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View article: Assessing the diagnostic potential of SATB2 and β-catenin as biomarkers and therapeutic targets in pancreatic ductal adenocarcinoma
Assessing the diagnostic potential of SATB2 and β-catenin as biomarkers and therapeutic targets in pancreatic ductal adenocarcinoma Open
View article: Synergistic immunomodulatory effect of synbiotics pre- and postoperative resection of pancreatic ductal adenocarcinoma: a randomized controlled study
Synergistic immunomodulatory effect of synbiotics pre- and postoperative resection of pancreatic ductal adenocarcinoma: a randomized controlled study Open
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a highly immunosuppressive microenvironment. This single-blind, randomized study aimed to evaluate the synergistic immunomodulatory effects of synbiotics (probiotics and …
View article: The association of p21, inhibin, and Tob-1 expression with the clinicopathological characteristics of benign and malignant colorectal lesions
The association of p21, inhibin, and Tob-1 expression with the clinicopathological characteristics of benign and malignant colorectal lesions Open
Background Worldwide, colorectal cancer (CRC) is the third most common cancer and the second most common cause of cancer-related deaths. p21, inhibin, and Tob-1 are tumor suppressors that play a role in the development and progression of s…
View article: Nanoconjugated long non-coding RNA MEG3 as a new therapeutic approach for Hepatocellular carcinoma
Nanoconjugated long non-coding RNA MEG3 as a new therapeutic approach for Hepatocellular carcinoma Open
View article: The impact of increased body mass index on the outcomes after valve replacement
The impact of increased body mass index on the outcomes after valve replacement Open
Background: The association between obesity and the outcomes of surgery is controversial. This study aimed to assess the effect of body mass index (BMI) on early and late morbidity and mortality after valve replacement surgery.
Methods: T…
View article: Hepatic and gastrointestinal complications after adult cardiac surgery
Hepatic and gastrointestinal complications after adult cardiac surgery Open
Background: Gastrointestinal tract (GIT) complications are associated with increased morbidity and mortality after cardiac surgery. Therefore, The goal of this research was to estimate the frequency of GIT and hepatic complications after c…
View article: Assessment of survivin and p27 expression as potential prognostic markers in urothelial cell carcinoma of urinary bladder in Egyptian patients
Assessment of survivin and p27 expression as potential prognostic markers in urothelial cell carcinoma of urinary bladder in Egyptian patients Open
View article: Prognostic Significance of p27 and Survivin in H. pylori Gastritis and Gastric Cancer
Prognostic Significance of p27 and Survivin in H. pylori Gastritis and Gastric Cancer Open
Inverse relation between p27 and survivin in H. pylori gastritis, H. pylori gastritis with IM and IGCs lesions, suggesting that both proteins could be used as potential prognostic and/or diagnostic biomarkers in H. pylori and IM associated…
View article: MicroRNA-26a systemic administration attenuates tumor formation in hepatocellular carcinoma mouse model.
MicroRNA-26a systemic administration attenuates tumor formation in hepatocellular carcinoma mouse model. Open
MicroRNA (miRNA)-26a is one of the tumor suppressor genes that has been down regulated during the development of hepatocellular carcinoma (HCC). This work was conducted to evaluate the possible preventive effect of exogenous miRNA-26a admi…
View article: IL-4, IL-17 and CD163 Immunoexpression and IL-6 Gene Polymorphism in Chronic Hepatitis C Patients and Associated Hepatocellular Carcinoma
IL-4, IL-17 and CD163 Immunoexpression and IL-6 Gene Polymorphism in Chronic Hepatitis C Patients and Associated Hepatocellular Carcinoma Open
IL-4, IL-17 and CD163 were associated with HCV severity. Their expression in HCC suggests their important role in HCC development. Blocking of these proteins may be a good target to control inflammation in HCV and can hinder progression to…
View article: Predictive Value of CDX2 and SOX2 in Chronic Gastritis and Intestinal-type Gastric Cancer
Predictive Value of CDX2 and SOX2 in Chronic Gastritis and Intestinal-type Gastric Cancer Open
BACKGROUND: Worldwide gastric cancer (GC) ranks sixth in incidence and second in mortality among all malignancies. CDX2 has an essential role in the development and maintenance of intestinal differentiation in the gut and ectopic sites suc…
View article: Differential Expression of HER2 and SKP2 in Benign and Malignant Colorectal Lesions
Differential Expression of HER2 and SKP2 in Benign and Malignant Colorectal Lesions Open
A small percent of CRCs exhibited HER2 gene amplification, which would be potential candidates for anti HER2 therapy whereas IHC could be a primary screening test for patient selection. A potential carcinogenic role of SKP2 was suggested b…
View article: Assessment of metallothionein expression in Biomphalaria alexandrina snails and Oreochromis niloticus Fish as a biomarker for water pollution with heavy metals.
Assessment of metallothionein expression in Biomphalaria alexandrina snails and Oreochromis niloticus Fish as a biomarker for water pollution with heavy metals. Open
Metallothioneins (MTs) are small cysteine-rich proteins that play important roles in metal homeostasis and protection against heavy metals; therefore, they were used as biomarkers to evaluate metals pollution in the aquatic ecosystem. The …
View article: Trends in liver biopsy in Egyptian patients over three decades
Trends in liver biopsy in Egyptian patients over three decades Open
View article: Comparative Expression of RAGE and SOX2 in Benign and Malignant Prostatic Lesions
Comparative Expression of RAGE and SOX2 in Benign and Malignant Prostatic Lesions Open
Background: Prostate cancer (PCa) is a common health problem in elderly. RAGE (Receptor for advanced glycation end products) is overexpressed in multiple human cancers. SOX2 (Sex-determining region Y box 2) also functions as an oncoprotein…
View article: Overview of MDM2 and B-RAF Expression in Gastric Lesions
Overview of MDM2 and B-RAF Expression in Gastric Lesions Open
BACKGROUND: Globally, gastric cancer (GC) it is the fourth most common cancer and the third cause of cancer-related deaths. Overexpression of MDM2 and B-RAF appeared to be increased in malignancy and associated with poor prognosis in sever…
View article: Liver Protective Effects of Renin-Angiotensin System Inhibition Have No Survival Benefits in Hepatocellular Carcinoma Induced By Repetitive Administration of Diethylnitrosamine in Mice
Liver Protective Effects of Renin-Angiotensin System Inhibition Have No Survival Benefits in Hepatocellular Carcinoma Induced By Repetitive Administration of Diethylnitrosamine in Mice Open
BACKGROUND: Preclinical studies have demonstrated that renin-angiotensin system (RAS) signalling has strong tumour-promoting effects and RAS inhibition was associated with improvement in the overall survival in some cancer types including …
View article: Perindopril, fosinopril and losartan inhibited the progression of diethylnitrosamine-induced hepatocellular carcinoma in mice via the inactivation of nuclear transcription factor kappa-B
Perindopril, fosinopril and losartan inhibited the progression of diethylnitrosamine-induced hepatocellular carcinoma in mice via the inactivation of nuclear transcription factor kappa-B Open
Hepatocellular carcinoma (HCC) is a major global health problem. Therapeutic interventions of HCC are still limited because of its complicated molecular pathogenesis. Many reports showed that renin-angiotensin system (RAS) contributes to t…
View article: Impact of Cyclin D1 and Heterogeneous NuclearRibonucleoprotein-K (HnRNP-K) on Urinary BladderCarcinogenesis
Impact of Cyclin D1 and Heterogeneous NuclearRibonucleoprotein-K (HnRNP-K) on Urinary BladderCarcinogenesis Open
Objective: This study aimed to investigate the expression of cyclin D1 and hnRNP-K in relation to the pathological findings in bladder cancer including the type, grade, muscle invasion and bilharzial association. Methods: We studied the im…
View article: Immunohistochemical and Biochemical Expression Patterns of TTF-1, RAGE, GLUT-1 and SOX2 in HCV-Associated Hepatocellular Carcinomas
Immunohistochemical and Biochemical Expression Patterns of TTF-1, RAGE, GLUT-1 and SOX2 in HCV-Associated Hepatocellular Carcinomas Open
Objective: To investigate the expression of TTF-1, RAGE, GLUT1 and SOX2 in HCV-associated HCCs and in surrounding non-tumorous liver tissue. Material and Methods: Tissue material from partial hepatectomy cases for HCC along with correspond…
View article: Comparative study of liver biopsy results in egypt over three decades
Comparative study of liver biopsy results in egypt over three decades Open
Indications for liver biopsy technique were changed a lot over the recent few years.This was associated with dramatic revolution in viral diagnosis, viral vaccination and anti-viral therapy.This current work deals with a retrospective stud…
View article: Urinary Bladder Schistosomiasis
Urinary Bladder Schistosomiasis Open
View article: Expression of Epidermal Growth Factor Receptor and Transforming Growth Factor Alpha in Cancer Bladder: Schistosomal and Non-Schistosomal
Expression of Epidermal Growth Factor Receptor and Transforming Growth Factor Alpha in Cancer Bladder: Schistosomal and Non-Schistosomal Open
EGFR and TGFα could be used as prognostic predictors in early stage and grade of bladder cancer cases, especially those with schistosomal association. In addition they can help in selecting patients who can get benefit from anti-EGFR molec…