Noemi Veraldi
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The plasma proteome differentiates the multisystem inflammatory syndrome in children (MIS-C) from children with SARS-CoV-2 negative sepsis Open
Background The Multi-System Inflammatory Syndrome in Children (MIS-C) can develop several weeks after SARS-CoV-2 infection and requires a distinct treatment protocol. Distinguishing MIS-C from SARS-CoV-2 negative sepsis (SCNS) patients is …
RB818 and RB819 antibodies recognize a low-molecular weight highly sulfated marine exopolysaccharide derivative by ELISA Open
The recombinant antibodies RB818 and RB819 detect by ELISA a low-molecular weight highly sulfated marine exopolysaccharide derivative.
Endothelial glycocalyx degradation in multisystem inflammatory syndrome in children related to COVID-19 Open
Multisystem inflammatory syndrome in children (MIS-C) represents a rare but severe complication of severe acute respiratory syndrome coronavirus 2 infection affecting children that can lead to myocardial injury and shock. Vascular endothel…
Characterization of a spontaneous cell line from primary mouse fibroblasts as a model to study Sanfilippo syndrome Open
To evaluate a new approach to Mucopolysaccharidosis type IIIA (MPS-IIIA), work was initiated on primary fibroblasts from a well-known mouse model in which sulfamidase deficiency correlates with the accumulation of heparan sulfate - the hal…
The Challenge of Modulating Heparan Sulfate Turnover by Multitarget Heparin Derivatives Open
This review comes as a part of the special issue “Emerging frontiers in GAGs and mimetics”. Our interest is in the manipulation of heparan sulfate (HS) turnover by employing HS mimetics/heparin derivatives that exert pleiotropic effects an…
View article: Structural Features of Heparan Sulfate from Multiple Osteochondromas and Chondrosarcomas
Structural Features of Heparan Sulfate from Multiple Osteochondromas and Chondrosarcomas Open
Multiple osteochondromas (MO) is a hereditary disorder associated with benign cartilaginous tumors, known to be characterized by absence or highly reduced amount of heparan sulfate (HS) in the extracellular matrix of growth plate cartilage…
Synthesized Heparan Sulfate Competitors Attenuate Pseudomonas aeruginosa Lung Infection Open
Several chronic respiratory diseases are characterized by recurrent and/or persistent infections, chronic inflammatory responses and tissue remodeling, including increased levels of glycosaminoglycans which are known structural components …