Nobuhiko Yamauchi
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View article: Impact of <i>NRAS</i> mutation on efficacy of triplet induction therapy in newly diagnosed multiple myeloma
Impact of <i>NRAS</i> mutation on efficacy of triplet induction therapy in newly diagnosed multiple myeloma Open
View article: Odronextamab monotherapy in patients with relapsed/refractory diffuse large B cell lymphoma: primary efficacy and safety analysis in phase 2 ELM-2 trial
Odronextamab monotherapy in patients with relapsed/refractory diffuse large B cell lymphoma: primary efficacy and safety analysis in phase 2 ELM-2 trial Open
View article: MMP3 mediates E2-induced bovine endometrial cell proliferation by releasing HB-EGF
MMP3 mediates E2-induced bovine endometrial cell proliferation by releasing HB-EGF Open
Cyclic cell proliferation and endometrial remodeling during the estrous cycle are important for maintaining normal endometrial function. However, the regulatory mechanisms underlying this cell proliferation have not yet been elucidated. In…
View article: Current development of chimeric antigen receptor T‐cell therapy for diffuse large B‐cell lymphoma and high‐grade B‐cell lymphoma
Current development of chimeric antigen receptor T‐cell therapy for diffuse large B‐cell lymphoma and high‐grade B‐cell lymphoma Open
Chimeric antigen receptor (CAR) T‐cell therapy has become a commercially available treatment option for relapsed or refractory (r/r) diffuse large B‐cell lymphoma (DLBCL) with two or more lines of prior therapies, and recently for high‐ris…
View article: Complex karyotype determined using conventional cytogenetic analysis is a poor prognostic factor in patients with multiple myeloma
Complex karyotype determined using conventional cytogenetic analysis is a poor prognostic factor in patients with multiple myeloma Open
High-risk cytogenetic abnormalities (HRCAs) influence the prognosis of multiple myeloma (MM). However, additional cytogenetic aberrations can lead to poor outcomes. This study aimed to clarify whether HRCAs and additional chromosomal abnor…
View article: Impact of TKI Switching, Reduction, and Discontinuation on Cardiovascular Events in cml patients
Impact of TKI Switching, Reduction, and Discontinuation on Cardiovascular Events in cml patients Open
The development of tyrosine kinase inhibitors (TKIs) has dramatically improved the treatment outcomes of the chronic myelogenous leukemia-chronic phase (CML-CP). However, cardiovascular events (CVEs), such as hypertension, peripheral arter…
View article: P1106: CLINICAL OUTCOME OF PATIENTS WITH LOCALIZED PRIMARY GASTRIC MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA: LONG-TERM FOLLOW-UP RESULTS FROM A SINGLE-INSTITUTION OBSERVATIONAL STUDY.
P1106: CLINICAL OUTCOME OF PATIENTS WITH LOCALIZED PRIMARY GASTRIC MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA: LONG-TERM FOLLOW-UP RESULTS FROM A SINGLE-INSTITUTION OBSERVATIONAL STUDY. Open
Topic: 18. Indolent and mantle-cell non-Hodgkin lymphoma - Clinical Background: The natural history of localized primary gastric mucosa-associated lymphoid tissue (PG-MALT) lymphoma has been reported to follow an indolent course. The eradi…
View article: PB2317: POLATUZUMAB VEDOTIN PLUS BENDAMUSTINE AND RITUXIMAB THERAPY IN RELAPSED OR REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA: A SINGLE-INSTITUTION EXPERIENCE FOCUSING ON DETAILED ASSESSMENT OF TOXICITIES
PB2317: POLATUZUMAB VEDOTIN PLUS BENDAMUSTINE AND RITUXIMAB THERAPY IN RELAPSED OR REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA: A SINGLE-INSTITUTION EXPERIENCE FOCUSING ON DETAILED ASSESSMENT OF TOXICITIES Open
Topic: 19. Aggressive Non-Hodgkin lymphoma - Clinical Background: Polatuzumab vedotin combined with bendamustine and rituximab (pola-BR) therapy has shown efficacy for patients with relapsed or refractory diffuse large B cell lymphoma (DLB…
View article: Clinical utility of genomic profiling of <scp>AML</scp> using paraffin‐embedded bone marrow clots: <scp>HM‐SCREEN‐Japan</scp> 01
Clinical utility of genomic profiling of <span>AML</span> using paraffin‐embedded bone marrow clots: <span>HM‐SCREEN‐Japan</span> 01 Open
Next‐generation sequencing of AML has identified specific genetic mutations in AML patients. Hematologic Malignancies (HM)‐SCREEN‐Japan 01 is a multicenter study to detect actionable mutations using paraffin‐embedded bone marrow (BM) clot …
View article: Final analysis of randomized phase II study optimizing melphalan, prednisolone, bortezomib in multiple myeloma (<scp>JCOG1105</scp>)
Final analysis of randomized phase II study optimizing melphalan, prednisolone, bortezomib in multiple myeloma (<span>JCOG1105</span>) Open
We conducted a randomized phase II study to determine a more promising modified MPB regimen for TI-NDMM (JCOG1105, jRCTs031180097). The primary analysis in JCOG1105 revealed that Arm A (known as PETHEMA/GEM05 MPB) showed a higher CR rate a…
View article: Molecular Classification and Overcoming Therapy Resistance for Acute Myeloid Leukemia with Adverse Genetic Factors
Molecular Classification and Overcoming Therapy Resistance for Acute Myeloid Leukemia with Adverse Genetic Factors Open
The European LeukemiaNet (ELN) criteria define the adverse genetic factors of acute myeloid leukemia (AML). AML with adverse genetic factors uniformly shows resistance to standard chemotherapy and is associated with poor prognosis. Here, w…
View article: Feasibility and clinical utility of comprehensive genomic profiling of hematological malignancies
Feasibility and clinical utility of comprehensive genomic profiling of hematological malignancies Open
Identification of genetic alterations through next‐generation sequencing (NGS) can guide treatment decision‐making by providing information on diagnosis, therapy selection, and prognostic stratification in patients with hematological malig…
View article: FIRST‐IN‐HUMAN STUDY OF THE EZH1 AND EZH2 DUAL INHIBITOR VALEMETOSTAT TOSYLATE (DS‐3201B) IN PATIENTS WITH RELAPSED OR REFRACTORY NON‐HODGKIN LYMPHOMAS
FIRST‐IN‐HUMAN STUDY OF THE EZH1 AND EZH2 DUAL INHIBITOR VALEMETOSTAT TOSYLATE (DS‐3201B) IN PATIENTS WITH RELAPSED OR REFRACTORY NON‐HODGKIN LYMPHOMAS Open
Introduction: Enhancer of zeste homolog 2 (EZH2) and its close homolog, EZH1, catalyze the attachment of 3 methyl groups to histone H3 at lysine 27. Altered EZH2 expression is implicated in the etiology of non‐Hodgkin lymphomas (NHLs). Val…
View article: Brentuximab vedotin maintenance after autologous stem cell transplantation for refractory gray zone lymphoma with long‑term remission
Brentuximab vedotin maintenance after autologous stem cell transplantation for refractory gray zone lymphoma with long‑term remission Open
Gray zone lymphoma (GZL) is a rare type of B-cell lymphoma characterized by features of both diffuse large B-cell lymphoma and classical Hodgkin lymphoma (cHL). The prognosis of GZL is poorer than that of cHL and mediastinal large B-cell l…
View article: Molecular remission after combination therapy with blinatumomab and ponatinib with relapsed/refractory Philadelphia chromosome-positive acute lymphocytic leukemia: two case reports
Molecular remission after combination therapy with blinatumomab and ponatinib with relapsed/refractory Philadelphia chromosome-positive acute lymphocytic leukemia: two case reports Open
View article: A randomized phase 2/3 study of R-CHOP vs CHOP combined with dose-dense rituximab for DLBCL: the JCOG0601 trial
A randomized phase 2/3 study of R-CHOP vs CHOP combined with dose-dense rituximab for DLBCL: the JCOG0601 trial Open
Rituximab plus cyclophosphamide-doxorubicin-vincristine-prednisone (R-CHOP) is the standard of care for untreated diffuse large B-cell lymphoma (DLBCL). However, the schedule for rituximab administration has not been optimized. To compare …
View article: Prophylactic antiviral therapy for hepatitis B virus surface antigen‐positive patients with diffuse large B‐cell lymphoma treated with rituximab‐containing chemotherapy
Prophylactic antiviral therapy for hepatitis B virus surface antigen‐positive patients with diffuse large B‐cell lymphoma treated with rituximab‐containing chemotherapy Open
We conducted a nationwide retrospective analysis of 116 hepatitis B virus (HBV) surface antigen (HBsAg)‐positive patients with diffuse large B‐cell lymphoma (DLBCL) and 278 HBsAg‐negative patients with DLBCL, as a control cohort, who recei…
View article: Emerging Mitochondria-Associated Molecular Target Therapies for Acute Myeloid Leukemia
Emerging Mitochondria-Associated Molecular Target Therapies for Acute Myeloid Leukemia Open
The era of precision medicine for acute myeloid leukemia (AML) has arrived, and it is extremely important to detect actionable mutations relevant to treatment-related decision-making. However, the percentage of actionable mutations found i…
View article: The role of local radiotherapy following rituximab‐containing chemotherapy in patients with transformed indolent B‐cell lymphoma
The role of local radiotherapy following rituximab‐containing chemotherapy in patients with transformed indolent B‐cell lymphoma Open
Objectives This study aimed to evaluate the outcomes of local radiotherapy (LRT) in patients with histologic transformation (HT) following rituximab‐containing chemotherapy. Methods We retrospectively analysed 92 patients with biopsy‐confi…
View article: Transformation Scoring System (TSS): A new assessment index for clinical transformation of follicular lymphoma
Transformation Scoring System (TSS): A new assessment index for clinical transformation of follicular lymphoma Open
Although histologic analysis is the gold standard for diagnosing follicular lymphoma (FL) transformation, many patients are diagnosed with transformation by clinical factors as biopsy specimens often cannot be obtained. Despite the frequen…
View article: The critical role of CD4+ T cells in PD-1 blockade against MHC-II–expressing tumors such as classic Hodgkin lymphoma
The critical role of CD4+ T cells in PD-1 blockade against MHC-II–expressing tumors such as classic Hodgkin lymphoma Open
Classic Hodgkin lymphoma (cHL) responds markedly to PD-1 blockade therapy, and the clinical responses are reportedly dependent on expression of major histocompatibility complex class II (MHC-II). This dependence is different from other sol…
View article: R‐CHOP‐14 versus R‐CHOP‐14/CHASER for upfront autologous transplantation in diffuse large B‐cell lymphoma: JCOG0908 study
R‐CHOP‐14 versus R‐CHOP‐14/CHASER for upfront autologous transplantation in diffuse large B‐cell lymphoma: JCOG0908 study Open
The efficiency of upfront consolidation with high‐dose chemotherapy/autologous stem‐cell transplantation (HDCT/ASCT) for newly diagnosed high‐risk diffuse large B‐cell lymphoma (DLBCL) may be influenced by induction chemotherapy. To select…
View article: Immune-Checkpoint Blockade Therapy in Lymphoma
Immune-Checkpoint Blockade Therapy in Lymphoma Open
Tumor cells use immune-checkpoint pathways to evade the host immune system and suppress immune cell function. These cells express programmed cell-death protein 1 ligand 1 (PD-L1)/PD-L2, which bind to the programmed cell-death protein 1 (PD…
View article: Effect of Unsaturated Fatty Acids Supplementation on Productive and Reproductive Performance of Ram Lambs
Effect of Unsaturated Fatty Acids Supplementation on Productive and Reproductive Performance of Ram Lambs Open
The objective of this study was to determine the effect of dietary unsaturated fatty acids supplementation on productive and reproductive performance of ram lambs. In this study, 15 crossbred ram lambs (½Finnish × ½Rhamni) at 7 months of a…
View article: Analysis of differentially expressed genes and the promoters in bovine endometrium throughout estrus cycle and early pregnancy
Analysis of differentially expressed genes and the promoters in bovine endometrium throughout estrus cycle and early pregnancy Open
Endometrial gene expression is primarily regulated by the ovarian steroids and pregnancy recognition factors. This study was aimed to characterize differential expression genes (DEGs) in bovine endometrium together with the analysis of the…
View article: The Effect of Integrated Play Therapy on Self–Expression and Depression in Elderly Women Living Alone in Rural Areas
The Effect of Integrated Play Therapy on Self–Expression and Depression in Elderly Women Living Alone in Rural Areas Open
The aim of this study is to investigate the effects of an integrated play therapy program on self–expression, depression, and psychosocial well–being among elderly women who live alone in rural areas. The study was conducted on a group of …
View article: Chronic myeloid leukemia stem cells and molecular target therapies for overcoming resistance and disease persistence
Chronic myeloid leukemia stem cells and molecular target therapies for overcoming resistance and disease persistence Open
View article: Protective Effect of Trehalose on Canine Spermatozoa in Cryopreservation
Protective Effect of Trehalose on Canine Spermatozoa in Cryopreservation Open
Cryopreservation of canine spermatozoa allows to preserve male genetic materials and contributes to conserve genetic materials of superior males or extinct animals in breeding management by using the frozen spermatozoa at time needed. Howe…
View article: Production of Female Bovine Embryos with Sperm Sorted by Magnetic Activated Cell Sorting
Production of Female Bovine Embryos with Sperm Sorted by Magnetic Activated Cell Sorting Open
Sperm sexing is an efficient mean to obtain offspring with desired male and female. For sexing bovine sperm, flow cytometry has been used as a practical method. However, sperm sorting equipments are fairly expensive and complicated. Recent…
View article: Donor cell-derived transient abnormal myelopoiesis as a specific complication of umbilical cord blood transplantation
Donor cell-derived transient abnormal myelopoiesis as a specific complication of umbilical cord blood transplantation Open