Nolan Holley
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View article: Safety and outcomes of venetoclax initiation in patients with AML and hyperleukocytosis
Safety and outcomes of venetoclax initiation in patients with AML and hyperleukocytosis Open
Introduction: Venetoclax in combination with hypomethylating agents has improved outcomes in acute myeloid leukemia. However, the FDA black box warning for tumor lysis syndrome, especially in patients with elevated white blood cell counts …
Luspatercept for the treatment of myelodysplastic syndrome: A retrospective cohort study utilizing trinetx Open
Introduction Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell disorders defined by ineffective hematopoiesis, peripheral cytopenias, and dysplasia across one or more myeloid lineages. The underlying pathophysiology involv…
Histoplasmosis-Associated Hemophagocytic Lymphohistiocytosis in the Setting of Granulomatosis With Polyangiitis Open
Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and potentially life-threatening syndrome of aberrant immune hyperactivation characterized by excess cytokine release due to abnormal cytotoxic T-cell and macrophage activation. Sec…
A Possible Association Between Rituximab and the Subsequent Development of Guillain–Barré Syndrome: A Case Report Open
Background and Clinical Significance: Hematologic malignancies, including diffuse large B-cell lymphoma (DLBCL), have been associated with the development of Guillain–Barré syndrome (GBS). Specifically, treatment with the immunomodulator r…
Successful Treatment of Primary Central Nervous System T-Cell Lymphoma With Induction Chemotherapy Followed by Consolidation With High-Dose Chemotherapy and Autologous Stem Cell Rescue Open
Primary central nervous system T-cell lymphoma (PCNSTL) is an exceptionally rare subtype of non-Hodgkin lymphoma, comprising only 2% of primary CNS lymphoma cases. Due to its rarity, PCNSTL is often misdiagnosed, lacks standardized treatme…
View article: New onset of hypertension associated with immune checkpoint inhibitor therapy in cancer patients
New onset of hypertension associated with immune checkpoint inhibitor therapy in cancer patients Open
ICI therapy is significantly associated with an increased risk of developing hypertension. These findings support the need for routine cardiovascular monitoring in patients receiving ICI treatment.
Blue-ink tattoo reaction associated with immune checkpoint inhibitor treatment of metastatic colorectal cancer, a case report Open
Immune checkpoint inhibitors (ICIs) have revolutionized the field of oncology and transformed the management of many malignancies, especially for patients with metastatic disease. Dermatologic toxicities are among the most common immune-re…