Explanipedia

5-year follow-up of a fully implanted brain–computer interface in a spinal cord injury patient Open

Kevin Davis, Kimberley Wyse‐Sookoo, Fouzia Raza, Benyamin Meschede-Krasa, Noeline W. Prins , et al. · 2025

Spinal cord injury (SCI) affects over 250 000 individuals in the US. Brain–computer interfaces (BCIs) may improve quality of life by controlling external devices. Invasive intracortical BCIs have shown promise in clinical trials but degrad…

Differential modulation of the pedunculopontine nucleus with targeted subthalamic nucleus deep brain stimulation Open

Noeline W. Prins, Alex Doyle, Ming Lei, Edward M. Bello, Harshavardhan Yedady , et al. · 2025

Examining funders’ roles in responsible research and innovation of medical neurotechnology Open

Denis Larrivée, Jennifer French, Alberto Antonietti, Zach McKinney, Noeline W. Prins , et al. · 2024

Advances in medical neurotechnology (MNT) have the potential to improve the evaluation and management of conditions of the nervous system. Meanwhile, increasing concern over ethical questions and risks posed by these technologies has promp…

Brain-Computer interface control of stepping from invasive electrocorticography upper-limb motor imagery in a patient with quadriplegia Open

Iahn Cajigas, Kevin Davis, Noeline W. Prins, Sebastian Gallo, Jasim Naeem , et al. · 2023

Introduction: Most spinal cord injuries (SCI) result in lower extremities paralysis, thus diminishing ambulation. Using brain-computer interfaces (BCI), patients may regain leg control using neural signals that actuate assistive devices. H…

Monkeys playing video games lead to a paralysed man walking Open

Noeline W. Prins · 2022

Spinal cord injury (SCI) frequently results in complete, permanent paralysis. Although it is possible to reverse the effects of incomplete paralysis, complete paralysis effects are permanent. At present, there is no cure for SCI, but engin…

Design-development of an at-home modular brain–computer interface (BCI) platform in a case study of cervical spinal cord injury Open

Kevin Davis, Benyamin Meschede-Krasa, Iahn Cajigas, Noeline W. Prins, Charles Alver , et al. · 2022

Objective The objective of this study was to develop a portable and modular brain–computer interface (BCI) software platform independent of input and output devices. We implemented this platform in a case study of a subject with cervical s…

Implantable brain–computer interface for neuroprosthetic-enabled volitional hand grasp restoration in spinal cord injury Open

Iahn Cajigas, Kevin Davis, Benyamin Meschede-Krasa, Noeline W. Prins, Sebastian Gallo , et al. · 2021

Loss of hand function after cervical spinal cord injury severely impairs functional independence. We describe a method for restoring volitional control of hand grasp in one 21-year-old male subject with complete cervical quadriplegia (C5 A…

Chronic recordings from the marmoset motor cortex reveals modulation of neural firing and local field potentials overlap with macaques Open

Ramanamurthy Mylavarapu, Noeline W. Prins, Eric A. Pohlmeyer, Alden M. Shoup, Shubham Debnath , et al. · 2021

Objective.The common marmoset has been increasingly used in neural interfacing studies due to its smaller size, easier handling, and faster breeding compared to Old World non-human primate (NHP) species. While assessment of cortical…

Implantable Brain-Computer Interface for Volitional Hand Grasp in Spinal Cord Injury Open

Jonathan Jagid, Iahn Cajigas, Kevin Davis, Benyamin Meschede-Krasa, Noeline W. Prins , et al. · 2021

Loss of hand function after cervical spinal cord injury severely impairs functional independence. We describe a method for restoring volitional control of hand grasp in a subject with complete cervical quadriplegia (C5 ASIA Impairment Scal…

Spinal cord neural interfacing in common marmosets (<i>Callithrix jacchus</i>) Open

Noeline W. Prins, Ramanamurthy Mylavarapu, Alden M. Shoup, Shubham Debnath, Abhishek Prasad · 2019

Marmosets provide a good step between rodent and larger NHP models due to their small size, ease of handling, cognitive abilities, and similarities to other primate motor systems. The study shows the feasibility of recording spinal cord si…

A confidence metric for using neurobiological feedback in actor-critic reinforcement learning based brain-machine interfaces Open

Noeline W. Prins, Justin C. Sanchez, Abhishek Prasad · 2014

Brain-Machine Interfaces (BMIs) can be used to restore function in people living with paralysis. Current BMIs require extensive calibration that increase the set-up times and external inputs for decoder training that may be difficult to pr…

Using Reinforcement Learning to Provide Stable Brain-Machine Interface Control Despite Neural Input Reorganization Open

Eric A. Pohlmeyer, Babak Mahmoudi, Shijia Geng, Noeline W. Prins, Justin C. Sanchez · 2014

Brain-machine interface (BMI) systems give users direct neural control of robotic, communication, or functional electrical stimulation systems. As BMI systems begin transitioning from laboratory settings into activities of daily living, an…

The first conclusive evidence for the existence of energy-based texture mechanisms Open

Noeline W. Prins, F. A A Kingdom · 2010

Two classes of models have been proposed to account for the processing of texture modulations. In one class of model abstract representations such as feature or texton maps are assumed to underlie detection. In the second class of model te…

Orientation- and frequency-modulated textures at low depths of modulation are processed by off-orientation and off-frequency texture mechanisms Open

Noeline W. Prins, F. A. A. Kingdom · 2010

Intuitively it may seem likely that orientation-modulated (OM) and frequency-modulated (FM) textures are processed utilizing the first-order channels that are most responsive to the first-order (luminance) information contained within the …

Colour coding on visual displays Open

Noeline W. Prins · 1993

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