Explanipedia

210 Anti-IL-15 treatment results in greater repigmentation in vitiligo than placebo in participants who receive phototherapy and reduces circulating terminally differentiated cytotoxic CD8 memory cells Open

Dawn E. Smilek, Laura G. Cooney, Marc Lytle, Karen Boyle, Matthew L. Sherman , et al. · 2025

Latent EBV enhances the efficacy of teplizumab in Type 1 diabetes 3614 Open

Alberto Álvarez Delgado, Paula Preston‐Hurlburt, Lauren E. Higdon, Noha Lim, S. Alice Long , et al. · 2025

Description Teplizumab is approved for delay of diagnosis of type 1 diabetes and modulates new onset disease. Compared to EBV seronegative patients, those who were EBV seropositive prior to treatment had a more robust response to drug in t…

Systematic data capture reduces the need for source data verification: exploratory analysis from a phase 2 multicenter randomized controlled platform trial Open

Ali B. Abbasi, Karl W. Thomas, Fady Yousef, Sheetal Gandotra, Andrea Discacciati , et al. · 2025

Background The COVID-19 pandemic gave rise to clinical trials focused on systematic, accurate primary data capture, and reduced reliance on source data verification (SDV). Here, we report on a natural experiment that allowed us to assess t…

Latent EBV enhances the efficacy of anti-CD3 mAb in Type 1 diabetes Open

Ana Lledó-Delgado, Paula Preston‐Hurlburt, Lauren E. Higdon, Alex Hu, Eddie A. James , et al. · 2025

Teplizumab is approved for delaying the diagnosis of type 1 diabetes by modulating progression of disease. Compared to EBV-seronegative patients, those who are EBV-seropositive prior to treatment have a more robust response to teplizumab i…

Peanut-specific IgG subclasses as biomarkers of peanut allergy in LEAP study participants Open

Carolyn Baloh, Noha Lim, Michelle F. Huffaker, Pooja Patel, Jody Tversky , et al. · 2024

Impact on in-depth immunophenotyping of delay to peripheral blood processing Open

Lauren E. Higdon, Sheila Scheiding, Anna Kus, Noha Lim, S. Alice Long , et al. · 2024

Peripheral blood mononuclear cell (PBMC) immunophenotyping is crucial in tracking activation, disease state, and response to therapy in human subjects. Many studies require the shipping of blood from clinical sites to a laboratory for proc…

Immunosuppression withdrawal in living-donor renal transplant recipients following induction with antithymocyte globulin and rituximab: Results of a prospective clinical trial Open

James F. Markmann, Bryna E. Burrell, Jonathan S. Bromberg, Choli Hartono, Dixon B. Kaufman , et al. · 2024

230 Immunosuppression causes dynamic changes in expression QTLs in psoriatic skin Open

Laura A. Cooney, Qian Xiao, Jason A. Mears, Anusha Louly Nathan, K. Ishigaki , et al. · 2023

Immunosuppression causes dynamic changes in expression QTLs in psoriatic skin Open

Qian Xiao, Joseph Mears, Aparna Nathan, Kazuyoshi Ishigaki, Yuriy Baglaenko , et al. · 2023

Latent EBV impairs immune cell signaling and enhances the efficacy of anti-CD3 mAb in Type 1 Diabetes Open

A. Lledó, Paula Preston‐Hurlburt, Noha Lim, Tomokazu S. Sumida, S. Alice Long , et al. · 2023

Summary Teplizumab has been approved for the delay of the onset of type 1 diabetes and may modulate new onset disease. We found that patients who were EBV positive at baseline had a more robust response to drug in two clinical trials and t…

Immunosuppression causes dynamic changes in expression QTLs in psoriatic skin Open

Qian Xiao, Joseph Mears, Aparna Nathan, Kazuyoshi Ishigaki, Yuriy Baglaenko , et al. · 2022

Background Psoriasis is a chronic, systemic inflammatory condition, primarily affecting skin and joints. It is an immune-mediated disease driven by IL-17-producing T cells in the skin. However, epidermal cells such as keratinocytes are now…

Stabilization of leukocytes from cerebrospinal fluid for central immunophenotypic evaluation in multicenter clinical trials Open

Ina Mexhitaj, Noha Lim, José Ignacio Fernández-Velasco, Tobias Zrzavy, Kristina M. Harris , et al. · 2022

Analysis of cerebrospinal fluid (CSF) represents a valuable window into the pathogenesis of neuroinflammatory diseases, such as multiple sclerosis (MS). However, analysis of the cellular fraction of CSF is often neglected because CSF cells…

Association of baseline soluble immune checkpoints with the risk of relapse in PR3-ANCA vasculitis following induction of remission Open

Gabriele Gamerith, Finn Mildner, Peter A. Merkel, Kristina M. Harris, Laura G. Cooney , et al. · 2022

Peanut-Specific IgG4 and IgA in Saliva Are Modulated by Peanut Oral Immunotherapy Open

Johanna M. Smeekens, Carolyn Baloh, Noha Lim, David Larson, Tielin Qin , et al. · 2022

Effect of Costimulatory Blockade With Abatacept After Ustekinumab Withdrawal in Patients With Moderate to Severe Plaque Psoriasis Open

Kristina M. Harris, Dawn E. Smilek, M. Byron, Noha Lim, William T. Barry , et al. · 2021

The purpose of this study is to determine if the use of ustekinumab, followed by abatacept, will prevent relapse in people with moderate to severe plaque psoriasis.

Imatinib therapy for patients with recent-onset type 1 diabetes: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial Open

Stephen E. Gitelman, Brian N. Bundy, Ele Ferrannini, Noha Lim, Lori Blanchfield , et al. · 2021

Juvenile Research Diabetes Foundation.

Correction: Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution Open

Cecilia M. Lindgren, Iris M. Heid, Joshua C. Randall, Claudia Lamina, Valgerður Steinthórsdóttir , et al. · 2021

To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist–hip ratio (WHR). We s…

Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals Open

Emily K. Sims, Brian N. Bundy, Kenneth Stier, Elisavet Serti, Noha Lim , et al. · 2021

Teplizumab treatment of nondiabetic relatives at high risk for T1D induces partially exhausted CD8 + T cells and improves beta cell function.

Imatinib Therapy for Patients with Recent-Onset Type 1 Diabetes: A Randomised Blinded Phase 2 Trial Open

Stephen E. Gitelman, Brian N. Bundy, Ele Ferrannini, Noha Lim, J. Lori Blanchfield , et al. · 2021

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation Open

Cristen J. Willer, Elizabeth K. Speliotes, Ruth J. F. Loos, Shengxu Li, Cecilia M. Lindgren , et al. · 2020

Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and …

Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients Open

Mark Rigby, Kristina M. Harris, Ashley Pinckney, Linda A. DiMeglio, Marc Rendell , et al. · 2020

BACKGROUND. Type 1 diabetes (T1D) results from destruction of pancreatic β cells by autoreactive effector T cells. We hypothesized that the immunomodulatory drug alefacept would result in targeted quantitative and qualitative changes in ef…

Fc receptor-like 5 and anti-CD20 treatment response in granulomatosis with polyangiitis and microscopic polyangiitis Open

Kasia Owczarczyk, Matthew D. Cascino, Cécile Holweg, Gaik W. Tew, Ward Ortmann , et al. · 2020

BACKGROUNDBaseline expression of FCRL5, a marker of naive and memory B cells, was shown to predict response to rituximab (RTX) in rheumatoid arthritis. This study investigated baseline expression of FCRL5 as a potential biomarker of clinic…

Development of peanut allergy is associated with coding SNPs in the C-terminus of the IL-33 receptor that impact signaling and TH2 effector function Open

Karen Cerosaletti, Janice Chen, Eleanor H. Johnson, Nahir Garabatos, Justine Calise , et al. · 2020

Extensive intrathecal T cell renewal following hematopoietic transplantation for multiple sclerosis Open

Kristina M. Harris, Noha Lim, Paul Lindau, Harlan Robins, Linda M. Griffith , et al. · 2019

A recent study of autologous hematopoietic stem cell transplantation (AHSCT) for active relapsing-remitting multiple sclerosis (RRMS) showed efficacy in preventing disease worsening. However, the immunologic basis for efficacy remains poor…

Association of Staphylococcus aureus colonization with food allergy occurs independently of eczema severity Open

Olympia Tsilochristou, George Du Toit, Peter H. Sayre, Graham Roberts, Kaitie Lawson , et al. · 2019

Challenges and Opportunities for Biomarkers of Clinical Response to AHSCT in Autoimmunity Open

Kristina M. Harris, Tingting Lü, Noha Lim, Laurence A. Turka · 2018

Autoimmunity represents a broad category of diseases that involve a variety of organ targets and distinct autoantigens. For patients with autoimmune diseases who fail to respond to approved disease-modifying treatments, autologous hematopo…

Glycan microarray reveal induced IgGs repertoire shift against a dietary carbohydrate in response to rabbit anti-human thymocyte therapy Open

Ron Amon, Shani Leviatan Ben‐Arye, Limor Engler, Hai Yu, Noha Lim , et al. · 2017

Humans have circulating antibodies against diverse glycans containing N-glycolylneuraminic acid (Neu5Gc) due to function-loss mutation of the CMAH gene. This xenogenic non-human carbohydrate is abundant in red meat, xenograft…

Reply to Christakoudi and Hernandez-Fuentes: We agree—Let’s move on Open

Adam L. Asare, Sai Kanaparthi, Noha Lim, Kenneth A. Newell, Laurence A. Turka · 2017

To the Editor In regard to the Letter to the Editor by Christakoudi and Hernandez-Fuentes 1Christakoudi S Hernandez-Fuentes MP Lack of adjustment for confounding could lead to misleading conclusions.Am J Transplant. 2017; 17 (https://doi.o…

Allergen specificity of early peanut consumption and effect on development of allergic disease in the Learning Early About Peanut Allergy study cohort Open

George Du Toit, Peter H. Sayre, Graham Roberts, Kaitie Lawson, Michelle L. Sever , et al. · 2017

Remodeling T cell compartments during anti-CD3 immunotherapy of type 1 diabetes Open

S. Alice Long, Jerill Thorpe, Kevan C. Herold, Mario R. Ehlers, Srinath Sanda , et al. · 2017

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