cells (HSCs) is a key driver of liver fibrosis and inflammation in metabolic dysfunction-associated steatotic liver disease (MASLD). Targeting activated HSCs has shown promise in preventing liver fibrosis…
View article: In Vivo Imaging of Liver Spheroids Engrafted in the Anterior Chamber of the Mouse Eye
In Vivo Imaging of Liver Spheroids Engrafted in the Anterior Chamber of the Mouse Eye Open
Biomedical studies of the liver in mammals are hindered by the lack of methods for in vivo noninvasive longitudinal imaging at cellular resolution. Until now, optical imaging of the liver in situ is possible by intravital imaging, which of…
View article: Ruxolitinib: A new hope for ventilator‐induced diaphragm dysfunction
Ruxolitinib: A new hope for ventilator‐induced diaphragm dysfunction Open
Aim Mechanical ventilation (MV) results in diminished diaphragm size and strength, termed ventilator‐induced diaphragm dysfunction (VIDD). VID increases dependence, prolongs weaning, and increases discharge mortality rates. The Janus kinas…
View article: ATF4 orchestrates IL-1α-induced senescence in adult neural stem cells
ATF4 orchestrates IL-1α-induced senescence in adult neural stem cells Open
Adult neural stem cells (NSC) are a potential source for the regeneration of damaged tissue during neuropathological conditions, but much remains unexplored. In an attempt to study the influence of neuroinflammation on NSCs, we generated a…
View article: Intraocular liver spheroids for non-invasive high-resolution in vivo monitoring of liver cell function
Intraocular liver spheroids for non-invasive high-resolution in vivo monitoring of liver cell function Open
Longitudinal monitoring of liver function in vivo is hindered by the lack of high-resolution non-invasive imaging techniques. Using the anterior chamber of the mouse eye as a transplantation site, we have established a platform for longitu…
View article: Editorial: Mitochondrial bioenergetics impairments in genetic and metabolic diseases
Editorial: Mitochondrial bioenergetics impairments in genetic and metabolic diseases Open
EDITORIAL article Front. Physiol., 02 June 2023Sec. Metabolic Physiology Volume 14 - 2023 | https://doi.org/10.3389/fphys.2023.1228926
View article: Drp1 Overexpression Decreases Insulin Content in Pancreatic MIN6 Cells
Drp1 Overexpression Decreases Insulin Content in Pancreatic MIN6 Cells Open
Mitochondrial dynamics and bioenergetics are central to glucose-stimulated insulin secretion by pancreatic beta cells. Previously, we demonstrated that a disturbance in glucose-invoked fission impairs insulin secretion by compromising gluc…
View article: Mitochondrial impairment and intracellular reactive oxygen species alter primary cilia morphology
Mitochondrial impairment and intracellular reactive oxygen species alter primary cilia morphology Open
Primary cilia have recently emerged as cellular signaling organelles. Their homeostasis and function require a high amount of energy. However, how energy depletion and mitochondria impairment affect cilia have barely been addressed. We fir…
View article: Enhanced metabolism and negative regulation of ER stress support higher erythropoietin production in HEK293 cells
Enhanced metabolism and negative regulation of ER stress support higher erythropoietin production in HEK293 cells Open
Recombinant protein production can cause severe stress on cellular metabolism, resulting in limited titer and product quality. To investigate cellular and metabolic characteristics associated with these limitations, we compare HEK293 clone…
View article: Insulin Receptor Isoforms in Physiology and Metabolic Disease
Insulin Receptor Isoforms in Physiology and Metabolic Disease Open
Insulin receptors (IRs) are ubiquitously expressed and essential for all cell types. Their signaling cascades are connected to key pathways involved in cell metabolism, proliferation, and differentiation, amongst others. Thus, dysregulatio…
View article: Diversity of respiratory parameters and metabolic adaptation to low oxygen tension in mesenchymal stromal cells
Diversity of respiratory parameters and metabolic adaptation to low oxygen tension in mesenchymal stromal cells Open
In contrast to adult MSCs, fetal MSCs displayed similar respiration and aerobic glycolysis at different O2 culture concentrations during expansion. Adult MSCs adjusted their respiration to glycolytic activities, depending on the culture co…
View article: Tissue‐specific expression of insulin receptor isoforms in obesity/type 2 diabetes mouse models
Tissue‐specific expression of insulin receptor isoforms in obesity/type 2 diabetes mouse models Open
The two insulin receptor (IR) isoforms IR‐A and IR‐B are responsible for the pleiotropic actions of insulin and insulin‐like growth factors. Consequently, changes in IR isoform expression and in the bioavailability of their ligands will im…
View article: Lowering apolipoprotein CIII protects against high-fat diet–induced metabolic derangements
Lowering apolipoprotein CIII protects against high-fat diet–induced metabolic derangements Open
Diet-induced obesity, fatty liver, and type 2 diabetes are prevented by lowering apoCIII.
View article: Platelet factor 4 enhances CD4+ T effector memory cell responses via Akt‐PGC1α‐TFAM signaling‐mediated mitochondrial biogenesis
Platelet factor 4 enhances CD4+ T effector memory cell responses via Akt‐PGC1α‐TFAM signaling‐mediated mitochondrial biogenesis Open
Platelets enhance CD4+ T cell responses of Tem cells through PF4-dependent and Akt-PGC1α-TFAM signaling-mediated mitochondrial biogenesis. Hence, PF4 may be a promising intervention target of platelet-regulated immune responses.
View article: miR‐31 regulates energy metabolism and is suppressed in T cells from patients with Sjögren's syndrome
miR‐31 regulates energy metabolism and is suppressed in T cells from patients with Sjögren's syndrome Open
Systemic autoimmune diseases are characterized by the overexpression of type I IFN stimulated genes, and accumulating evidence indicate a role for type I IFNs in these diseases. However, the underlying mechanisms for this are still poorly …
View article: Diet‐induced β‐cell insulin resistance results in reversible loss of functional β‐cell mass
Diet‐induced β‐cell insulin resistance results in reversible loss of functional β‐cell mass Open
Although convincing in genetic models, the relevance of β‐cell insulin resistance in diet‐induced type 2 diabetes (T2DM) remains unclear. Exemplified by diabetes‐prone, male, C57B1/6J mice being fed different combinations of Western‐style …
View article: Interplay between mitochondria, primary cilium, diabetes and its complications
Interplay between mitochondria, primary cilium, diabetes and its complications Open
Diabetes is one of the major health problems of the 21st century. Dysfunction of the insulin secreting pancreatic β-cell together with insulin resistance is central to the pathogenesis of type 2 diabetes mellitus (T2DM). The cause of the d…