Noah Salama
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Time-resolved transcriptomics reveals new integrin dynamics upon T cell tissue entry 3198 Open
Description Type 1 T helper (Th1) cells must navigate varied tissue landscapes to find sites of infection. To enter inflamed tissues, Th1 cells must traffic through the blood, traverse the vascular endothelium, then encounter a complex int…
View article: MON-740 Abaloparatide Increases Bone Marrow Stromal Cells And Decreases Features Of Hematopoietic Aging In Old Male Mice
MON-740 Abaloparatide Increases Bone Marrow Stromal Cells And Decreases Features Of Hematopoietic Aging In Old Male Mice Open
Disclosure: R. Lakony: None. N. Vdovichenko: None. Y. Esaki: None. A. Tyrlik: None. Z. Jin: None. J. Zhang: None. C. Caballero: None. S. Patel: None. E.R. Quarato: None. N.A. Salama: None. Y. Kawano: None. L. LaMere: None. J.L. Liesveld: N…
Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis Open
Aging is characterized by a decline in the functionality and number of stem cells across the organism. In this study, we uncovered a mechanism by which systemic inflammation drives muscle stem cell (MuSC) aging through epigenetic erosion. …
Blocking LIF and PD-L1 enhances the antitumor efficacy of SBRT in murine PDAC models Open
Background Recent preclinical and clinical data suggest that leukemia inhibitory factor (LIF) is a potential target for various tumor types including pancreatic ductal adenocarcinoma as LIF is involved in multiple protumor processes includ…
View article: Monocytes/macrophages contamination disrupts functional and transcriptional characteristics of murine bone marrow- and bone-derived stromal cells
Monocytes/macrophages contamination disrupts functional and transcriptional characteristics of murine bone marrow- and bone-derived stromal cells Open
Stromal cells are critical regulators of hematopoietic stem/progenitor cells and skeletal homeostasis. Although precise systems for functional analysis are critical to investigate mechanistically bone and bone marrow (BM)-derived stromal c…
Integrating IL-12 mRNA nanotechnology with SBRT eliminates T cell exhaustion in preclinical models of pancreatic cancer Open
Pronounced T cell exhaustion characterizes immunosuppressive tumors, with the tumor microenvironment (TME) employing multiple mechanisms to elicit this suppression. Traditional immunotherapies, such as immune checkpoint blockade, often fai…
Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis. Open
Aging is associated with a decline in stem cell functionality and number across the organism. In this study, we aimed to further unravel Muscle Stem Cells (MuSCs) aging by assessing how systemic factors influence MuSC fate decisions throug…
Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis. Open
Aging is associated with a decline in stem cell functionality and number across the organism. In this study, we aimed to further unravel Muscle Stem Cells (MuSCs) aging by assessing how systemic factors influence MuSC fate decisions throug…
Local Delivery of SBRT and IL12 by mRNA Technology Overcomes Immunosuppressive Barriers to Eliminate Pancreatic Cancer Open
The immunosuppressive milieu in pancreatic cancer (PC) is a significant hurdle to treatments, resulting in survival statistics that have barely changed in 5 decades. Here we present a combination treatment consisting of stereotactic body r…
View article: Isocitrate Dehydrogenase 2 Mutation Allows Myeloid Differentiation but Impairs Bone Marrow Macrophage Polarization and Function Via Metabolic Dysregulation
Isocitrate Dehydrogenase 2 Mutation Allows Myeloid Differentiation but Impairs Bone Marrow Macrophage Polarization and Function Via Metabolic Dysregulation Open
Isocitrate dehydrogenase 2 (IDH2) mutations, while less common than other mutations associated with myelodysplastic syndromes (MDS), are also found in clonal hematopoiesis and are associated with increased risk of transformation to leukemi…
View article: Myelodysplastic syndromes disable support of human hematopoietic stem and progenitor cells by CD271, VCAM- 1 and CD146 expressing marrow niche cells
Myelodysplastic syndromes disable support of human hematopoietic stem and progenitor cells by CD271, VCAM- 1 and CD146 expressing marrow niche cells Open
SUMMARY Mesenchymal stem/stromal cells (MSCs) within the bone marrow microenvironment (BMME) support normal hematopoietic stem and progenitor cells (HSPCs). However, the heterogeneity of human MSCs has limited the understanding of their co…
Long-term persistence of viral RNA and inflammation in the CNS of macaques exposed to aerosolized Venezuelan equine encephalitis virus Open
Venezuelan equine encephalitis virus (VEEV) is a positively-stranded RNA arbovirus of the genus Alphavirus that causes encephalitis in humans. Cynomolgus macaques are a relevant model of the human disease caused by VEEV and are useful in e…
Long-term persistence of viral RNA and inflammation in the CNS of macaques exposed to aerosolized Venezuelan equine encephalitis virus Open
Venezuelan equine encephalitis virus (VEEV) is a positively-stranded RNA arbovirus of the genus Alphavirus that causes encephalitis in humans. Cynomolgus macaques are a relevant model of the human disease caused by VEEV and are useful in e…
Physiological and immunological changes in the brain associated with lethal eastern equine encephalitis virus in macaques Open
Aerosol exposure to eastern equine encephalitis virus (EEEV) can trigger a lethal viral encephalitis in cynomolgus macaques which resembles severe human disease. Biomarkers indicative of central nervous system (CNS) infection by the virus …
Analysis of peripheral immune responses for the development of an encephalitis non-human primate animal model for new world alphaviruses Open
The New World alphaviruses eastern equine encephalitis virus (EEEV), Venezuelan equine encephalitis virus (VEEV), and western equine encephalitis virus (WEEV) are all mosquito-borne pathogens originating in North and South America. All thr…