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View article: N-Cadherin-Mediated Epithelial–Mesenchymal Transition as a Prognostic Indicator in Canine Melanoma
N-Cadherin-Mediated Epithelial–Mesenchymal Transition as a Prognostic Indicator in Canine Melanoma Open
Canine melanoma is a relatively common and clinically significant neoplasm in veterinary oncology, with important prognostic implications. Epithelial–mesenchymal transition (EMT), associated with changes in cell adhesion and increased meta…
View article: FATORES PREDITIVOS DE LUXAÇÃO DE QUADRIL EM IDOSOS COM ARTROPLASTIA TOTAL DE QUADRIL
FATORES PREDITIVOS DE LUXAÇÃO DE QUADRIL EM IDOSOS COM ARTROPLASTIA TOTAL DE QUADRIL Open
Objetivo: avaliar os fatores preditivos de luxação de quadril em idosos com artroplastia total de quadril. Métodos: conduziu-se um estudo de revisão integrativa da literatura. Foram analisados artigos recuperados por meio das bases de dado…
View article: EDUCAÇÃO ALIMENTAR E NUTRICIONAL PARA PREVENÇÃO DA OBESIDADE INFANTIL
EDUCAÇÃO ALIMENTAR E NUTRICIONAL PARA PREVENÇÃO DA OBESIDADE INFANTIL Open
A obesidade é uma doença e fator de riscos para inúmeras outras doenças, sendo a escola um cenário privilegiado juntamente aos serviços de atenção primária na configuração do Programa Saúde na Escola para seu enfrentamento. O objetivo do p…
View article: Chromatography and Mass Spectrometry: Evolving Techniques for Food Analysis
Chromatography and Mass Spectrometry: Evolving Techniques for Food Analysis Open
The assurance of food safety and quality is considered a worldwide concern due to its implications for public health [...]
View article: Analysis of the profile of colon and rectal neoplasia: hospital records of the National Cancer Institute José Alencar Gomes da Silva
Analysis of the profile of colon and rectal neoplasia: hospital records of the National Cancer Institute José Alencar Gomes da Silva Open
Objective: to analyze the profile of patients with colon and rectal cancer between 2018 and 2022 in Montes Claros, Minas Gerais State, Brazil. Methods: A descriptive study with a quantitative approach was carried out using data from patien…
View article: Exploiting the 5‐Amino‐11H‐Indolo[3,2‐c]isoquinoline Core to Achieve Better G‐Quadruplex Ligands for Cancer Therapy
Exploiting the 5‐Amino‐11H‐Indolo[3,2‐c]isoquinoline Core to Achieve Better G‐Quadruplex Ligands for Cancer Therapy Open
G‐quadruplexes (G4) are secondary structures that can form within guanine‐rich DNA sequences and have cell proliferation regulatory functions. Targeting DNA G4 structures has emerged as a promising anticancer therapy, highlighting the need…
View article: Diagnostic Challenges and Gram-Negative Pathogen Dominance in Early- and Late-Onset Neonatal Sepsis in Manila, Philippines: A Prospective Observational Study
Diagnostic Challenges and Gram-Negative Pathogen Dominance in Early- and Late-Onset Neonatal Sepsis in Manila, Philippines: A Prospective Observational Study Open
View article: Exploring Biosurfactants as Antimicrobial Approaches
Exploring Biosurfactants as Antimicrobial Approaches Open
Antibacterial resistance is one of the most important global threats to human health. Several studies have been performed to overcome this problem and infection-preventive approaches appear as promising solutions. Novel antimicrobial preve…
View article: Monoterpene indole alkaloids with anticancer activity from Tabernaemontana species
Monoterpene indole alkaloids with anticancer activity from Tabernaemontana species Open
Indole alkaloids, predominantly found in plants, are a large group of natural product-derived compounds characterized by a remarkable chemical diversity associated with significant biological properties. Among these, terpenoid indole alkal…
View article: Triterpenes Drug Delivery Systems, a Modern Approach for Arthritis Targeted Therapy
Triterpenes Drug Delivery Systems, a Modern Approach for Arthritis Targeted Therapy Open
Arthritis is a major cause of disability. Currently available anti-arthritic drugs, such as disease-modifying anti-rheumatic drugs (DMARDs), have serious side-effects associated with long-term use. Triterpenoids are natural products with k…
View article: Myrsinane-Type Diterpenes: A Comprehensive Review on Structural Diversity, Chemistry and Biological Activities
Myrsinane-Type Diterpenes: A Comprehensive Review on Structural Diversity, Chemistry and Biological Activities Open
Euphorbia species are important sources of polycyclic and macrocyclic diterpenes, which have been the focus of natural-product-based drug research due to their relevant biological properties, including anticancer, multidrug resistance reve…
View article: Placebo-Controlled Trial of Daily Oral Cannabidiol as Adjunctive Treatment for Cats with Chronic Gingivostomatitis
Placebo-Controlled Trial of Daily Oral Cannabidiol as Adjunctive Treatment for Cats with Chronic Gingivostomatitis Open
A placebo-controlled study evaluated the clinical efficacy and safety of a commercially available cannabidiol (CBD) oral formulation as an adjunctive treatment for pain management for feline chronic gingivostomatitis (FCGS). CBD was includ…
View article: 3D-printed biosurfactant-chitosan antibacterial coating for the prevention of silicone-based associated infections
3D-printed biosurfactant-chitosan antibacterial coating for the prevention of silicone-based associated infections Open
View article: Triterpenes as Potential Drug Candidates for Rheumatoid Arthritis Treatment
Triterpenes as Potential Drug Candidates for Rheumatoid Arthritis Treatment Open
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by joint inflammation, swelling and pain. Although RA mainly affects the joints, the disease can also have systemic implications. The presence of autoanti…
View article: Special Issue on Plant and Marine-Derived Natural Product Research in Drug Discovery: Strengths and Perspective
Special Issue on Plant and Marine-Derived Natural Product Research in Drug Discovery: Strengths and Perspective Open
For centuries, nature has been an inspirational source for the discovery of traditional remedies and drugs used in modern medicine [...]
View article: Comprehensive Two-Dimensional Gas Chromatography as a Powerful Strategy for the Exploration of Broas Volatile Composition
Comprehensive Two-Dimensional Gas Chromatography as a Powerful Strategy for the Exploration of Broas Volatile Composition Open
Broa is a Portuguese maize bread with characteristic sensory attributes that can only be achieved using traditional maize varieties. This study intends to disclose the volatile compounds that are mainly associated with the baking process o…
View article: C<sub>20</sub>-<i>nor</i>-Abietane and Three Abietane Diterpenoids from <i>Plectranthus mutabilis</i> Leaves as P-Glycoprotein Modulators
C<sub>20</sub>-<i>nor</i>-Abietane and Three Abietane Diterpenoids from <i>Plectranthus mutabilis</i> Leaves as P-Glycoprotein Modulators Open
In this study, a bioguided fractionation of Plectranthus mutabilis extract was performed by chromatographic methods. It yielded one new nor-abietane diterpene, mutabilol (1), and three known abietanes, coleon-U-quinone…
View article: Plant Terpenoids as Hit Compounds against Trypanosomiasis
Plant Terpenoids as Hit Compounds against Trypanosomiasis Open
Human African trypanosomiasis (sleeping sickness) and American trypanosomiasis (Chagas disease) are vector-borne neglected tropical diseases, caused by the protozoan parasites Trypanosoma brucei and Trypanosoma cruzi, respectively. These d…
View article: Editorial: Nature Inspired Protective Agents Against Oxidative Stress
Editorial: Nature Inspired Protective Agents Against Oxidative Stress Open
Oxidative stress is the result of an imbalance between pro-oxidant and antioxidant species at cellular 11 level, also defined as a lack in redox signaling and control. Despite small amounts of reactive oxygen 12 or nitrogen species (ROS an…
View article: Momordica balsamina: phytochemistry and pharmacological potential of a gifted species
Momordica balsamina: phytochemistry and pharmacological potential of a gifted species Open
View article: Shedding Light on the Volatile Composition of Broa, a Traditional Portuguese Maize Bread
Shedding Light on the Volatile Composition of Broa, a Traditional Portuguese Maize Bread Open
In Portugal, maize has been used for centuries to produce an ethnic bread called broa, employing traditional maize varieties, which are preferred by the consumers in detriment of commercial hybrids. In order to evaluate the maize volatiles…
View article: Improving nutritional quality of unripe tomato through fermentation by a consortium of yeast and lactic acid bacteria
Improving nutritional quality of unripe tomato through fermentation by a consortium of yeast and lactic acid bacteria Open
BACKGROUND Portugal is one of the main producers of industrial tomato and tomato paste, an important intermediate ingredient used in many added‐value foods. The tomato processing industry rigorously selects the fruits by colour during mech…
View article: A Newfangled Collagenase Inhibitor Topical Formulation Based on Ethosomes with Sambucus nigra L. Extract
A Newfangled Collagenase Inhibitor Topical Formulation Based on Ethosomes with Sambucus nigra L. Extract Open
Sambucus nigra L. (S. nigra) is a shrub widespread in Europe and western Asia, traditionally used in medicine, that has become popular in recent years as a potential source of a wide range of interesting bioactive compounds. The aim of the…
View article: Broa, an Ethnic Maize Bread, as a Source of Phenolic Compounds
Broa, an Ethnic Maize Bread, as a Source of Phenolic Compounds Open
Maize is an important source of phenolic compounds, specially hydroxycinnamic acids, which are widely known for their antioxidant activity and associated health benefits. However, these effects depend on their bioaccessibility, which is in…
View article: Preliminary Biological Activity Screening of Plectranthus spp. Extracts for the Search of Anticancer Lead Molecules
Preliminary Biological Activity Screening of Plectranthus spp. Extracts for the Search of Anticancer Lead Molecules Open
Plectranthus species (Lamiaceae) have been employed in traditional medicine and this is now validated by the presence of bioactive abietane-type diterpenoids. Herein, sixteen Plectranthus acetonic extracts were prepared by ultrasound-assis…
View article: Mid-Infrared Spectroscopy as a Valuable Tool to Tackle Food Analysis: A Literature Review on Coffee, Dairies, Honey, Olive Oil and Wine
Mid-Infrared Spectroscopy as a Valuable Tool to Tackle Food Analysis: A Literature Review on Coffee, Dairies, Honey, Olive Oil and Wine Open
Nowadays, food adulteration and authentication are topics of utmost importance for consumers, food producers, business operators and regulatory agencies. Therefore, there is an increasing search for rapid, robust and accurate analytical te…
View article: Further Evidence of Possible Therapeutic Uses of Sambucus nigra L. Extracts by the Assessment of the In Vitro and In Vivo Anti-Inflammatory Properties of Its PLGA and PCL-Based Nanoformulations
Further Evidence of Possible Therapeutic Uses of Sambucus nigra L. Extracts by the Assessment of the In Vitro and In Vivo Anti-Inflammatory Properties of Its PLGA and PCL-Based Nanoformulations Open
Sambucus nigra L. is widely used in traditional medicine with different applications. However, confirmative studies are strongly required. This study aimed to assess the biological activities of the S. nigra flower’s extract encapsulated i…
View article: Royleanone Derivatives From Plectranthus spp. as a Novel Class of P-Glycoprotein Inhibitors
Royleanone Derivatives From Plectranthus spp. as a Novel Class of P-Glycoprotein Inhibitors Open
Cancer is among the leading causes of death worldwide. One of the most challenging obstacles in cancer treatment is multidrug resistance (MDR). Overexpression of P-glycoprotein (P-gp) is associated with MDR. The growing incidence of cancer…
View article: Chemical Composition and Biological Activity of Diterpenoids from &lt;em&gt;Plectranthus mutabilis&lt;/em&gt;
Chemical Composition and Biological Activity of Diterpenoids from <em>Plectranthus mutabilis</em> Open
Despite the great development in human medicine, cancer is still a serious threat to public health and consequently, research on new anticancer agents should be continued. Natural products from medicinal plants (e.g., Plectranthus species)…
View article: Hydroxycinnamic Acids and Their Derivatives in Broa, a Traditional Ethnic Maize Bread
Hydroxycinnamic Acids and Their Derivatives in Broa, a Traditional Ethnic Maize Bread Open
Maize is one of the most interesting dietary sources of hydroxycinnamic acids, widely known for their beneficial health effects, namely antioxidant properties. This work aims to identify hydroxycinnamic acids and their derivatives in broa,…