Andrea E. Tóth
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View article: Does Phototherapy Affect Ductus Arteriosus Closure in Preterm Infants ≤32 Weeks of Gestation, and Can We Influence This Through Chest Shielding? Review of the Literature and a Meta-Analysis
Does Phototherapy Affect Ductus Arteriosus Closure in Preterm Infants ≤32 Weeks of Gestation, and Can We Influence This Through Chest Shielding? Review of the Literature and a Meta-Analysis Open
Background: Persistency of patent ductus arteriosus is the main cardiac condition in the preterm population born before 32 completed weeks of gestation with possible short- and long-term hemodynamic disturbances leading to vast morbidity. …
View article: Serum Biomarkers in Patent Ductus Arteriosus in Preterm Infants: A Narrative Review
Serum Biomarkers in Patent Ductus Arteriosus in Preterm Infants: A Narrative Review Open
Background: Patent ductus arteriosus (PDA) in preterm infants presents a significant challenge in neonatal care, marked by ongoing debates about its definition, diagnosis, treatment options, and effects on patient outcomes. Plasma biomarke…
View article: Serum Biomarkers In Persistent Ductus Arteriosus In Preterm Infants: A Narrative Review
Serum Biomarkers In Persistent Ductus Arteriosus In Preterm Infants: A Narrative Review Open
Background: Patent ductus arteriosus (PDA) in preterm infants presents a significant challenge in neonatal care, marked by ongoing debates about its definition, diagnosis, treatment options, and effects on patient outcomes. Plasma biomarke…
View article: Non-surgical management of severe aplasia cutis congenita accompanied by a bone defect – a case study
Non-surgical management of severe aplasia cutis congenita accompanied by a bone defect – a case study Open
Background and objectives. Aplasia cutis congenita (ACC) is a rare developmental disorder that is not fully understood. It is part of a diverse group of conditions characterized by the congenital absence of the epidermis, dermis, and occas…
View article: SorLA in astrocytes regulates blood-brain barrier integrity
SorLA in astrocytes regulates blood-brain barrier integrity Open
The brain`s homeostasis depends heavily on the integrity of the blood-brain barrier (BBB). Astrocytes are an essential part of the BBB in modulating and maintaining the barrier properties of the brain endothelial cells (BECs). Despite deca…
View article: Sortilins in the blood-brain barrier: impact on barrier integrity
Sortilins in the blood-brain barrier: impact on barrier integrity Open
Sortilin was discovered in 1997 by Petersen and his colleagues. The single transmembrane receptor was isolated as a 95 kDa membrane glycoprotein by receptor-associated protein affinity chromatography and therefore initially named gp95. The…
View article: Sortilin regulates blood–brain barrier integrity
Sortilin regulates blood–brain barrier integrity Open
Brain homeostasis depends on the existence of the blood–brain barrier (BBB). Despite decades of research, the factors and signalling pathways for modulating and maintaining BBB integrity are not fully elucidated. Here, we characterise the …
View article: Characterization of a Primate Blood-Brain Barrier Co-Culture Model Prepared from Primary Brain Endothelial Cells, Pericytes and Astrocytes
Characterization of a Primate Blood-Brain Barrier Co-Culture Model Prepared from Primary Brain Endothelial Cells, Pericytes and Astrocytes Open
Culture models of the blood-brain barrier (BBB) are important research tools. Their role in the preclinical phase of drug development to estimate the permeability for potential neuropharmaceuticals is especially relevant. Since species dif…
View article: Cyclic Hypoxia Conditioning Alters the Content of Myoblast-Derived Extracellular Vesicles and Enhances Their Cell-Protective Functions
Cyclic Hypoxia Conditioning Alters the Content of Myoblast-Derived Extracellular Vesicles and Enhances Their Cell-Protective Functions Open
Remote ischemic conditioning (RIC) is a procedure that can attenuate ischemic-reperfusion injury by conducting brief cycles of ischemia and reperfusion in the arm or leg. Extracellular vesicles (EVs) circulating in the bloodstream can rele…
View article: SorCS2 deletion leads to altered neuronal lysosome activity
SorCS2 deletion leads to altered neuronal lysosome activity Open
Vps10p domain receptors are important for regulating intracellular protein sorting within the central nervous system and as such constitute risk factors for different brain pathologies. Here, we show that removal of SorCS2 leads to altered…
View article: Transport of a Peptide from Bovine αs1-Casein across Models of the Intestinal and Blood–Brain Barriers
Transport of a Peptide from Bovine αs1-Casein across Models of the Intestinal and Blood–Brain Barriers Open
The effect of food components on brain growth and development has attracted increasing attention. Milk has been shown to contain peptides that deliver important signals to the brains of neonates and infants. In order to reach the brain, mi…
View article: Common variants in glyoxalase I do not increase chronic pancreatitis risk
Common variants in glyoxalase I do not increase chronic pancreatitis risk Open
Common GLO1 variants do not increase chronic pancreatitis risk.
View article: The endo-lysosomal system of bEnd.3 and hCMEC/D3 brain endothelial cells
The endo-lysosomal system of bEnd.3 and hCMEC/D3 brain endothelial cells Open
Taken together our data identify differences in the trafficking network of brain endothelial cells, essentially mapping the endo-lysosomal system of in vitro blood-brain barrier models. This knowledge is valuable for planning the optimal r…
View article: MOESM4 of The endo-lysosomal system of bEnd.3 and hCMEC/D3 brain endothelial cells
MOESM4 of The endo-lysosomal system of bEnd.3 and hCMEC/D3 brain endothelial cells Open
Additional file 4. Subcellular zones. Based on the lateral distance from the nucleus, subcellular zones were defined inside the cells. The juxtanuclear zone covers the area of nuclei and 1 µm around. The peripheral zone of the cells was de…
View article: MOESM2 of The endo-lysosomal system of bEnd.3 and hCMEC/D3 brain endothelial cells
MOESM2 of The endo-lysosomal system of bEnd.3 and hCMEC/D3 brain endothelial cells Open
Additional file 2. Western blots showing the presence of different endosomal markers and β-actin in all the investigated groups.
View article: MOESM1 of The endo-lysosomal system of bEnd.3 and hCMEC/D3 brain endothelial cells
MOESM1 of The endo-lysosomal system of bEnd.3 and hCMEC/D3 brain endothelial cells Open
Additional file 1. List of antibodies applied for immunofluorescence and Western blot.
View article: MOESM3 of The endo-lysosomal system of bEnd.3 and hCMEC/D3 brain endothelial cells
MOESM3 of The endo-lysosomal system of bEnd.3 and hCMEC/D3 brain endothelial cells Open
Additional file 3. Representative confocal microscopy images of LysoSensor Green DND-189 (green)-loaded brain endothelial cells with or without bafilomycin. Nucleus is marked with blue. Magnification is 60×. Scale bar: 10 µm.
View article: Comparison of a Rat Primary Cell-Based Blood-Brain Barrier Model With Epithelial and Brain Endothelial Cell Lines: Gene Expression and Drug Transport
Comparison of a Rat Primary Cell-Based Blood-Brain Barrier Model With Epithelial and Brain Endothelial Cell Lines: Gene Expression and Drug Transport Open
Cell culture-based blood-brain barrier (BBB) models are useful tools for screening of CNS drug candidates. Cell sources for BBB models include primary brain endothelial cells or immortalized brain endothelial cell lines. Despite their well…
View article: Analysis of the trafficking system in blood-brain barrier models by high content screening microscopy
Analysis of the trafficking system in blood-brain barrier models by high content screening microscopy Open
The blood-brain barrier (BBB) and drug delivery: In our modern societies, the prevalence of nervous system disorders is increasing in relation to the aging population. To overcome this problem, several interesting pharmacons and biomolecul…
View article: Improved Method for the Establishment of an <em>In Vitro</em> Blood-Brain Barrier Model Based on Porcine Brain Endothelial Cells
Improved Method for the Establishment of an <em>In Vitro</em> Blood-Brain Barrier Model Based on Porcine Brain Endothelial Cells Open
The aim of this protocol presents an optimized procedure for the purification and cultivation of pBECs and to establish in vitro blood-brain barrier (BBB) models based on pBECs in mono-culture (MC), MC with astrocyte-conditioned medium (AC…
View article: Restraint Stress-Induced Morphological Changes at the Blood-Brain Barrier in Adult Rats
Restraint Stress-Induced Morphological Changes at the Blood-Brain Barrier in Adult Rats Open
Stress is well-known to contribute to the development of both neurological and psychiatric diseases. While the role of the blood-brain barrier is increasingly recognized in the development of neurodegenerative disorders, such as Alzheimer'…
View article: Supplementary Material for: Analysis of Pediatric Pancreatitis (APPLE Trial): Pre-Study Protocol of a Multinational Prospective Clinical Trial
Supplementary Material for: Analysis of Pediatric Pancreatitis (APPLE Trial): Pre-Study Protocol of a Multinational Prospective Clinical Trial Open
Background: Single-centered studies show increased number of acute pancreatitis (AP) in children. Here, the Pediatric Section of the Hungarian Pancreatic Study Group introduces an international observational clinical trial (APPLE) to colle…
View article: Supplementary Material for: Analysis of Pediatric Pancreatitis (APPLE Trial): Pre-Study Protocol of a Multinational Prospective Clinical Trial
Supplementary Material for: Analysis of Pediatric Pancreatitis (APPLE Trial): Pre-Study Protocol of a Multinational Prospective Clinical Trial Open
Background: Single-centered studies show increased number of acute pancreatitis (AP) in children. Here, the Pediatric Section of the Hungarian Pancreatic Study Group introduces an international observational clinical trial (APPLE) to colle…