Noha M. Mesbah
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View article: Neuroprotective Effects of Cilomilast and Chlorogenic Acid Against Scopolamine-Induced Memory Deficits via Modulation of the cAMP/PKA–CREB–BDNF Pathway
Neuroprotective Effects of Cilomilast and Chlorogenic Acid Against Scopolamine-Induced Memory Deficits via Modulation of the cAMP/PKA–CREB–BDNF Pathway Open
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline, neuroinflammation and neuronal damage. This study aimed to investigate the neuroprotective effects of cilomilast (CILO), a phosphodiesterase-4 (PD…
View article: Targeting Glutamine Metabolismm: A Novel Approach to Combat Hepatic Fibrosis
Targeting Glutamine Metabolismm: A Novel Approach to Combat Hepatic Fibrosis Open
View article: Gastric Ulcer: An Overview of Pathophysiology, Diagnosis, and Management
Gastric Ulcer: An Overview of Pathophysiology, Diagnosis, and Management Open
View article: Occult Hepatitis B and C among injection drug users (IDUs): An Overlooked Obstacle in Global Health Efforts.
Occult Hepatitis B and C among injection drug users (IDUs): An Overlooked Obstacle in Global Health Efforts. Open
View article: Circulating Cell Free DNA (ccfDNA): Is It The Future of Breast Cancer Diagnosis?
Circulating Cell Free DNA (ccfDNA): Is It The Future of Breast Cancer Diagnosis? Open
View article: The relationship between gallstone disease and the genetic variants of the sterol transporter adenosine triphosphate–binding cassette G8 and G5 in Egyptians
The relationship between gallstone disease and the genetic variants of the sterol transporter adenosine triphosphate–binding cassette G8 and G5 in Egyptians Open
Background Gallstones are abnormal lumps in the gallbladder or biliary tract due impaired cholesterol, bilirubin, or bile salt metabolism. The Adenosine triphosphate binding cassette transporter genes G5 and G8 (ABCG5, ABCG8) are two half …
View article: The hidden epidemic of occult hepatitis B and C among injection drug users (IDUs): A call for action.
The hidden epidemic of occult hepatitis B and C among injection drug users (IDUs): A call for action. Open
Hidden infections such as OBI and OCI remain an overlooked public health issue in Egypt's IDU population. These findings highlight the need for targeted strategies to address these reservoirs of infection and could inform similar approache…
View article: Genetic and Epigenetic Insights into Osteoarthritis Pathogenesis; Spotlighting STAT3 and miR-452-3p as Illuminating Examples
Genetic and Epigenetic Insights into Osteoarthritis Pathogenesis; Spotlighting STAT3 and miR-452-3p as Illuminating Examples Open
Osteoarthritis (OA) is a chronic degenerative joint disease, characterized by progressive degradation and loss of articular cartilage, subchondral bone sclerosis, inflammation, and osteophyte formation. Edema, chronic pain, and limited joi…
View article: Coronary Artery Spasm—Risk Factors and Pathophysiological Mechanisms
Coronary Artery Spasm—Risk Factors and Pathophysiological Mechanisms Open
View article: MicroRNAs in Breast Cancer: Insights into Diagnosis, Mechanisms, and Targeted Therapy
MicroRNAs in Breast Cancer: Insights into Diagnosis, Mechanisms, and Targeted Therapy Open
View article: Pathophysiological Mechanisms of Diabetic Nephropathy: Role of S1R/Nrf2 Antioxidant Axis
Pathophysiological Mechanisms of Diabetic Nephropathy: Role of S1R/Nrf2 Antioxidant Axis Open
View article: Comprehensive Insights into Psoriasis: Disease Types, Underlying Mechanisms, and Effective Treatments
Comprehensive Insights into Psoriasis: Disease Types, Underlying Mechanisms, and Effective Treatments Open
View article: Tumor-associated macrophages and cancer metastasis
Tumor-associated macrophages and cancer metastasis Open
Tumour-associated macrophages (TAMs) play an important role in cancer metastasis by creating a favourable microenvironment for cancer cell survival, growth, and spread. These pathways ultimately affect the immune system and the development…
View article: The polyextremophile <i>Natranaerobius thermophilus</i> adopts a dual adaptive strategy to long-term salinity stress, simultaneously accumulating compatible solutes and K <sup>+</sup>
The polyextremophile <i>Natranaerobius thermophilus</i> adopts a dual adaptive strategy to long-term salinity stress, simultaneously accumulating compatible solutes and K <sup>+</sup> Open
The bacterium Natranaerobius thermophilus is an extremely halophilic alkalithermophile that can thrive under conditions of high salinity (3.3–3.9 M Na + ), alkaline pH (9.5), and elevated temperature (53°C). To understand the molecular mec…
View article: MiRNAs as Promising Therapeutic Targets for Breast Cancer
MiRNAs as Promising Therapeutic Targets for Breast Cancer Open
Breast cancer (BC) is the most common cause of cancer-related death and is the malignancy most frequently diagnosed in females worldwide. BC incidence is predicted to continue increasing worldwide. Without interventions, annual new cases w…
View article: The antitumour efficacyof hesperidin vs. cisplatin againstnon‑small lung cancer cellsA549 and H460 via targetingthe miR‑34a/PD-L1/NF-κB signallingpathway
The antitumour efficacyof hesperidin vs. cisplatin againstnon‑small lung cancer cellsA549 and H460 via targetingthe miR‑34a/PD-L1/NF-κB signallingpathway Open
Our study demonstrated that hesperidin extract could significantly inhibit non-small lung cancer cell growth by induction of the apoptosis signalling pathway. Therefore, hesperidin might open novel strategies for effective and safe cancer …
View article: Afobazole Alleviates Streptozotocin-Induced Diabetic Nephropathy in Rats Via Hypoglycemic, Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties: Role of the S1r/Nrf2 Antioxidant Axis
Afobazole Alleviates Streptozotocin-Induced Diabetic Nephropathy in Rats Via Hypoglycemic, Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties: Role of the S1r/Nrf2 Antioxidant Axis Open
View article: CD-36 Variants and Circulating MiRNAs as Prognostic Biomarkers and Potential Therapeutic Targets in Breast Cancer Patients
CD-36 Variants and Circulating MiRNAs as Prognostic Biomarkers and Potential Therapeutic Targets in Breast Cancer Patients Open
View article: The Safety and Efficacy of Combining Saxagliptin and Pioglitazone Therapy in Streptozocin-Induced Diabetic Rats
The Safety and Efficacy of Combining Saxagliptin and Pioglitazone Therapy in Streptozocin-Induced Diabetic Rats Open
Background: Type 2 diabetes mellitus (T2DM) is a chronic progressive disease due to insulin resistance. Oxidative stress complicates the etiology of T2DM. Saxagliptin is a selective dipeptidyl peptidase-4 (DPP-4) inhibitor, while Pioglitaz…
View article: Relation of STAT3 rs1053005 Variation and miR-452-3p with Osteoarthritis Susceptibility and Severity and the Clinical Response to High-Molecular-Weight Hyaluronic Acid Injection in Osteoarthritis Patients
Relation of STAT3 rs1053005 Variation and miR-452-3p with Osteoarthritis Susceptibility and Severity and the Clinical Response to High-Molecular-Weight Hyaluronic Acid Injection in Osteoarthritis Patients Open
Polymorphisms in the 3′ untranslated region of STAT3 mRNA can derange STAT3 gene expression via modifying the microRNA-binding site. This study aimed to examine the impact of STAT3 rs1053005 variation and miR-452-3p expression on osteoarth…
View article: Correction: Quantitative evaluation of endogenous reference genes for ddPCR under salt stress using a moderate halophile
Correction: Quantitative evaluation of endogenous reference genes for ddPCR under salt stress using a moderate halophile Open
View article: Serum Transforming Growth Factor β1 and Its Genetic Variants Are Associated with Increased Macrophage Inflammatory Protein 1β and Susceptibility to Idiopathic Carpal Tunnel Syndrome
Serum Transforming Growth Factor β1 and Its Genetic Variants Are Associated with Increased Macrophage Inflammatory Protein 1β and Susceptibility to Idiopathic Carpal Tunnel Syndrome Open
Carpal tunnel syndrome (CTS) is a common entrapment neuropathy in which one of the body’s peripheral nerves becomes pinched or crushed. Transforming growth factor beta 1 (TGF-β1) plays an important role in the pathogenesis of CTS. An assoc…
View article: The relation of VEGFA, VEGFR2, VEGI, and HIF1A genetic variants and their serum protein levels with breast cancer in Egyptian patients
The relation of VEGFA, VEGFR2, VEGI, and HIF1A genetic variants and their serum protein levels with breast cancer in Egyptian patients Open
Breast cancer is the most common type of cancer in Egyptian females. Polymorphisms in the angiogenesis pathway have been implicated previously in cancer risk and prognosis. The aim of the current study was to determine whether certain poly…
View article: Pro-Neurotensin as a Potential Novel Diagnostic Biomarker for Detection of Nonalcoholic Fatty Liver Disease
Pro-Neurotensin as a Potential Novel Diagnostic Biomarker for Detection of Nonalcoholic Fatty Liver Disease Open
BACKGROUND AND AIMS: Currently, liver biopsy is the gold standard method for diagnosis of non-alcoholic fatty liver severity. It is critical to develop non-invasive diagnostic method to diagnose nonalcoholic fatty liver rather than invasiv…
View article: Selenium nanoparticles overcomes sorafenib resistance in thioacetamide induced hepatocellular carcinoma in rats by modulation of mTOR, NF-κB pathways and LncRNA-AF085935/GPC3 axis
Selenium nanoparticles overcomes sorafenib resistance in thioacetamide induced hepatocellular carcinoma in rats by modulation of mTOR, NF-κB pathways and LncRNA-AF085935/GPC3 axis Open
SOR/SeNps are a promising combination for tumor suppression and overcoming sorafenib resistance in HCC by modulating apoptosis, AKT/mTOR and NF-κB pathways, as well as CD34 and lncRNA-AF085935/GPC3 axis.
View article: Effect of Autologous Bone Marrow Derived Mesenchymal Stem Cells in Treatment of Rheumatoid Arthritis
Effect of Autologous Bone Marrow Derived Mesenchymal Stem Cells in Treatment of Rheumatoid Arthritis Open
Introduction: Chronic inflammation causes articular bone and cartilage degeneration in people with rheumatoid arthritis (RA). Despite recent advancements in the management of RA, adverse side effects and ineffective treatments remain a pro…
View article: Prevalence of Occult Hepatitis C Virus Infection in Egyptian Patients with Lymphoma: A New Vision
Prevalence of Occult Hepatitis C Virus Infection in Egyptian Patients with Lymphoma: A New Vision Open
Occult hepatitis C virus infection (OCI) is the absence of HCV RNA in serum and the presence of actively replicating HCV RNA in hepatocytes and peripheral blood mononuclear cells (PBMCs), as evidenced by the presence of antigenomic negativ…
View article: Cyanidin-3-Glucoside Modulates hsa_circ_0001345/miRNA106b/ATG16L1 Axis Expression as a Potential Protective Mechanism against Hepatocellular Carcinoma
Cyanidin-3-Glucoside Modulates hsa_circ_0001345/miRNA106b/ATG16L1 Axis Expression as a Potential Protective Mechanism against Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC) is the most common form of malignancy in the liver. Autophagy was found to have a significant effect in controlling HCC. Anthocyanins, which are naturally occurring pigments in a variety of fruits and vegetab…
View article: Industrial Biotechnology Based on Enzymes From Extreme Environments
Industrial Biotechnology Based on Enzymes From Extreme Environments Open
Biocatalysis is crucial for a green, sustainable, biobased economy, and this has driven major advances in biotechnology and biocatalysis over the past 2 decades. There are numerous benefits to biocatalysis, including increased selectivity …
View article: Hepatocellular carcinoma pathogenesis: Epigenetics and relationship with cancer hallmarks
Hepatocellular carcinoma pathogenesis: Epigenetics and relationship with cancer hallmarks Open
On the global scale, primary liver cancer (PLC) is the second leading cause of death due to cancer in men, and the third most prevalent cause of death in both sexes.Hepatocellular carcinoma (HCC) accounts for almost 75% of the total cases …