Nolan Ung
YOU?
Author Swipe
View article: Characterization of Reduced Viscoelasticity in Sickle Cell Disease Mouse Red Blood Cells Using Parallel Plate Rheometry
Characterization of Reduced Viscoelasticity in Sickle Cell Disease Mouse Red Blood Cells Using Parallel Plate Rheometry Open
Sickle Cell Disease (SCD) is a genetic disorder characterized by the abnormal deformation of red blood cells (RBCs) into a sickle shape, leading to a cascade of complications that severely affect the circulatory system. Under normal physio…
View article: A novel thin plate spline methodology to model tissue surfaces and quantify tumor cell invasion in organ-on-chip models
A novel thin plate spline methodology to model tissue surfaces and quantify tumor cell invasion in organ-on-chip models Open
Organ-on-chip (OOC) models can be useful tools for cancer drug discovery. Advances in OOC technology have led to the development of more complex assays, yet analysis of these systems does not always account for these advancements, resultin…
View article: A-229 Immune Biomarkers Associated with COVID-19 Disease Severity in an Urban, Hospitalized Population
A-229 Immune Biomarkers Associated with COVID-19 Disease Severity in an Urban, Hospitalized Population Open
Background We sought to identify immune biomarkers associated with severe Coronavirus disease 2019 (COVID-19) in patients admitted to a large public county hospital during the early phase of the SARS-CoV-2 pandemic. We hypothesized that we…
View article: Immune biomarkers associated with COVID-19 disease severity in an urban, hospitalized population
Immune biomarkers associated with COVID-19 disease severity in an urban, hospitalized population Open
Our results confirm the known adverse association of BMI on COVID-19 severity and suggest that IP-10 and SARS-CoV-2 antibodies could be useful to identify patients most likely to experience the most severe forms of the disease.
View article: Adaptation of Imaging Mass Cytometry to Explore the Single Cell Alloimmune Landscape of Liver Transplant Rejection
Adaptation of Imaging Mass Cytometry to Explore the Single Cell Alloimmune Landscape of Liver Transplant Rejection Open
Rejection continues to be an important cause of graft loss in solid organ transplantation, but deep exploration of intragraft alloimmunity has been limited by the scarcity of clinical biopsy specimens. Emerging single cell immunoprofiling …
View article: Imaging-Based Machine Learning Analysis of Patient-Derived Tumor Organoid Drug Response
Imaging-Based Machine Learning Analysis of Patient-Derived Tumor Organoid Drug Response Open
Three-quarters of compounds that enter clinical trials fail to make it to market due to safety or efficacy concerns. This statistic strongly suggests a need for better screening methods that result in improved translatability of compounds …
View article: Creation of a Single Cell RNASeq Meta-Atlas to Define Human Liver Immune Homeostasis
Creation of a Single Cell RNASeq Meta-Atlas to Define Human Liver Immune Homeostasis Open
The liver is unique in both its ability to maintain immune homeostasis and in its potential for immune tolerance following solid organ transplantation. Single-cell RNA sequencing (scRNA seq) is a powerful approach to generate highly dimens…
View article: Paradoxical androgen receptor regulation by small molecule enantiomers
Paradoxical androgen receptor regulation by small molecule enantiomers Open
Small molecules that target the androgen receptor (AR) are the mainstay of therapy for lethal castration-resistant prostate cancer (CRPC), yet existing drugs lose their efficacy during continued treatment. This evolution of resistance is d…
View article: Paradoxical androgen receptor regulation by small molecule enantiomers
Paradoxical androgen receptor regulation by small molecule enantiomers Open
This release includes images, data, and code used in the PNAS paper "Paradoxical androgen receptor regulation by small molecule enantiomers".
View article: Paradoxical androgen receptor regulation by small molecule enantiomers
Paradoxical androgen receptor regulation by small molecule enantiomers Open
This release includes images, data, and code used in the PNAS paper "Paradoxical androgen receptor regulation by small molecule enantiomers".
View article: Creation of a single cell RNA seq meta-atlas to define human liver immune homeostasis
Creation of a single cell RNA seq meta-atlas to define human liver immune homeostasis Open
The liver is unique in both its ability to maintain immune homeostasis and in its potential for immune tolerance following solid organ transplantation. Single-cell RNA sequencing (scRNA seq) is a powerful approach to generate highly dimens…
Endosidin20 Targets the Cellulose Synthase Catalytic Domain to Inhibit Cellulose Biosynthesis Open
Plant cellulose is synthesized by rosette-structured cellulose synthase (CESA) complexes (CSCs). Each CSC is composed of multiple subunits of CESAs representing three different isoforms. Individual CESA proteins contain conserved catalytic…
Endosidin20 targets cellulose synthase catalytic domain to inhibit cellulose biosynthesis Open
Cellulose is synthesized by rosette structured cellulose synthase (CESA) complexes (CSCs), each of which is composed of multiple units of CESAs in three different isoforms. CSCs rely on vesicle trafficking for delivery to the plasma membra…
View article: mTORC2 contributes to the metabolic reprogramming in EGFR tyrosine-kinase inhibitor resistant cells in non-small cell lung cancer
mTORC2 contributes to the metabolic reprogramming in EGFR tyrosine-kinase inhibitor resistant cells in non-small cell lung cancer Open
Non-small cell lung cancer (NSCLC) patients with activating EGFR mutations are often successfully treated with EGFR tyrosine kinase inhibitor (TKI) such as erlotinib; however, treatment resistance inevitably occurs. Given tumor metabolism …
View article: Impact of Cochlear Dose on Hearing Preservation following Stereotactic Radiosurgery and Fractionated Stereotactic Radiotherapy for the Treatment of Vestibular Schwannoma
Impact of Cochlear Dose on Hearing Preservation following Stereotactic Radiosurgery and Fractionated Stereotactic Radiotherapy for the Treatment of Vestibular Schwannoma Open
Objective The objective of this study was to examine the effect of cochlear dose on hearing preservation in stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (fSRT) for vestibular schwannoma (VS). Design This is a …
View article: Regulation of Marginal Zone B-Cell Differentiation by MicroRNA-146a
Regulation of Marginal Zone B-Cell Differentiation by MicroRNA-146a Open
B-cell development in the bone marrow is followed by specification into functional subsets in the spleen, including marginal zone (MZ) B-cells. MZ B-cells are classically characterized by T-independent antigenic responses and require the e…
View article: A Systematic Analysis of the Reliability of Diffusion Tensor Imaging Tractography for Facial Nerve Imaging in Patients with Vestibular Schwannoma
A Systematic Analysis of the Reliability of Diffusion Tensor Imaging Tractography for Facial Nerve Imaging in Patients with Vestibular Schwannoma Open
Surgeons need to visualize the facial nerve reliably in relation to the vestibular schwannoma (VS) in surgical planning. Diffusion tensor imaging (DTI) tractography has enabled unprecedented in vivo preoperative visualization. We collected…